Gene - combatTB X

yajC

Type: protein_coding
Name: yajC
Locus Name: Rv2588c
Product: Probable conserved membrane protein secretion factor YajC
Functional Category: Cell wall and cell processes
Location: 2915846..2916193 (- strand)
Gene Length: 347 bp
Nucleotides: ATGGAGAGTTTCGTTTTGTTCTTGCCGTTCCTGCTCATCATGGGTGGGTTCATGTACTTCGCGTCGCGCCGCCAGCGACGGGCCATGCAAGCCACCATCGATCTGCACGACTCGTTGCAGCCCGGGGAGCGGGTACACACGACTTCTGGGCTGGAAGCCACCATCGTCGCCATTGCCGACGACACCATCGACCTCGAGATCGCGCCCGGGGTGGTCACCACGTGGATGAAGTTGGCGATTCGTGACCGAATTCTGCCGGACGACGACATCGACGAGGAGCTCAACGAGGACCTTGACAAGGATGTTGACGACGTGGCCGGCGAGCGCCGGGTGACCAACGATTCCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. {ECO:0000250|UniProtKB:P0ADZ7}.

Family

YajC family

GO

protein transport GO:0015031 biological_process
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

IPR003849

UniProt: P9WL75
GenBank: Rv2588c
EnsemblBacteria: Rv2588c
Mycobrowser: Rv2588c

Summary

Name: Sec translocon accessory complex subunit YajC
Family: YajC family
Protein Sequence: MESFVLFLPFLLIMGGFMYFASRRQRRAMQATIDLHDSLQPGERVHTTSGLEATIVAIADDTIDLEIAPGVVTTWMKLAIRDRILPDDDIDEELNEDLDKDVDDVAGERRVTNDS
Mass: 12,967 Da
Length: 115 Aa

Rv2588c doesn't seem to be a targeted by any drug.

Bacterial secretion system mtu03070
mtu03070
Environmental Information Processing; Membrane transport

Protein export mtu03060
mtu03060
Genetic Information Processing; Folding, sorting and degradation

Quorum sensing mtu02024
mtu02024
Cellular Processes; Cellular community - prokaryotes

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.