Gene - combatTB X

Rv2613c

Type: protein_coding
Name: Rv2613c
Locus Name: Rv2613c
Product: Conserved protein
Functional Category: Lipid metabolism
Location: 2940609..2941196 (- strand)
Gene Length: 587 bp
Nucleotides: GTGAGTGACGAGGACCGCACGGATCGGGCCACCGAGGACCACACCATCTTCGATCGGGGTGTCGGCCAGCGCGACCAGCTGCAGCGGTTATGGACCCCCTACCGGATGAACTACCTGGCCGAAGCGCCAGTGAAGCGTGACCCCAATTCCTCGGCCAGCCCTGCGCAGCCGTTCACCGAGATCCCGCAGCTGTCCGACGAAGAGGGTCTGGTGGTCGCTCGTGGCAAGCTGGTCTACGCCGTGCTCAACCTGTACCCGTACAACCCCGGGCACTTGATGGTGGTGCCCTATCGTCGGGTATCCGAACTCGAGGATCTCACCGATTTGGAGAGCGCCGAGTTGATGGCGTTCACCCAGAAGGCGATTCGCGTGATCAAGAACGTGTCGCGTCCGCACGGCTTCAATGTCGGCCTGAACCTAGGGACATCGGCGGGCGGGTCGCTGGCCGAGCACCTGCACGTGCATGTGGTGCCACGGTGGGGTGGCGATGCGAATTTCATCACCATCATCGGGGGCTCCAAGGTGATTCCGCAGCTGCTGCGCGACACCCGTCGGCTGCTTGCCACCGAGTGGGCTCGGCAACCATG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues. {ECO:0000269|PubMed:19778616, ECO:0000269|PubMed:21565198}.

Family

Unknown

GO

diadenosine tetraphosphate catabolic process GO:0015967 biological_process
ATP adenylyltransferase activity GO:0003877 molecular_function
bis(5'-nucleosyl)-tetraphosphatase activity GO:0008796 molecular_function
ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component

InterPro

UniProt: P9WMK9
GenBank: Rv2613c
EnsemblBacteria: Rv2613c
Mycobrowser: Rv2613c

Summary

Name: AP-4-A phosphorylase (EC 2.7.7.53) (ATP adenylyltransferase) (Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase) (AP,A phosphorylase)
Family: Unknown
Protein Sequence: MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLLRDTRRLLATEWARQP
Mass: 21,869 Da
Length: 195 Aa

Rv2613c doesn't seem to be a targeted by any drug.

Purine metabolism mtu00230
mtu00230
PATHWAY_MAP mtu00230 Purine metabolism

Structural insights into the novel diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv.: J Mol Biol. 2011 Jul 1;410(1):93-104. doi: 10.1016/j.jmb.2011.04.059. Epub 2011 May 4.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Purification and molecular characterization of a novel diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv.: Protein Expr Purif. 2010 Jan;69(1):99-105. doi: 10.1016/j.pep.2009.09.010. Epub 2009 Sep 22.
Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv.: Microbiology. 2002 Oct;148(Pt 10):2967-73. doi: 10.1099/00221287-148-10-2967.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.