PPE42
- Type
- protein_coding
- Name
- PPE42
- Locus Name
-
Rv2608
- Product
-
PPE family protein PPE42
- Functional Category
-
Pe/ppe
- Location
- 2935046..2936788 (+ strand)
- Gene Length
- 1742 bp
- Nucleotides
-
TGAATTTCGCCGTTTTGCCGCCGGAGGTGAATTCGGCGCGCATATTCGCCGGTGCGGGCCTGGGCCCAATGCTGGCGGCGGCGTCGGCCTGGGACGGGTTGGCCGAGGAGTTGCATGCCGCGGCGGGCTCGTTCGCGTCGGTGACCACCGGGTTGGCGGGCGACGCGTGGCATGGTCCGGCGTCGCTGGCGATGACCCGCGCGGCCAGCCCGTATGTGGGGTGGTTGAACACGGCGGCGGGTCAGGCCGCGCAGGCGGCCGGCCAGGCGCGGCTAGCGGCGAGCGCGTTCGAGGCGACGCTGGCGGCCACCGTGTCTCCAGCGATGGTCGCGGCCAACCGGACACGGCTGGCGTCGCTGGTGGCAGCCAACTTGCTGGGCCAGAACGCCCCGGCGATCGCGGCCGCGGAGGCTGAATACGAGCAGATATGGGCCCAGGACGTGGCCGCGATGTTCGGCTATCACTCCGCCGCGTCGGCGGTGGCCACGCAGCTGGCGCCTATTCAAGAGGGTTTGCAGCAGCAGCTGCAAAACGTGCTGGCCCAGTTGGCTAGCGGGAACCTGGGCAGCGGAAATGTGGGCGTCGGCAACATCGGCAACGACAACATTGGCAACGCAAACATCGGCTTCGGAAATCGAGGCGACGCCAACATCGGCATCGGGAATATCGGCGACAGAAACCTCGGCATTGGGAACACCGGCAATTGGAATATCGGCATCGGCATCACCGGCAACGGACAAATCGGCTTCGGCAAGCCTGCCAACCCCGACGTCTTGGTGGTGGGCAACGGCGGCCCGGGAGTAACCGCGTTGGTCATGGGCGGCACCGACAGCCTACTGCCGCTGCCCAACATCCCCTTACTCGAGTACGCTGCGCGGTTCATCACCCCCGTGCATCCCGGATACACCGCTACGTTCCTGGAAACGCCATCGCAGTTTTTCCCATTCACCGGGCTGAATAGCCTGACCTATGACGTCTCCGTGGCCCAGGGCGTAACGAATCTGCACACCGCGATCATGGCGCAACTCGCGGCGGGAAACGAAGTCGTCGTCTTCGGCACCTCCCAAAGCGCCACGATAGCCACCTTCGAAATGCGCTATCTGCAATCCCTGCCAGCACACCTGCGTCCGGGTCTCGACGAATTGTCCTTTACGTTGACCGGCAATCCCAACCGGCCCGACGGTGGCATTCTTACGCGTTTTGGCTTCTCCATACCGCAGTTGGGTTTCACATTGTCCGGCGCGACGCCCGCCGACGCCTACCCCACCGTCGATTACGCGTTCCAGTACGACGGCGTCAACGACTTCCCCAAATACCCGCTGAATGTCTTCGCGACCGCCAACGCGATCGCGGGCATCCTTTTCCTGCACTCCGGGTTGATTGCGTTGCCGCCCGATCTTGCCTCGGGCGTGGTTCAACCGGTGTCCTCACCGGACGTCCTGACCACCTACATCCTGCTGCCCAGCCAAGATCTGCCGCTGCTGGTCCCGCTGCGTGCTATCCCCCTGCTGGGAAACCCGCTTGCCGACCTCATCCAGCCGGACTTGCGGGTGCTCGTCGAGTTGGGTTATGACCGCACCGCCCACCAGGACGTGCCCAGCCCGTTCGGACTGTTTCCGGACGTCGATTGGGCCGAGGTGGCCGCGGACCTGCAGCAAGGCGCCGTGCAAGGCGTCAACGACGCCCTGTCCGGACTGGGGCTGCCGCCGCCGTGGCAGCCGGCGCTACCCCGACTTTTCTAA
- Drug Resistance
- Mutations
- Function
- Elicits a high humoral and a low T-cell response. Could be involved in directing the host toward development of a more humoral type of immune response. {ECO:0000269|PubMed:15346333}.
- Family
-
Mycobacterial PPE family
- GO
-
- positive regulation by symbiont of host immune response GO:0052556 biological_process
- InterPro
Summary
- Name
- Uncharacterized PPE family protein PPE42
- Family
- Mycobacterial PPE family
- Protein Sequence
-
MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGSFASVTTGLAGDAWHGPASLAMTRAASPYVGWLNTAAGQAAQAAGQARLAASAFEATLAATVSPAMVAANRTRLASLVAANLLGQNAPAIAAAEAEYEQIWAQDVAAMFGYHSAASAVATQLAPIQEGLQQQLQNVLAQLASGNLGSGNVGVGNIGNDNIGNANIGFGNRGDANIGIGNIGDRNLGIGNTGNWNIGIGITGNGQIGFGKPANPDVLVVGNGGPGVTALVMGGTDSLLPLPNIPLLEYAARFITPVHPGYTATFLETPSQFFPFTGLNSLTYDVSVAQGVTNLHTAIMAQLAAGNEVVVFGTSQSATIATFEMRYLQSLPAHLRPGLDELSFTLTGNPNRPDGGILTRFGFSIPQLGFTLSGATPADAYPTVDYAFQYDGVNDFPKYPLNVFATANAIAGILFLHSGLIALPPDLASGVVQPVSSPDVLTTYILLPSQDLPLLVPLRAIPLLGNPLADLIQPDLRVLVELGYDRTAHQDVPSPFGLFPDVDWAEVAADLQQGAVQGVNDALSGLGLPPPWQPALPRLF
- Mass
- 59,675 Da
- Length
- 580 Aa
Rv2608 doesn't seem to be a targeted by any drug.
Rv2608 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Regions of high antigenicity within the hypothetical PPE major polymorphic tandem repeat open-reading frame, Rv2608, show a differential humoral response and a low T cell response in various categories of patients with tuberculosis.
- J Infect Dis. 2004 Oct 1;190(7):1237-44. doi: 10.1086/423938. Epub 2004 Aug 18.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.