suhB
- Type
- protein_coding
- Name
- suhB
- Locus Name
-
Rv2701c
- Product
-
Inositol-1-monophosphatase SuhB
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3015863..3016735 (- strand)
- Gene Length
- 872 bp
- Nucleotides
-
GTGACACGACCTGACAACGAACCCGCGCGGCTGCGCTCTGTGGCCGAAAACCTTGCTGCCGAGGCGGCGGCCTTCGTTCGCGGTCGTCGGGCCGAGGTTTTCGGCATCTCCAGGGCGGGCGACGGCGACGGCGCGGTGCGCGCGAAGAGCAGCCCGACCGATCCGGTGACCGTGGTCGACACCGACACGGAGCGGCTCTTGCGTGATCGGTTGGCTCAACTTCGGCCCGGTGACCCGATTCTCGGGGAGGAAGGTGGTGGTCCCGCCGACGTGACGGCTACACCCTCCGACCGGGTCACTTGGGTGCTCGACCCCATCGACGGCACGGTGAATTTCGTCTACGGCATCCCGGCGTACGCGGTGTCGATTGGGGCACAGGTTGGCGGCATCACGGTGGCGGGCGCGGTCGCCGACGTCGCCGCTCGCACGGTGTATTCGGCGGCGACGGGCCTCGGCGCACATCTCACCGATGAGCGGGGGAGACATGTGTTGCGGTGCACCGGTGTCGACGAGTTGTCGATGGCGTTGCTGGGTACCGGCTTCGGGTACTCGGTTCGGTGCCGCGAGAAGCAGGCAGAATTGCTGGCTCATGTTGTGCCGTTGGTCCGCGACGTGCGTCGGATCGGTTCTGCGGCGCTGGACTTGTGCATGGTAGCGGCGGGTCGGCTGGACGCCTACTACGAGCACGGGGTGCAGGTGTGGGACTGTGCGGCAGGTGCGTTGATCGCCGCTGAGGCGGGGGCCCGCGTGTTGTTGTCAACGCCGAGAGCGGGCGGCGCGGGGTTGGTGGTGGTGGCTGCCGCGCCCGGAATCGCCGACGAGCTGTTGGCGGCGCTACAGCGATTCAACGGCCTAGAGCCGATCCCGGACTG
- Drug Resistance
- Mutations
- Function
- Catalyzes the dephosphorylation of inositol 1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria. Is also able to hydrolyze a variety of polyol phosphates such as glucitol-6-phosphate, inositol 2-phosphate (I-2-P), glycerol-2-phosphate, and 2'-AMP, albeit with reduced efficiency. {ECO:0000269|PubMed:11914086}.
- Family
-
Inositol monophosphatase superfamily
- GO
-
- inositol phosphate dephosphorylation GO:0046855 biological_process
- phosphatidylinositol phosphorylation GO:0046854 biological_process
- signal transduction GO:0007165 biological_process
- magnesium ion binding GO:0000287 molecular_function
- inositol monophosphate 4-phosphatase activity GO:0052833 molecular_function
- inositol monophosphate 3-phosphatase activity GO:0052832 molecular_function
- inositol biosynthetic process GO:0006021 biological_process
- inositol monophosphate 1-phosphatase activity GO:0008934 molecular_function
- InterPro
2Q74
- Name
- Inositol-1-monophosphatase SuhB (I-1-Pase) (IMPase) (Inositol-1-phosphatase) (EC 3.1.3.25)
- Family
- Inositol monophosphatase superfamily
- Protein Sequence
-
MTRPDNEPARLRSVAENLAAEAAAFVRGRRAEVFGISRAGDGDGAVRAKSSPTDPVTVVDTDTERLLRDRLAQLRPGDPILGEEGGGPADVTATPSDRVTWVLDPIDGTVNFVYGIPAYAVSIGAQVGGITVAGAVADVAARTVYSAATGLGAHLTDERGRHVLRCTGVDELSMALLGTGFGYSVRCREKQAELLAHVVPLVRDVRRIGSAALDLCMVAAGRLDAYYEHGVQVWDCAAGALIAAEAGARVLLSTPRAGGAGLVVVAAAPGIADELLAALQRFNGLEPIPD
- Mass
- 30,027 Da
- Length
- 290 Aa
Summary
Rv2701c doesn't seem to be a targeted by any drug.
-
-
Streptomycin biosynthesis mtu00521
mtu00521Metabolism; Biosynthesis of other secondary metabolites
-
- Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+.
- BMC Struct Biol. 2007 Aug 28;7:55. doi: 10.1186/1472-6807-7-55.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis.
- BMC Microbiol. 2010 Feb 18;10:50. doi: 10.1186/1471-2180-10-50.
- Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis.
- Biochemistry. 2002 Apr 2;41(13):4392-8. doi: 10.1021/bi0160056.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.