Gene - combatTB X

Rv2611c

Type: protein_coding
Name: Rv2611c
Locus Name: Rv2611c
Product: Probable acyltransferase
Functional Category: Lipid metabolism
Location: 2939012..2939962 (- strand)
Gene Length: 950 bp
Nucleotides: GTGATTGCCGGCCTTAAGGGCTTGAAGCTGCCCAAAGATCCGCGCAGTTCCGTGACGCGCACCGCGACCGACTGGGCGTATGCGGCCGGCTGGATGGCCGTACGGGCGCTGCCAGAGTTCGCCGTACGCAACGCATTCGACACCGGAGCGCGCTACTTTGCCCGCCACGGCGGGCCCGAGCAGCTGCGCAAGAACCTGGCCCGCGTCCTGGGTGTGCCGCCAGCCGCGGTGCCGGACCCGCTGATGTGCGCCTCGCTGGAGTCCTACGGGCGCTACTGGCGTGAGGTGTTCCGGCTGCCGACGATAAACCACCGCAAGCTGGCCCGCCAGCTCGACCGCGTGATCGGTGGACTGGATCACCTGGACGCGGCGCTGGCCGCGGGCCTCGGTGCCGTGCTGGCGTTGCCGCACAGCGGCAACTGGGATATGGCCGGGATGTGGCTGGTGCAGCGGCACGGCACCTTCACCACCGTCGCCGAGCGCCTAAAACCCGAATCGCTGTACCAGCGCTTTATCGACTACCGCGAAAGCCTGGGATTTGAGGTGCTGCCGCTGTCCGGCGGCGAACGGCCGCCGTTCGAGGTGCTCTCTGAGCGGCTGAGGAACAACCGAGTGGTCTGCCTGATGGCCGAGCGCGATCTCACCCGCACCGGTGTTGAGGTCGACTTCTTCGGCGAGCCCACCCGGATGCCGGTGGGGCCGGCGAAGCTGGCGGTCGAGACCGGTGCGGCATTGCTGCCCACACATTGCTGGTTCGAGGGCCGCGGCTGGGGTTTCCAGGTGTATCCGGCGCTGGATTGCACCAGCGGTGACGTCGCTGCCATCACACAGGCGCTGGCCGACCGCTTCGCGCAGAACATTGCCGCCCATCCCGCGGATTGGCACATGCTGCAGCCCCAGTGGCTGGCCGACTTATCCGAATCGCGGCGGGCGCAACTGAGGTCCAGATG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the acylation to the position 6 of the alpha-1,2-linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). {ECO:0000269|PubMed:12851411}.

Family

LpxL/LpxM/LpxP family

GO

phosphatidylinositol metabolic process GO:0046488 biological_process
glycolipid biosynthetic process GO:0009247 biological_process
plasma membrane GO:0005886 cellular_component
transferase activity, transferring acyl groups GO:0016746 molecular_function
integral component of membrane GO:0016021 cellular_component
membrane GO:0016020 cellular_component

InterPro

IPR004960

UniProt: P9WMB5
GenBank: Rv2611c
EnsemblBacteria: Rv2611c
Mycobrowser: Rv2611c

Summary

Name: Phosphatidylinositol mannoside acyltransferase (PIM acyltransferase) (EC 2.3.1.265)
Family: LpxL/LpxM/LpxP family
Protein Sequence: MIAGLKGLKLPKDPRSSVTRTATDWAYAAGWMAVRALPEFAVRNAFDTGARYFARHGGPEQLRKNLARVLGVPPAAVPDPLMCASLESYGRYWREVFRLPTINHRKLARQLDRVIGGLDHLDAALAAGLGAVLALPHSGNWDMAGMWLVQRHGTFTTVAERLKPESLYQRFIDYRESLGFEVLPLSGGERPPFEVLSERLRNNRVVCLMAERDLTRTGVEVDFFGEPTRMPVGPAKLAVETGAALLPTHCWFEGRGWGFQVYPALDCTSGDVAAITQALADRFAQNIAAHPADWHMLQPQWLADLSESRRAQLRSR
Mass: 35,126 Da
Length: 316 Aa

Rv2611c doesn't seem to be a targeted by any drug.

Lipoarabinomannan (LAM) biosynthesis mtu00571
mtu00571
Metabolism; Glycan biosynthesis and metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species.: J Biol Chem. 2003 Sep 19;278(38):36285-95. doi: 10.1074/jbc.M303639200. Epub 2003 Jul 8.
Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv.: Microbiology. 2002 Oct;148(Pt 10):2967-73. doi: 10.1099/00221287-148-10-2967.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.