Gene - combatTB X

accA1

Type: protein_coding
Name: accA1
Locus Name: Rv2501c
Product: Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA1: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
Functional Category: Lipid metabolism
Location: 2814916..2816880 (- strand)
Gene Length: 1964 bp
Nucleotides: ATGTTTGACACCGTACTAGTGGCCAACCGCGGTGAGATCGCGGTTCGGGTGATTCGGACGCTGCGCCGGCTAGGCATCCGGTCGGTCGCGGTCTACAGCGACCCCGACGTCGATGCCCGCCACGTCTTGGAGGCGGACGCTGCGGTGCGGCTGGGGCCCGCCCCAGCACGCGAAAGCTACCTCGATATCGGCAAGGTGCTCGATGCTGCGGCGCGCACCGGAGCCCAGGCGATCCATCCGGGCTACGGGTTTCTTGCCGAGAATGCCGATTTCGCTGCGGCGTGTGAACGCGCCCGGGTGGTGTTCCTGGGTCCGCCGGCGCGCGCGATCGAGGTGATGGGCGACAAGATCGCCGCCAAGAACGCGGTCGCCGCTTTCGATGTTCCGGTGGTGCCCGGTGTGGCGCGCGCCGGGCTGACGGACGACGCGCTGGTCACCGCTGCCGCTGAGGTGGGCTATCCGGTGCTGATCAAACCGTCGGCCGGCGGCGGCGGCAAAGGGATGCGGTTAGTGCAAGATCCGGCGCGGCTGCCTGAGGCGCTGGTGAGTGCCCGGCGCGAAGCCATGTCTTCGTTCGGGGACGATACGCTATTCCTGGAGCGGTTTGTGTTGCGGCCCAGGCACATCGAAGTGCAGGTGCTTGCCGACGCTCACGGCAACGTGGTGCATCTGGGTGAGCGTGAGTGCAGCCTCCAGCGGCGCCACCAGAAGGTTATCGAGGAGGCGCCGTCGCCACTGCTTGACCCGCAGACCCGCGAGCGCATCGGGGTCGCGGCCTGCAACACCGCCCGCTGCGTGGACTACGTCGGCGCCGGCACGGTGGAGTTCATCGTCTCCGCGCAGCGCCCCGACGAGTTCTTTTTCATGGAGATGAATACCCGGCTGCAGGTGGAACACCCGGTCACCGAGGCGATTACTGGATTGGACCTGGTCGAGTGGCAGTTGCGGGTGGGTGCGGGCGAAAAGTTGGGCTTCGCCCAAAACGACATCGAGCTGCGTGGGCACGCGATCGAGGCTCGGGTGTATGCGGAGGATCCCGCGCGGGAATTCCTGCCCACCGGCGGCCGGGTGCTGGCGGTGTTCGAACCCGCCGGCCCCGGGGTGCGGGTGGATTCGTCACTGCTAGGCGGCACGGTGGTCGGCAGTGATTACGACCCGTTGCTCACCAAGGTGATTGCGCACGGGGCCGATCGCGAGGAAGCGCTGGATCGGCTGGACCAGGCGCTGGCGCGGACTGCGGTGCTGGGAGTGCAGACCAATGTCGAGTTCCTTCGCTTTCTGCTCGCCGACGAGCGGGTGCGGGTCGGGGATTTGGACACCGCTGTACTGGACGAGCGATCGGCCGATTTCACTGCGCGGCCGGCGCCTGACGACGTGCTAGCTGCCGGCGGCCTCTACCGCCAGTGGGCCCTGGCCCGGCGCGCACAGGGCGACCTGTGGGCCGCGCCGTCCGGATGGCGCGGCGGGGGCCATATGGCACCGGTCCGCACCGCCATGCGCACCCCGCTGCGCAGCGAGACCGTTTCGGTGTGGGGGCCACCCGAGTCGGCGCAGGTTCAGGTTGGCGATGGTGAGATCGATTGTGCGAGCGTGCAGGTCACCCGAGAACAGATGAGCGTGACGATAAGCGGGCTGCGCCGGGATTATCGGTGGGCAGAGGCTGACCGGCACCTGTGGATCGCCGACGAGCGCGGGACTTGGCACCTGCGCGAGGCCGAGGAGCACAAGATTCACCGCGCCGTGGGTGCGCGGCCGGCGGAGGTCGTCAGCCCTATGCCTGGCAGCGTGATCGCCGTGCAGGTCGAGTCCGGCTCCCAGATCTCTGCGGGTGATGTGGTGGTGGTGGTGGAAGCGATGAAGATGGAGCACTCGCTGGAGGCGCCGGTTTCGGGACGGGTACAGGTGTTGGTGTCCGTTGGCGATCAGGTGAAAGTCGAACAGGTACTGGCGAGGATCAAGGACTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. {ECO:0000250}.

