Gene - combatTB X

Rv2488c

Type: protein_coding
Name: Rv2488c
Locus Name: Rv2488c
Product: Probable transcriptional regulatory protein (LuxR-family)
Functional Category: Regulatory proteins
Location: 2797467..2800880 (- strand)
Gene Length: 3413 bp
Nucleotides: ATGGACCGGCGGCCAAGAGATTTCGAGCAATCTAGGCGCAGGTGCCGATGTAATGCGCTACGCGCTGGCTCGATGCTGGCTAGCATGAGCAAGATTCACCCCGGCGTCGACGTGGTACCTGTGGACTGGAGCGCAGATGGTGTGAGCGAGCTTGTACCGACGGGCACGGTGACGTTGCTGCTGGCCGATATCGAGGGCGCGACCCACCTGCCGGGGTCTCAGCTTGACACGACGGCGATCGCCAAACTGGACCGAACGCTGACCGAATTGGTTCGCGAGCACCGCGGGGTTTGCCCGGTCGAACAGGGCGAAGGCGACAGCTTCTTGGTGGCGTTCGCCCGCGCATCCGACGCCGTGGCGTGCGCCCTGGGCTTGCAGCGGGCGCCGCTGGCACCGATCCGGCTGCGCATCGGCATGCACACCGGGGAGGTGTCGTCACCCGACGAGGGCAACTGCGTAGGGCCGACCATCGACCGCACCGCCCGGCTGCGCGAGCTGGCCCACGGGGGCCAGACCGTGTTGTCGGGAACTACCAGCGATCTGGTTGCTGACCTGCTGCCCAAGGACGCGTGGCTGAACGACCTCGGTACCTACCGGCTGGACGACCTGCCCCGACCGGAACGGGTGGTGCAGCTGTGTCACCCTGATCTGCACAACGCGTTCCCGCCGCTGCGGACCCGGAAAGTCGTTGGTGCGCACTGTCTTCCGGCCCAGCTCACTCGGCTGGTGGGGCGCGTCGACGAAGTGGCGCAAGTCCGTGGGCTGCTGGACGTCAAACGGTGGGTCACCCTTACCGGTGTCGGCGGGGTCGGAAAGACACGCCTGGCGACACAGGTCGCGAGCGCCGTTGCCGACGGTTATCCGGACGGGGTTTGGTATGTCAACCTGGCGCCGATCACCGACCCGGCGCTGGTGCCGATCGCGGCGGCGCGGGTTTTGGGGTTGCCGGATCAGCCGGGCCGCTCGACGGTGGACACCATTGTGCGGCGTATCGGCGACCGGCGCATGCTGGTAGTGCTGGACAACTGCGAGCACTTGCTCGACGGGTGCGCGGCTCTGATCGTCGCGTTGCTCGGGGCGTGCCCAGCGCTGAGGGTATTGGCGACCAGCCGGGAACCGATCGCGGTGGCCGGTGAGCAGATTTGGCGGGTTCCCCCGCTGGGGCACGGCGAGGCGATCGAGTTGTTCACCGACCGCGCTCGTGAGGCGCGGCCCGAACTCGAGATCACTGCCGACAACCTCGCCCTGGTGACCGAGATCTGCCACCGACTCGACGGCATTCCGCTGGCGATCGAACTTGCAGCGTCGCGGGTGCGTGCCCTGGCGCTGACCGAAATCGTCGACAGCTTGCATGACCGGTTCCGCCTGCTGACCGGTGGATCGCGTATTGCGGTGCGCCGCCAGCAGACGATGCGGGCTTCCGTCGACTGGTCACATGCGCTGCTGACCGGACCGGAGCAGGTGCTGTTTCGGCGACTGGCGGTTTTCCCGAGCGGGTTTGATCTCGACGGTGCCCAAGCGGCAGCCGCCGGCGGTGACGTTCAGCGCTACGAGGTGGTCGATCTGCTCAGCCTGCTGGCAGACAAGTCTCTGGTGGTGACCGACGACAGCGACGGCCGAACGCGCTACCGCCTGCTAGAGACGGTGCGCCAGTATGCGTTGGAGAAGCTGCGTGAATCCGGCGATGCCGATGCCGTGCGTGCGCGACACCGCGACCACTACGCGGCCGTTGCCGCCGGGCTTGACGCCCCCTCGGTGGCCGGCCATGAACGCCGGCTCAACCAGGCCGAGCTCGAGATCGACAACCTACGGGCCGCTTTCGCGTTCAGCCGCGAGAATGGCGATACCGGCCACGCGTTGCTGTTGGCATCATGTCTGCAGCCGTTGTGGCGTGCCCGGGGCCGCCTGCAAGAGGGGCTGGCCTGGTTCGCCGCCGCCCTGGCCGACCACGATGCACATCCGGCGGGGGCCGACCCTGGGTTGTATGCGCGGGCACTGGCCGACCGGGCCCTGATAGATGCCGTGGCCGGCATCACCGACCGCCTAGATGATGCCCAGAAGGCGCTGGCTATAGCGCGCGACATCGAGGATCCGGCCCTGCTGGCGCGGGCGCTGACCGCGTGCGGGGGTGTCGCCGCCTACAACGCGGATCTGGCGCGACCGTGGCTGGCCGAGGCCGTCGGCCTGGCCCGGGCGGTGGGCGACAAGTGGCGGTTGGCCGAGGTTCTGGCCTGGCAGGCCTATGTCGGGTTCGCCGGCGAGGGTGACCCGGGCGCGACCCGCGCGGCGGGCGAGGAGGCACGAAGCCTCGCCGACGAGATTGGTGATGCATTCCTTTCACGTTCATGTCGCTGGGCGCTGGCCGCGGCGAATCTCTGGCAGGGCAACCTCGAGGCAGCGGTCGGCCTGTCGCGCGAGGTGATCGGCGAGTCCGACGCCGCGCACGACATGGTTAGCAGCTGCGCGGGCCAGGCTTGCTTGGCGCACGCGTTAGCGCACCGCGGCGACACCGAGGCGGCCGCCGCCGCCCAAGCCAGCATCGACACCGCCGTTGGACTCAGCCCGGTGCTGTCGGGCTCGGCCTGCTCCGCGCTGGTCTTCGCGACCCTGGCCGCCGGTGACGTCGCGGCCGCCGAACACGCCCGCGAATCGGCAACGCGATTCTTTGGTGCCAGCGCGGCGGCGATCATCAACGACCCCACCAGTTCGGCTCAAATATCGTGTGCGCGAGGTGATCTGAACGCGGCGCACCGATTGGCCGACGGCGCAGCGTCGATCACTCGTGGCGTGCACCGCGCCCGCGCCCTGACTACCCGTTGCCGCATCGAGATCGCCCAAGGGGATCGCCACCGGGCCGAGCGCGATGCCCACGACGCCCTCGGCGTGGCCGCGTCCATTGGGGCATACCTATGGGTCCCCGACATTCTCGAGTGCCTCGCCTCGGTGATGGCGGATGCCGGCAGCAACCGGGAAGCGGTGCGGCTGTTCGGCGCGGCCGACGCGGCCCGGGGGCGCATGGGAGCGGTCCGCTTCGGGATCTACCAGGCGGGCTGTAACTCGTCGCTAGCCACCCTTCGAAAATCCATGGGTGACAGCGAGTTCGACGATGCCTGGGCCGAAGGAACTGCGTTATCGATCGATGAGGCGATCGCGTACGCGCAACGAGGCCGCGGTGCACGGAAACGCCCGACAAGTGGCTGGGGCGCGTTGACACCGACAGAGCTTGAGGTGGCTCTACTGGTCGGTGAGGGACTCAGCAACAAGGAGATCGGCGTCCGCCTATTCATCTCGCCGCGGACCGTGCATTCCCACTTGACCCACGTCTACACCAAGCTCGGCCTGTCCTCCCGTCTTCAACTCGCGCAGCAAGCTGCGCGCCGGGGCGAATCAGAACGAGGGCCGTCGCGGCCATA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

