ppiB
- Type
- protein_coding
- Name
- ppiB
- Locus Name
-
Rv2582
- Product
-
Probable peptidyl-prolyl cis-trans isomerase B PpiB (cyclophilin) (PPIase) (rotamase) (peptidylprolyl isomerase)
- Functional Category
-
Information pathways
- Location
- 2906814..2907740 (+ strand)
- Gene Length
- 926 bp
- Nucleotides
-
TGGGCCACTTGACACCGGTCGCGGCGCCCCGATTAGCCTGTGCTTTCGTGCCGACCAATGCTCAGCGACGTGCCACAGCCAAACGCAAACTCGAACGACAACTAGAGCGCCGCGCCAAGCAAGCCAAACGCCGTCGCATCTTGACTATCGTCGGTGGCTCACTCGCAGCGGTGGCCGTGATCGTCGCGGTAGTCGTCACGGTGGTGGTCAACAAGGACGACCACCAGAGCACCACGTCAGCAACCCCCACCGACTCGGCCTCGACCAGCCCCCCGCAGGCCGCGACCGCTCCCCCGCTGCCGCCGTTCAAGCCGTCGGCCAACCTCGGCGCCAACTGCCAGTACCCGCCGTCGCCGGACAAGGCCGTCAAACCGGTCAAGTTGCCCCGGACCGGCAAGGTACCCACCGACCCGGCCCAGGTCAGCGTGAGCATGGTGACCAACCAGGGCAACATCGGTCTAATGCTGGCCAACAACGAATCGCCGTGTACGGTCAATAGTTTCGTCAGCCTCGCGCAGCAGGGTTTCTTCAAGGGCACCACTTGTCACCGGCTGACCACCTCACCAATGTTGGCGGTTCTGCAATGCGGCGACCCTAAGGGCGACGGCACGGGCGGTCCGGGCTACCAGTTCGCCAACGAATACCCCACCGACCAATACTCGGCGAACGACCCCAAGTTGAACGAGCCCGTCATCTATCCGCGCGGGACACTGGCCATGGCCAACGCCGGCCCTAATACCAACAGCAGCCAGTTCTTCATGGTCTACCGGGACTCAAAGCTGCCACCCCAATACACCGTGTTCGGCACGATCCAGGCCGACGGACTGACCACCCTGGACAAGATCGCCAAGGCCGGCGTCGCCGGTGGCGGCGAAGACGGCAAGCCCGCCACCGAAGTCACCATCACGTCGGTGCTGCTGGATTAG
- Drug Resistance
- Mutations
- Function
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.
- Family
-
Cyclophilin-type PPIase family
- GO
-
- peptidyl-prolyl cis-trans isomerase activity GO:0003755 molecular_function
- integral component of plasma membrane GO:0005887 cellular_component
- plasma membrane GO:0005886 cellular_component
- InterPro
Summary
- Name
- Probable peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Rotamase B)
- Family
- Cyclophilin-type PPIase family
- Protein Sequence
-
MGHLTPVAAPRLACAFVPTNAQRRATAKRKLERQLERRAKQAKRRRILTIVGGSLAAVAVIVAVVVTVVVNKDDHQSTTSATPTDSASTSPPQAATAPPLPPFKPSANLGANCQYPPSPDKAVKPVKLPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNESPCTVNSFVSLAQQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSANDPKLNEPVIYPRGTLAMANAGPNTNSSQFFMVYRDSKLPPQYTVFGTIQADGLTTLDKIAKAGVAGGGEDGKPATEVTITSVLLD
- Mass
- 32,371 Da
- Length
- 308 Aa
Rv2582 doesn't seem to be a targeted by any drug.
Rv2582 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.