Gene - combatTB X

secD

Type: protein_coding
Name: secD
Locus Name: Rv2587c
Product: Probable protein-export membrane protein SecD
Functional Category: Cell wall and cell processes
Location: 2914015..2915736 (- strand)
Gene Length: 1721 bp
Nucleotides: GTGGCATCGTCTTCGGCGCCGGTGCACCCTGCCCGTTACCTGTCGGTGTTCCTGGTGATGCTGATCGGCATCTATTTGCTGGTGTTTTTCACCGGGGACAAGCACACCGCCCCCAAACTCGGCATTGACCTGCAGGGCGGCACCAGGGTCACGCTGACCGCGCGCACACCGGACGGCTCGGCCCCGAGCCGGGAAGCGCTGGCACAGGCGCAGCAAATCATCAGCGCGCGGGTCAACGGGCTGGGAGTGTCCGGGTCGGAGGTGGTCGTCGACGGTGACAACCTGGTCATCACGGTGCCCGGCAACGACGGCAGCGAGGCACGCAACCTCGGACAGACCGCTCGGCTGTACATCCGGCCGGTGCTCAACTCGATGCCGGCGCAGCCCGCAGCCGAAGAACCGCAGCCGGCACCCAGCGCCGAACCGCAGCCGCCCGGTCAACCCGCCGCACCGCCGCCAGCCCAATCGGGGGCGCCGGCTTCACCGCAACCTGGGGCCCAACCGCGGCCCTATCCGCAGGACCCGGCGCCATCGCCCAACCCGACCTCACCGGCCAGCCCGCCGCCGGCGCCGCCCGCTGAGGCGCCGGCCACGGATCCGCGCAAGGATCTCGCCGAGCGCATCGCCCAGGAGAAGAAGCTGCGGCAGAGCACCAACCAATACATGCAGATGGTTGCACTGCAATTCCAGGCGACCCGCTGCGAGAGCGACGACATTTTGGCCGGCAACGACGACCCGAAACTGCCGTTGGTGACCTGCTCGACCGACCACAAGACCGCGTACCTGCTGGCGCCGTCGATCATCAGCGGCGACCAGATCCAAAACGCCACCTCGGGTATGGACCAGCGCGGCATCGGCTACGTCGTCGACCTGCAGTTCAAGGGTCCGGCGGCCAACATCTGGGCCGACTACACCGCCGCCCATATCGGCACCCAGACGGCGTTCACCCTGGACTCGCAGGTTGTCAGTGCACCGCAGATCCAGGAAGCGATCCCCGGCGGCCGAACCCAGATCAGCGGTGGGGATCCGCCATTCACCGCGGCGACCGCACGCCAGCTCGCCAACGTCCTCAAGTACGGGTCGCTGCCGCTGTCCTTCGAACCGTCGGAAGCCCAAACGGTTTCGGCGACCTTGGGGTTGTCATCGCTGCGCGCGGGCATGATCGCGGGTGCGATCGGCCTGCTGTTGGTGCTGGTGTATTCGCTGCTCTACTACCGAGTGCTGGGACTGCTCACGGCCTTGTCGCTAGTGGCTTCTGGCTCAATGGTTTTTGCGATCCTGGTGCTCTTGGGCCGATATATCAACTACACCCTAGATCTGGCTGGTATTGCGGGCCTGATCATCGGTATCGGGACCACCGCCGACTCGTTCGTGGTGTTCTTCGAACGCATCAAAGACGAGATCCGCGAAGGCCGTTCGTTCCGGTCGGCAGTGCCGCGCGGTTGGGCGCGTGCCCGCAAGACGATCGTGTCGGGCAACGCCGTCACTTTCCTGGCCGCTGCCGTGCTGTACTTTCTGGCGATCGGTCAGGTGAAGGGGTTCGCGTTCACCCTGGGCCTCACCACGATCCTGGACCTCGTCGTGGTGTTCTTGGTGACGTGGCCGTTGGTGTATCTGGCGTCCAAATCGTCGCTGCTGGCCAAGCCGGCATACAACGGCCTGGGAGCGGTGCAGCAGGTCGCACGCGAACGCCGGGCCATGGCTCGGACGGGACGGGGATA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. {ECO:0000255|HAMAP-Rule:MF_01463}.

Family

SecD/SecF family, SecD subfamily

GO

protein targeting GO:0006605 biological_process
protein transport by the Sec complex GO:0043952 biological_process
intracellular protein transmembrane transport GO:0065002 biological_process
evasion or tolerance by symbiont of host-produced reactive oxygen species GO:0052059 biological_process
plasma membrane GO:0005886 cellular_component
integral component of plasma membrane GO:0005887 cellular_component
cytosol GO:0005829 cellular_component
extracellular region GO:0005576 cellular_component
cell wall GO:0005618 cellular_component
protein transport GO:0015031 biological_process
P-P-bond-hydrolysis-driven protein transmembrane transporter activity GO:0015450 molecular_function

InterPro

UniProt: P9WGP1
GenBank: Rv2587c
EnsemblBacteria: Rv2587c
Mycobrowser: Rv2587c

Summary

Name: Protein translocase subunit SecD
Family: SecD/SecF family, SecD subfamily
Protein Sequence: MASSSAPVHPARYLSVFLVMLIGIYLLVFFTGDKHTAPKLGIDLQGGTRVTLTARTPDGSAPSREALAQAQQIISARVNGLGVSGSEVVVDGDNLVITVPGNDGSEARNLGQTARLYIRPVLNSMPAQPAAEEPQPAPSAEPQPPGQPAAPPPAQSGAPASPQPGAQPRPYPQDPAPSPNPTSPASPPPAPPAEAPATDPRKDLAERIAQEKKLRQSTNQYMQMVALQFQATRCESDDILAGNDDPKLPLVTCSTDHKTAYLLAPSIISGDQIQNATSGMDQRGIGYVVDLQFKGPAANIWADYTAAHIGTQTAFTLDSQVVSAPQIQEAIPGGRTQISGGDPPFTAATARQLANVLKYGSLPLSFEPSEAQTVSATLGLSSLRAGMIAGAIGLLLVLVYSLLYYRVLGLLTALSLVASGSMVFAILVLLGRYINYTLDLAGIAGLIIGIGTTADSFVVFFERIKDEIREGRSFRSAVPRGWARARKTIVSGNAVTFLAAAVLYFLAIGQVKGFAFTLGLTTILDLVVVFLVTWPLVYLASKSSLLAKPAYNGLGAVQQVARERRAMARTGRG
Mass: 60,267 Da
Length: 573 Aa

Rv2587c doesn't seem to be a targeted by any drug.

Protein export mtu03060
mtu03060
Genetic Information Processing; Folding, sorting and degradation

Bacterial secretion system mtu03070
mtu03070
Environmental Information Processing; Membrane transport

Tolerance of reactive oxygen produced by macrophages R-HSA-1222387
Homo sapiens
R-HSA-1222387

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.