cyclic nucleotide biosynthetic process GO:0009190 biological_process
cell wall GO:0005618 cellular_component
cytosol GO:0005829 cellular_component
DNA binding GO:0003677 molecular_function
regulation of transcription, DNA-templated GO:0006355 biological_process
plasma membrane GO:0005886 cellular_component
intracellular signal transduction GO:0035556 biological_process
phosphorus-oxygen lyase activity GO:0016849 molecular_function
ADP binding GO:0043531 molecular_function

InterPro

UniProt: O53213
GenBank: Rv2488c
EnsemblBacteria: Rv2488c
Mycobrowser: Rv2488c

Summary

Name: Probable transcriptional regulatory protein (LuxR-family)
Family: Unknown
Protein Sequence: MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSELVPTGTVTLLLADIEGATHLPGSQLDTTAIAKLDRTLTELVREHRGVCPVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSSPDEGNCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLNDLGTYRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLVGRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWYVNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNCEHLLDGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHGEAIELFTDRAREARPELEITADNLALVTEICHRLDGIPLAIELAASRVRALALTEIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPEQVLFRRLAVFPSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDDSDGRTRYRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPSVAGHERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARGRLQEGLAWFAAALADHDAHPAGADPGLYARALADRALIDAVAGITDRLDDAQKALAIARDIEDPALLARALTACGGVAAYNADLARPWLAEAVGLARAVGDKWRLAEVLAWQAYVGFAGEGDPGATRAAGEEARSLADEIGDAFLSRSCRWALAAANLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHRGDTEAAAAAQASIDTAVGLSPVLSGSACSALVFATLAAGDVAAAEHARESATRFFGASAAAIINDPTSSAQISCARGDLNAAHRLADGAASITRGVHRARALTTRCRIEIAQGDRHRAERDAHDALGVAASIGAYLWVPDILECLASVMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMGDSEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTSGWGALTPTELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQLAQQAARRGESERGPSRP
Mass: 120,818 Da
Length: 1137 Aa

Rv2488c doesn't seem to be a targeted by any drug.

Rv2488c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.