Rv2631
- Type
- protein_coding
- Name
- Rv2631
- Locus Name
-
Rv2631
- Product
-
Conserved hypothetical protein
- Functional Category
-
Conserved hypotheticals
- Location
- 2957572..2958870 (+ strand)
- Gene Length
- 1298 bp
- Nucleotides
-
TGCAAGTGGTCAACGTGGCTACGCTGCCGGGGATTGTCCGGGCCTCGTATGCGATGCCCGATGTGCACTGGGGATATGGTTTCCCAATCGGCGGCGTGGCCGCAACCGACGTCGACAATGATGGAGTCGTTTCCCCAGGCGGTGTCGGCTTCGATATTTCGTGCGGCGTAAGACTCTTGGTCGGCGAAGGGCTGGACCGCGAGGAGCTGCAACCACGGTTGCCGGCGGTCATGGACCGGCTTGATCGCGCGATACCGCGCGGAGTGGGCACGGCGGGTGTGTGGCGACTACCCGACCGGAACACGCTGCAGGAGGTGCTCACCGGTGGTGCCCGGTTTGCGGTGGAACAGGGGCATGGCGTCGCGCTAGACCTCGAGCGGTGCGAAGACGGCGGTGTGATGACAGGAGCGGACGCGGCCAAAATCAGTGACCGGGCCCTCCAACGCGGGCTTGGGCAGATCGGCAGCCTTGGCTCGGGCAACCACTTCCTGGAAGTCCAGGCCGTGGACCGCGTCTACGATCCGGTTGCGGCCGCGCCGATGGGTCTGGCGGAAGGGACCGTCTGCGTGATGATCCACACCGGCTCACGGGGCCTGGGCCATCAGATCTGCACGGATCACGTCCGCCAGATGGAACAAGCCATGGGCCGATACGGAATCGCGGTGCCCGATCGCCAATTGGCTTGTGTGCCGGTGCACTCCCCCGATGGGCAGGCCTATCTCGCCGCGATGGCGGCGGCGGCCAACTACGGACGCGCCAACCGCCAACTGCTGACCGAGGCGACGCGTCGTGTGTTCGCTGATGCAACCGGAACACCTCTGGACCTGCTCTACGACGTGTCGCACAACCTGGCCAAGATCGAGACGCATCCGATCGACGGTCAGCTGCGCTCGGTGTGCGTGCACCGCAAGGGCGCCACCCGCTCGCTGCCGCCGCACCATCACGAGCTGCCGGCCGAACTGGCAGCGGTCGGCCAACCCGTGCTGATACCCGGGACGATGGGTACGGCGTCATATGTGCTTGCCGGGGTCACCGGCAACCCGGCGTTCTTTTCCACCGCGCATGGTGCTGGGCGGGTACTGAGCCGTCACCAGGCCGCCCGCCACACCAGCGGTGAAGCGATACGCGCCAGCCTCGCAAAACGTGGCATCATCGTCCGCGGTACCTCTCGTAGGGGTATCGCCGAGGAAAAGCCGGAGGCCTACAAAGACGTCGACGAGGTCATCGAAGCCAGCCATCAGAGTGGCCTCGCGCGCAAAGTGGCTCGCCTTGTTCCCTTGGGCTGTGTCAAAGGATGA
- Drug Resistance
- Mutations
- Function
- RNA ligase that mediates the joining of broken tRNA-like stem-loop structures. {ECO:0000250}.
- Family
-
RtcB family
- GO
-
- metal ion binding GO:0046872 molecular_function
- tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate GO:0000971 biological_process
- RNA ligase (ATP) activity GO:0003972 molecular_function
- cell wall GO:0005618 cellular_component
- extracellular region GO:0005576 cellular_component
- tRNA splicing, via endonucleolytic cleavage and ligation GO:0006388 biological_process
- InterPro
Summary
- Name
- RNA-splicing ligase RtcB (EC 6.5.1.-)
- Family
- RtcB family
- Protein Sequence
-
MQVVNVATLPGIVRASYAMPDVHWGYGFPIGGVAATDVDNDGVVSPGGVGFDISCGVRLLVGEGLDREELQPRLPAVMDRLDRAIPRGVGTAGVWRLPDRNTLQEVLTGGARFAVEQGHGVALDLERCEDGGVMTGADAAKISDRALQRGLGQIGSLGSGNHFLEVQAVDRVYDPVAAAPMGLAEGTVCVMIHTGSRGLGHQICTDHVRQMEQAMGRYGIAVPDRQLACVPVHSPDGQAYLAAMAAAANYGRANRQLLTEATRRVFADATGTPLDLLYDVSHNLAKIETHPIDGQLRSVCVHRKGATRSLPPHHHELPAELAAVGQPVLIPGTMGTASYVLAGVTGNPAFFSTAHGAGRVLSRHQAARHTSGEAIRASLAKRGIIVRGTSRRGIAEEKPEAYKDVDEVIEASHQSGLARKVARLVPLGCVKG
- Mass
- 45,528 Da
- Length
- 432 Aa
Rv2631 doesn't seem to be a targeted by any drug.
Rv2631 doesn't seem to be involved in any pathway.
- Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.
- J Biol Chem. 2008 Jun 27;283(26):18032-9. doi: 10.1074/jbc.M802274200. Epub 2008 Apr 9.
- Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection.
- Cell Host Microbe. 2008 May 15;3(5):323-30. doi: 10.1016/j.chom.2008.03.007.
- Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.
- J Exp Med. 2003 Sep 1;198(5):705-13. doi: 10.1084/jem.20030205.
- Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv.
- Microbiology. 2002 Oct;148(Pt 10):2967-73. doi: 10.1099/00221287-148-10-2967.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.