secF
- Type
- protein_coding
- Name
- secF
- Locus Name
-
Rv2586c
- Product
-
Probable protein-export membrane protein SecF
- Functional Category
-
Cell wall and cell processes
- Location
- 2912683..2914011 (- strand)
- Gene Length
- 1328 bp
- Nucleotides
-
ATGGCGTCGAAAGCAAAGACCGGCCGCGACGACGAAGCCACGTCGGCGGTCGAACTCACCGAGGCCACCGAGAGTGCTGTGGCGCGGACCGACGGCGACAGCACCACAGACACCGCCTCGAAGCTGGGGCACCATAGCTTCCTTTCGCGCCTGTACACCGGCACCGGGGCGTTTGAGGTAGTGGGACGCCGCCGGTTGTGGTTTGGCGTGAGCGGTGCGATCGTCGCGGTGGCCATCGCCAGCATCGTCTTTCGTGGGTTCACCTTCGGCATCGATTTCAAAGGCGGTACCACGGTGTCGTTCCCGCGTGGCAGCACCCAAGTCGCGCAGGTCGAAGACGTCTACTACCGGGCCCTCGGCAGTGAGCCCCAGTCGGTGGTGATCGTCGGGGCCGGTGCTTCGGCGACGGTGCAGATTCGTTCGGAGACGCTGACCAGCGACCAGACGGCCAAGCTGCGGGACGCCCTATTCGAGGCCTTCGGGCCCAAGGGAACCGACGGTCAGCCCAGCAAGCAGGCCATCAGCGACTCGGCGGTGTCGGAGACCTGGGGCGGTCAGATCACCAAGAAGGCGGTGATCGCGCTGGTGGTGTTTCTGGTGCTGGTCGCCCTCTACATTACCGTGCGCTACGAGCGCTACATGACCATCTCGGCGATAACGGCCATGCTCTTCGACCTGACCGTCACCGCCGGCGTGTATTCCCTGGTGGGTTTCGAAGTCACCCCGGCCACGGTCATCGGCCTGCTGACCATTCTCGGGTTCTCGCTCTATGACACCGTCATCGTGTTCGACAAGGTCGAGGAGAACACCCATGGCTTCCAGCACACCACCCGGCGCACCTTCGCCGAGCAGGCCAACCTGGCGATCAACCAGACGTTCATGCGGTCGATCAACACCAGCCTGATCGGCGTGTTGCCGGTGTTGGCGCTGATGGTGGTGGCGGTCTGGCTGCTGGGCGTCGGCACTCTCAAAGACCTGGCGCTGGTGCAGCTGATCGGCATCATCATCGGCACCTACTCGTCAATCTTCTTCGCCACGCCGCTGTTGGTTACCCTCCGTGAGCGCACGGAGTTGGTGCGCAACCACACCCGTCGGGTGCTCAAACGGCGTAACTCCGGCTCGCCGGCGGGATCAGAGGACGCCAGCACGGATGGCGGCGAGCAGCCGGCAGCCGCTGATGAACAGTCGCTGGTGGGGATCACGCAGGCCAGCAGCCAATCCGCCCCGCGGGCGGCCCAGGGCTCCAGCAAGCCGGCGCCGGGGGCGCGCCCAGTGCGTCCCGTCGGTACCAGGCGTCCGACCGGCAAGCGGAACGCCGGTCGGCGGTA
- Drug Resistance
- Mutations
- Function
- Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. {ECO:0000255|HAMAP-Rule:MF_01464}.
- Family
-
SecD/SecF family, SecF subfamily
- GO
-
- P-P-bond-hydrolysis-driven protein transmembrane transporter activity GO:0015450 molecular_function
- protein transport GO:0015031 biological_process
- cell wall GO:0005618 cellular_component
- integral component of plasma membrane GO:0005887 cellular_component
- plasma membrane GO:0005886 cellular_component
- evasion or tolerance by symbiont of host-produced reactive oxygen species GO:0052059 biological_process
- intracellular protein transmembrane transport GO:0065002 biological_process
- protein transport by the Sec complex GO:0043952 biological_process
- protein targeting GO:0006605 biological_process
- InterPro
Summary
- Name
- Protein translocase subunit SecF
- Family
- SecD/SecF family, SecF subfamily
- Protein Sequence
-
MASKAKTGRDDEATSAVELTEATESAVARTDGDSTTDTASKLGHHSFLSRLYTGTGAFEVVGRRRLWFGVSGAIVAVAIASIVFRGFTFGIDFKGGTTVSFPRGSTQVAQVEDVYYRALGSEPQSVVIVGAGASATVQIRSETLTSDQTAKLRDALFEAFGPKGTDGQPSKQAISDSAVSETWGGQITKKAVIALVVFLVLVALYITVRYERYMTISAITAMLFDLTVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRSINTSLIGVLPVLALMVVAVWLLGVGTLKDLALVQLIGIIIGTYSSIFFATPLLVTLRERTELVRNHTRRVLKRRNSGSPAGSEDASTDGGEQPAAADEQSLVGITQASSQSAPRAAQGSSKPAPGARPVRPVGTRRPTGKRNAGRR
- Mass
- 47,014 Da
- Length
- 442 Aa
Rv2586c doesn't seem to be a targeted by any drug.
-
-
Tolerance of reactive oxygen produced by macrophages R-HSA-1222387
Homo sapiensR-HSA-1222387
-
-
-
Bacterial secretion system mtu03070
mtu03070Environmental Information Processing; Membrane transport
-
-
-
Protein export mtu03060
mtu03060Genetic Information Processing; Folding, sorting and degradation
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.