bkdB
- Type
- protein_coding
- Name
- bkdB
- Locus Name
-
Rv2496c
- Product
-
Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 2809936..2810982 (- strand)
- Gene Length
- 1046 bp
- Nucleotides
-
ATGACTCAAATCGCAGACCGTCCGGCCAGGCCGGATGAGACGCTTGCGGTAGCGGTGAGCGACATCACGCAGTCGTTGACCATGGTCCAGGCGATCAACCGCGCCCTGTACGACGCGATGGCCGCCGACGAGCGGGTATTGGTGTTTGGCGAGGATGTCGCGGTCGAGGGTGGGGTGTTTCGGGTGACCGAGGGACTGGCCGATACGTTCGGTGCAGACCGGTGCTTCGACACGCCACTGGCGGAGTCCGCGATCATCGGAATAGCCGTCGGGTTGGCACTACGTGGCTTTGTGCCGGTGCCAGAAATCCAGTTCGACGGCTTTTCCTATCCGGCTTTCGACCAAGTGGTGAGCCATCTGGCCAAGTACCGGACTCGCACCCGCGGTGAGGTGGACATGCCGGTGACCGTCCGGATCCCCTCGTTTGGCGGTATCGGTGCGGCCGAACATCATTCGGACTCCACGGAGTCCTACTGGGTGCACACCGCGGGCCTCAAGGTGGTGGTGCCGTCGACACCCGGTGACGCTTACTGGCTGCTGCGGCACGCTATCGCCTGCCCGGACCCCGTGATGTATCTGGAGCCCAAACGCCGCTACCACGGCCGCGGGATGGTCGACACTAGCCGGCCGGAACCGCCGATCGGGCACGCGATGGTGCGCCGGTCCGGCACCGATGTGACCGTGGTAACGTACGGAAACCTGGTGAGCACCGCCCTGTCTAGCGCGGATACTGCAGAGCAGCAACATGATTGGAGTCTGGAGGTTATCGATCTGCGGTCGTTGGCGCCGCTGGACTTCGACACCATTGCTGCGTCGATCCAGCGCACCGGGCGTTGCGTGGTGATGCACGAAGGGCCGCGCAGCCTCGGCTATGGTGCCGGTCTGGCCGCGCGCATCCAGGAAGAGATGTTCTACCAATTGGAGGCTCCGGTGTTGCGTGCCTGCGGTTTTGACACACCCTACCCGCCTGCGCGGTTGGAAAAATTGTGGTTACCCGGCCCCGACCGGCTGTTGGACTGCGTCGAACGTGTGCTGCGTCAGCCATG
- Drug Resistance
- Mutations
- Function
- Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2). {ECO:0000269|PubMed:21238944}.
- Family
-
Unknown
- GO
-
- response to nutrient GO:0007584 biological_process
- branched-chain amino acid catabolic process GO:0009083 biological_process
- 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity GO:0003863 molecular_function
- alpha-ketoacid dehydrogenase activity GO:0003826 molecular_function
- cell wall GO:0005618 cellular_component
- plasma membrane GO:0005886 cellular_component
- InterPro
Summary
- Name
- 3-methyl-2-oxobutanoate dehydrogenase subunit beta (EC 1.2.4.4) (Branched-chain alpha-ketoacid dehydrogenase E1 component subunit beta) (BCKADH E1-beta)
- Family
- Unknown
- Protein Sequence
-
MTQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHGRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTPYPPARLEKLWLPGPDRLLDCVERVLRQP
- Mass
- 38,064 Da
- Length
- 348 Aa
Rv2496c doesn't seem to be a targeted by any drug.
-
-
Pyruvate metabolism mtu00620
mtu00620PATHWAY_MAP mtu00620 Pyruvate metabolism
-
-
-
Citrate cycle (TCA cycle) mtu00020
mtu00020Metabolism; Carbohydrate metabolism
-
-
-
Glycolysis / Gluconeogenesis mtu00010
mtu00010Metabolism; Carbohydrate metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
- Cell Host Microbe. 2011 Jan 20;9(1):21-31. doi: 10.1016/j.chom.2010.12.004.
- Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
- Mol Microbiol. 2005 Aug;57(3):859-68. doi: 10.1111/j.1365-2958.2005.04741.x.
- Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling.
- Mol Microbiol. 2002 Feb;43(3):717-31.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.