Gene - combatTB X

efp

Type: protein_coding
Name: efp
Locus Name: Rv2534c
Product: Probable elongation factor P Efp
Functional Category: Information pathways
Location: 2858727..2859290 (- strand)
Gene Length: 563 bp
Nucleotides: GTGGCGACCACTGCTGACTTCAAGAACGGGCTGGTCCTGGTAATCGACGGCCAGCTGTGGACAATCACCGAGTTCCAGCACGTCAAACCGGGCAAGGGTCCGGCGTTCGTGCGCACCAAGTTGAAGAACGTGCTCTCGGGCAAGGTCGTCGACAAGACGTTCAACGCCGGGGTGAAGGTGGACACCGCCACCGTCGACCGGCGCGATACCACCTACCTTTACCGCGACGGCTCGGACTTCGTGTTCATGGACAGCCAAGACTACGAGCAGCACCCGCTGCCGGAGGCCCTGGTCGGGGACGCGGCACGGTTCCTGCTGGAGGGCATGCCGGTGCAGGTGGCGTTCCACAACGGCGTGCCGCTATACATCGAGCTGCCGGTGACCGTCGAGCTCGAGGTCACTCACACCGAGCCCGGCTTGCAGGGCGACCGGTCCAGCGCGGGCACCAAGCCGGCCACCCTTCAGACCGGAGCCCAGATCAACGTGCCGCTGTTCATCAATACCGGAGACAAACTAAAGGTGGATTCGCGCGACGGTAGCTACCTGGGCCGGGTCAACGCCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity). {ECO:0000250}.

Family

Elongation factor P family

GO

cytoplasm GO:0005737 cellular_component
translation elongation factor activity GO:0003746 molecular_function

InterPro

UniProt: P9WNM3
GenBank: Rv2534c
EnsemblBacteria: Rv2534c
Mycobrowser: Rv2534c

Summary

Name: Elongation factor P (EF-P)
Family: Elongation factor P family
Protein Sequence: MATTADFKNGLVLVIDGQLWTITEFQHVKPGKGPAFVRTKLKNVLSGKVVDKTFNAGVKVDTATVDRRDTTYLYRDGSDFVFMDSQDYEQHPLPEALVGDAARFLLEGMPVQVAFHNGVPLYIELPVTVELEVTHTEPGLQGDRSSAGTKPATLQTGAQINVPLFINTGDKLKVDSRDGSYLGRVNA
Mass: 20,407 Da
Length: 187 Aa

Rv2534c doesn't seem to be a targeted by any drug.

Rv2534c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.