Gene - combatTB X

Rv2559c

Type: protein_coding
Name: Rv2559c
Locus Name: Rv2559c
Product: Conserved hypothetical alanine leucine valine rich protein
Functional Category: Conserved hypotheticals
Location: 2878571..2879929 (- strand)
Gene Length: 1358 bp
Nucleotides: ATGCCTGAAGCCGTGTCCGACGGTCTGTTTGACGTGCCCGGCGTACCGATGACGTCCGGCCATGACCTGGGCGCTTCGGCCGGGGCACCGCTGGCGGTGCGGATGCGTCCGGCGTCGCTGGACGAAGTGGTCGGCCAGGACCACTTGCTGGCGCCCGGTTCGCCGTTGCGCCGGCTGGTCGAGGGCTCGGGGGTGGCGTCGGTGATCCTCTACGGTCCCCCGGGCAGCGGCAAGACAACGCTGGCGGCGTTGATCTCGCAGGCCACCGGCCGCCGGTTCGAGGCCCTGTCGGCATTGTCGGCCGGCGTCAAGGAAGTGCGGGCGGTCATCGAGAATTCGCGAAAAGCGCTGCTTCACGGCGAGCAGACCGTGCTGTTCATCGACGAGGTGCACCGATTTTCCAAGACCCAACAAGACGCCCTGCTGTCGGCGGTGGAACACCGGGTGGTGCTGTTGGTGGCGGCGACCACCGAGAACCCGTCGTTTTCGGTGGTGGCACCGCTGCTGTCGCGGTCGCTGATCCTGCAGCTGCGGCCGCTGACGGCCGAGGACACCCGCGCGGTAGTACAACGCGCGATCGATGACCCCCGCGGCCTGGGCAGGGCAGTCGCGGTAGCGCCTGAGGCCGTCGACCTGCTGGTGCAACTCGCGGCCGGCGACGCCCGGCGCGCCCTGACCGCGCTGGAAGTAGCGGCCGAGGCAGCCCAGGCGGCCGGCGAGCTGGTCAGCGTGCAAACCATCGAGCGGTCGGTGGACAAAGCCGCGGTGCGCTACGACCGTGACGGCGACCAGCACTACGACGTCGTCAGCGCCTTCATCAAATCGGTGCGCGGTTCCGACGTCGATGCCGCGCTGCACTATTTGGCCCGCATGCTGGTCGCCGGGGAGGACCCGCGGTTCATCGCCCGCCGGCTGATGATTCTGGCCAGCGAGGACATCGGCATGGCCGGCCCGAGCGCGCTGCAGGTGGCGGTCGCCGCCGCACAGACGGTGGCGCTGATCGGCATGCCCGAAGCCCAGCTGACGCTGGCGCACGCCACCATCCACCTGGCCACCGCACCGAAGTCAAACGCCGTCACCACGGCGTTGGCCGCGGCGATGAACGACATCAAGGCCGGCAAGGCCGGTCTGGTGCCGGCTCATCTGCGTGACGGGCATTACTCCGGGGCGGCGGCGCTGGGCAATGCACAGGGCTACAAATATTCCCATGACGACCCGGATGGCGTTGTGGCCCAGCAATACCCGCCCGACGAGTTGGTGGACGTGGACTACTACCGGCCCACTGGTCGCGGCGGCGAACGCGAGATCGCCGGCCGCCTGGACCGCCTGCGGGCAATCATCCGCAAGAAACGGGGGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

AAA ATPase family, RarA/MGS1/WRNIP1 subfamily

GO

single-stranded DNA helicase activity GO:0017116 molecular_function
ATP binding GO:0005524 molecular_function
DNA binding GO:0003677 molecular_function
DNA-dependent DNA replication GO:0006261 biological_process
regulation of DNA repair GO:0006282 biological_process
enzyme activator activity GO:0008047 molecular_function

InterPro

UniProt: P9WQN1
GenBank: Rv2559c
EnsemblBacteria: Rv2559c
Mycobrowser: Rv2559c

Summary

Name: Uncharacterized AAA domain-containing protein Rv2559c
Family: AAA ATPase family, RarA/MGS1/WRNIP1 subfamily
Protein Sequence: MPEAVSDGLFDVPGVPMTSGHDLGASAGAPLAVRMRPASLDEVVGQDHLLAPGSPLRRLVEGSGVASVILYGPPGSGKTTLAALISQATGRRFEALSALSAGVKEVRAVIENSRKALLHGEQTVLFIDEVHRFSKTQQDALLSAVEHRVVLLVAATTENPSFSVVAPLLSRSLILQLRPLTAEDTRAVVQRAIDDPRGLGRAVAVAPEAVDLLVQLAAGDARRALTALEVAAEAAQAAGELVSVQTIERSVDKAAVRYDRDGDQHYDVVSAFIKSVRGSDVDAALHYLARMLVAGEDPRFIARRLMILASEDIGMAGPSALQVAVAAAQTVALIGMPEAQLTLAHATIHLATAPKSNAVTTALAAAMNDIKAGKAGLVPAHLRDGHYSGAAALGNAQGYKYSHDDPDGVVAQQYPPDELVDVDYYRPTGRGGEREIAGRLDRLRAIIRKKRG
Mass: 47,499 Da
Length: 452 Aa

Rv2559c doesn't seem to be a targeted by any drug.

Rv2559c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.