Gene - combatTB X

hflX

Type: protein_coding
Name: hflX
Locus Name: Rv2725c
Product: Probable GTP-binding protein HflX
Functional Category: Intermediary metabolism and respiration
Location: 3037427..3038914 (- strand)
Gene Length: 1487 bp
Nucleotides: ATGCCGGCAAATTCAGATGCGCGGCCAGCTGCCACGTGCCACCATCGGGTACTGGCTATGACATATCCAGATCCGCCCCAGACGGGCCTTTCGGACTTCACACCGAGCCTCGGTGAGCTCGCACTCGAGGACAGATCGGCGCTGCGCCGGGTTGCCGGGTTGTCGACCGAGCTTGCCGACGTCTCCGAGGTGGAGTACCGCCAGCTGCGCCTGGAGCGGGTGGTGTTGGTGGGAGTGTGGACCGAGGGCAGCGCGGCTGACAACCGGGCAAGCCTGGCCGAGCTGGCGGCATTGGCCGAAACCGCCGGCTCCCAGGTGCTCGAAGGACTCATCCAGCGTCGCGACAAGCCCGACCCGTCGACCTACATCGGCTCGGGCAAAGCGGCCGAACTCCGCGAAGTGATCGTGGCGACCGGCGCCGACACCGTCATCTGCGACGGCGAACTGTCGCCGGCGCAGTTGACCGCCTTGGAAAAGGCTGTGCAGGTTAAGGTTATTGACCGCACCGCGCTGATCCTCGACATCTTTGCCCAGCATGCCACCAGCAGGGAGGGCAAAGCCCAGGTGTCGCTGGCTCAGATGGAGTACATGCTGCCGCGGCTGCGCGGCTGGGGTGAGTCGATGTCACGGCAGGCGGGCGGTCGCGCCGGTGGCAGTGGTGGCGGGGTGGGTCTGCGCGGTCCCGGTGAGACCAAGATCGAGACTGACCGACGCCGCATCCGCGAGCGGATGGCCAAGTTACGGCGCGACATCAGGGCCATGAAACAGGTCCGCGACACCCAGCGCAGCCGTCGCCGGCACAGTGACGTGCCGTCGATCGCGATTGTCGGCTACACCAACGCGGGTAAGTCCAGCCTGCTCAACGCGCTGACCGGGGCCGGGGTGCTGGTACAGGACGCGCTGTTTGCCACCCTGGAACCCACCACCAGGCGCGCGGAGTTCGGTGACGGTAGGCCAGTCGTGCTCACCGACACCGTCGGCTTTGTGCGGCACCTGCCCACCCAGTTGGTCGAGGCGTTTCGCTCCACGCTGGAGGAGGTCGTGCACGCCGATCTATTGGTCCACGTCGTGGACGGATCCGACGGCCACCCGCTAGCCCAGATCGACGCGGTCCGTCAGGTGATCTCCGAGGTGATCGCCGACCATGACGGCGATCCGCCGCCCGAGCTGCTGGTAGTGAACAAGGTTGACGTCGCTAGCGACCTGATGCTGGCCAAGCTGCGGCACGGGCTGCCCGGCGCGGTGTTCGTTTCCGCCCGCACCGGCGACGGTATCGATGCGCTCCGACGGCGGATGGCCGAGCTGGTTGTGCCCGCCGACACCGCCGTCGACGTGGTGATCCCGTACGACCGCGGCGACCTGGTGGCCCGTGTGCACGCCGATGGGCGGATACAGCAGGCGGAGCACAAGCCCGAGGGCACCCGGATCAAGGCCCGTGTCCCGGAGGCGCTGGCTGCCACCTTGCGCGAGTTTGCGCCGCGAGCGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. {ECO:0000256|HAMAP-Rule:MF_00900}.

Family

TRAFAC class OBG-HflX-like GTPase superfamily, HflX GTPase family

GO

GTPase activity GO:0003924 molecular_function
ribosome binding GO:0043022 molecular_function
GTP binding GO:0005525 molecular_function
plasma membrane GO:0005886 cellular_component
cytoplasm GO:0005737 cellular_component

InterPro

UniProt: O33230
GenBank: Rv2725c
EnsemblBacteria: Rv2725c
Mycobrowser: Rv2725c

Summary

Name: GTPase HflX (GTP-binding protein HflX)
Family: TRAFAC class OBG-HflX-like GTPase superfamily, HflX GTPase family
Protein Sequence: MPANSDARPAATCHHRVLAMTYPDPPQTGLSDFTPSLGELALEDRSALRRVAGLSTELADVSEVEYRQLRLERVVLVGVWTEGSAADNRASLAELAALAETAGSQVLEGLIQRRDKPDPSTYIGSGKAAELREVIVATGADTVICDGELSPAQLTALEKAVQVKVIDRTALILDIFAQHATSREGKAQVSLAQMEYMLPRLRGWGESMSRQAGGRAGGSGGGVGLRGPGETKIETDRRRIRERMAKLRRDIRAMKQVRDTQRSRRRHSDVPSIAIVGYTNAGKSSLLNALTGAGVLVQDALFATLEPTTRRAEFGDGRPVVLTDTVGFVRHLPTQLVEAFRSTLEEVVHADLLVHVVDGSDGHPLAQIDAVRQVISEVIADHDGDPPPELLVVNKVDVASDLMLAKLRHGLPGAVFVSARTGDGIDALRRRMAELVVPADTAVDVVIPYDRGDLVARVHADGRIQQAEHKPEGTRIKARVPEALAATLREFAPRA
Mass: 53,328 Da
Length: 495 Aa

Rv2725c doesn't seem to be a targeted by any drug.

Rv2725c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.