PE_PGRS47
- Type
- protein_coding
- Name
- PE_PGRS47
- Locus Name
-
Rv2741
- Product
-
PE-PGRS family protein PE_PGRS47
- Functional Category
-
Pe/ppe
- Location
- 3053914..3055491 (+ strand)
- Gene Length
- 1577 bp
- Nucleotides
-
TGTCATTTGTGATCGCGGCACCGGAGTTTTTAACGGCGGCAGCAATGGACTTGGCGAGCATCGGCTCGACAGTGAGCGCGGCCAGTGCCGCCGCATCAGCCCCCACGGTCGCGATCCTGGCCGCGGGCGCCGATGAGGTGTCGATAGCCGTCGCGGCGCTGTTCGGAATGCATGGCCAGGCATATCAGGCCCTCAGCGTGCAGGCATCGGCGTTTCATCAGCAATTTGTGCAGGCCTTGACCGCGGGCGCGTACTCGTATGCCTCCGCTGAAGCCGCCGCCGTGACACCGCTTCAGCAACTAGTCGATGTGATAAATGCGCCCTTCAGAAGCGCGCTCGGCCGCCCCCTGATCGGCAACGGCGCCAACGGTAAACCGGGGACCGGACAAGACGGCGGGGCCGGCGGACTCTTGTACGGCAGCGGCGGTAACGGGGGATCAGGGCTGGCCGGCTCCGGCCAGAAGGGCGGTAACGGAGGAGCTGCCGGATTGTTTGGCAACGGCGGGGCCGGCGGTGCCGGCGCGTCCAACCAAGCCGGCAACGGCGGCGCCGGCGGAAACGGCGGCGCCGGTGGGCTGATCTGGGGCACCGCGGGGACCGGTGGCAACGGCGGGTTCACCACCTTTCTTGATGCCGCTGGGGGTGCCGGCGGGGCCGGCGGCGCCGGTGGGCTGTTCGGCGCGGGCGGGGCCGGCGGCGTAGGCGGCGCCGCCCTCGGCGGCGGCGCCCAGGCCGCCGGTGGCAACGGCGGTGCGGGCGGGGTCGGTGGGCTGTTCGGCGCCGGCGGTGCCGGCGGCGCCGGCGGCTTCAGCGACACCGGTGGGACCGGCGGGGCTGGCGGGGCCGGCGGGCTGTTCGGCCCGGGCGGCGGCTCGGGCGGCGTCGGTGGCTTCGGCGACACCGGTGGGACCGGCGGCGACGGCGGCAGCGGCGGGCTGTTTGGCGTCGGCGGGGCCGGCGGGCACGGTGGCTTCGGCAGTGCTGCCGGCGGCGACGGCGGCGCGGGCGGCGCCGGCGGCACGGTCTTCGGCTCGGGCGGGGCCGGCGGTGCAGGCGGAGTCGCCACTGTCGCTGGCCACGGTGGTCACGGCGGTAATGCCGGCCTGCTATACGGCACCGGTGGGGCCGGCGGAGCCGGCGGGTTCGGCGGGTTCGGCGGCGACGGCGGCGACGGCGGTATCGGCGGGTTGGTCGGTTCTGGCGGCGCCGGCGGCAGCGGCGGCACCGGTACCCTAAGTGGTGGTCGCGGCGGGGCCGGCGGTAACGCCGGCACGTTCTACGGTTCCGGCGGCGCCGGCGGCGCCGGCGGGGAGAGCGACAACGGCGACGGCGGAAACGGCGGCGTGGGCGGCAAGGCCGGGTTGGTCGGCGAGGGCGGCAACGGCGGCGACGGCGGTGCCACGATAGCAGGAAAGGGTGGTAGCGGCGGTAACGGCGGCAACGCCTGGCTGACGGGCCAGGGCGGCAACGGCGGCAACGCCGCATTTGGCAAAGCCGGGACTGGCAGCGTCGGCGTCGGTGGCGCCGGCGGGCTGCTGGAGGGCCAGAACGGCGAGAACGGATTGCTGCCTAGCTGA
- Drug Resistance
- Mutations
- Function
- Contributes to evasion of both innate and adaptive immunity. Inhibits autophagy in infected host phagocytes and inhibits major histocompatibility complex (MHC) class II antigen presentation by mycobacteria-infected dendritic cells. Has an important role in the growth and survival of M.tuberculosis, particularly during intracellular growth and in the later chronic phase of infection. {ECO:0000269|PubMed:27562263}.
- Family
-
Mycobacterial PE family, PGRS subfamily
- GO
-
- cell surface GO:0009986 cellular_component
- host cell cytosol GO:0044164 cellular_component
- pathogenesis GO:0009405 biological_process
- extracellular region GO:0005576 cellular_component
- InterPro
Summary
- Name
- PE-PGRS family protein PE_PGRS47
- Family
- Mycobacterial PE family, PGRS subfamily
- Protein Sequence
-
MSFVIAAPEFLTAAAMDLASIGSTVSAASAAASAPTVAILAAGADEVSIAVAALFGMHGQAYQALSVQASAFHQQFVQALTAGAYSYASAEAAAVTPLQQLVDVINAPFRSALGRPLIGNGANGKPGTGQDGGAGGLLYGSGGNGGSGLAGSGQKGGNGGAAGLFGNGGAGGAGASNQAGNGGAGGNGGAGGLIWGTAGTGGNGGFTTFLDAAGGAGGAGGAGGLFGAGGAGGVGGAALGGGAQAAGGNGGAGGVGGLFGAGGAGGAGGFSDTGGTGGAGGAGGLFGPGGGSGGVGGFGDTGGTGGDGGSGGLFGVGGAGGHGGFGSAAGGDGGAGGAGGTVFGSGGAGGAGGVATVAGHGGHGGNAGLLYGTGGAGGAGGFGGFGGDGGDGGIGGLVGSGGAGGSGGTGTLSGGRGGAGGNAGTFYGSGGAGGAGGESDNGDGGNGGVGGKAGLVGEGGNGGDGGATIAGKGGSGGNGGNAWLTGQGGNGGNAAFGKAGTGSVGVGGAGGLLEGQNGENGLLPS
- Mass
- 44,210 Da
- Length
- 525 Aa
Rv2741 doesn't seem to be a targeted by any drug.
Rv2741 doesn't seem to be involved in any pathway.
- Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.
- Nat Microbiol. 2016 Aug 15;1(9):16133. doi: 10.1038/nmicrobiol.2016.133.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.