Family

Unknown

GO

metal ion binding GO:0046872 molecular_function
ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component
biotin carboxylase activity GO:0004075 molecular_function
fatty acid biosynthetic process GO:0006633 biological_process

InterPro

UniProt: P9WPQ3
GenBank: Rv2501c
EnsemblBacteria: Rv2501c
Mycobrowser: Rv2501c

Summary

Name: Acetyl-/propionyl-coenzyme A carboxylase alpha chain [Includes: Biotin carboxylase (EC 6.3.4.14); Biotin carboxyl carrier protein (BCCP)]
Family: Unknown
Protein Sequence: MFDTVLVANRGEIAVRVIRTLRRLGIRSVAVYSDPDVDARHVLEADAAVRLGPAPARESYLDIGKVLDAAARTGAQAIHPGYGFLAENADFAAACERARVVFLGPPARAIEVMGDKIAAKNAVAAFDVPVVPGVARAGLTDDALVTAAAEVGYPVLIKPSAGGGGKGMRLVQDPARLPEALVSARREAMSSFGDDTLFLERFVLRPRHIEVQVLADAHGNVVHLGERECSLQRRHQKVIEEAPSPLLDPQTRERIGVAACNTARCVDYVGAGTVEFIVSAQRPDEFFFMEMNTRLQVEHPVTEAITGLDLVEWQLRVGAGEKLGFAQNDIELRGHAIEARVYAEDPAREFLPTGGRVLAVFEPAGPGVRVDSSLLGGTVVGSDYDPLLTKVIAHGADREEALDRLDQALARTAVLGVQTNVEFLRFLLADERVRVGDLDTAVLDERSADFTARPAPDDVLAAGGLYRQWALARRAQGDLWAAPSGWRGGGHMAPVRTAMRTPLRSETVSVWGPPESAQVQVGDGEIDCASVQVTREQMSVTISGLRRDYRWAEADRHLWIADERGTWHLREAEEHKIHRAVGARPAEVVSPMPGSVIAVQVESGSQISAGDVVVVVEAMKMEHSLEAPVSGRVQVLVSVGDQVKVEQVLARIKD
Mass: 70,592 Da
Length: 654 Aa

Rv2501c doesn't seem to be a targeted by any drug.

Propanoate metabolism mtu00640
mtu00640
PATHWAY_MAP mtu00640 Propanoate metabolism

Glyoxylate and dicarboxylate metabolism mtu00630
mtu00630
PATHWAY_MAP mtu00630 Glyoxylate and dicarboxylate metabolism

Pyruvate metabolism mtu00620
mtu00620
PATHWAY_MAP mtu00620 Pyruvate metabolism

Valine, leucine and isoleucine degradation mtu00280
mtu00280
PATHWAY_MAP mtu00280 Valine, leucine and isoleucine degradation

Fatty acid biosynthesis mtu00061
mtu00061
PATHWAY_MAP mtu00061 Fatty acid biosynthesis

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .: PLoS One. 2010 Jan 6;5(1):e8589. doi: 10.1371/journal.pone.0008589.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
Lipid synthesis in mycobacteria: characterization of the biotin carboxyl carrier protein genes from Mycobacterium leprae and M. tuberculosis.: J Bacteriol. 1994 May;176(9):2525-31. doi: 10.1128/jb.176.9.2525-2531.1994.