Gene - combatTB X

ftsK

Type: protein_coding
Name: ftsK
Locus Name: Rv2748c
Product: Possible cell division transmembrane protein FtsK
Functional Category: Cell wall and cell processes
Location: 3059855..3062506 (- strand)
Gene Length: 2651 bp
Nucleotides: ATGCTGGGGCCTCCTGGAACTCCGCGCGTCGGGCGGCGTGACGCGGCACGATCACTTGTCACCCTACTCAGGAGACCCTGGCAACGAGGCGAGCAGATCGCCGTTACCAGTGTGGCGGATGGTGTAGATGGTGTGATAGCGACTAGGCTTGCCGTTATGTCTAGCAAGACCGTTGCCCGCTCCGGCACTCGAACGAGCAGGTCAAAGGCCACTTCGCGGGGCGCGTCCCGAAGTGCGCGATCGGCCGTGCCCAGAAAGAGGTCGAGGCCCGTCAAAGGGGTCGGCAGACCCTCCCGACGGCACCATCGGTCGCTGCTGGTGTCTACCGGACTCGCCTGCGGCCGGGCCATGCGTGCCGTCTGGATGATGGCGGCCAAGGGCACCGGCGGCGCGGCGCGGTCGATCGGGCGAGCCCGCGACATCGAGCCCGGGCATCGCCGCGACGGAATCGCGCTGGTGCTGCTCGGCCTTGCCGTGGTAGTCGCCGCGAGCTCGTGGTTCGACGCCGCCCGGCCGCTCGGCGCGTGGGTCGACGCCTTGTTGCGGACGTTCATCGGGTCGGCAGTGGTCATGCTCCCGCTGGTTGCCGCCGCCGTGGCCGTGGTGCTGATGCGTACGTCGCCCAACCCCGATTCGCGGCCGCGGCTGATCCTCGGCGCCAGCCTGATCGGCTTGTCGTTTCTCGGCTTGTGCCACCTGTGGGCGGGCTCACCCGAGGCCCCGGAGTCGCGTTTGCGCGCCGCGGGGTTCATCGGTTTCGCGATCGGCGGGCCGCTCTCGGACGGGTTGACCGCCTGGATCGCCGCGCCGCTGTTATTCATCGGCGCGCTGTTCGGATTGCTCCTGCTGGCCGGGATCACGATCCGAGAGGTGCCAGATGCCATGCGCGCCATGTTCGGCACCCGGCTGTTGCCACGGGAATACGCCGACGACTTCGAGGACTTCGCGGACTTCGATGGTGACGACGCGGACACCGTCGAAGTCGCCCGCCAGGACTTCTCCGACGGTTACTACGACGAGGTGCCCCTGTGCTCCGACGACGGGCCACCGGCCTGGCCGTCGGCCGAGGTTCCGCAGGATGACACTGCGACGATACCGGAAGCCTCCGCCGGTCGGGGCTCCGGAAGACGCGGCCGCCGCAAAGATACCCAAGTGCTGGACCGGATCGTCGAGGGTCCCTACACGCTGCCGTCGCTGGACCTGCTGATATCCGGTGATCCGCCCAAGAAACGCAGTGCGGCCAACACCCACATGGCCGGCGCCATCGGTGAGGTGCTGACCCAGTTCAAGGTCGACGCGGCCGTCACGGGCTGCACCCGCGGGCCCACCGTCACCCGCTACGAGGTCGAACTGGGGCCCGGCGTCAAGGTCGAGAAGATCACCGCGCTGCAGCGCAACATCGCCTACGCGGTGGCTACCGAGAGCGTGCGCATGCTGGCACCGATCCCCGGCAAGTCCGCCGTCGGCATCGAGGTACCCAACACCGACCGGGAAATGGTGCGGTTGGCCGACGTGCTCACCGCACGAGAGACCCGTCGCGACCATCATCCGTTGGTGATCGGGCTGGGCAAGGACATCGAAGGCGACTTCATCTCGGCCAACCTGGCCAAGATGCCGCACCTGCTGGTGGCCGGCTCGACGGGCTCGGGAAAGTCCAGCTTCGTCAACTCCATGCTGGTGTCGCTGTTGACCCGGGCCACCCCGGAAGAGGTCAGGATGATCCTGATCGACCCGAAGATGGTGGAACTGACGCCGTATGAAGGCATTCCGCATCTGATCACGCCGATCATCACCCAGCCGAAGAAGGCCGCGGCCGCGCTGGCCTGGCTGGTCGACGAGATGGAGCAGCGCTACCAGGACATGCAGGCCTCCCGGGTGCGCCACATCGACGACTTCAACGACAAGGTGCGATCCGGGGCCATCACCGCGCCGCTGGGCAGCCAGCGCGAGTATCGGCCCTACCCCTACGTGGTGGCCATCGTCGACGAGTTGGCCGACCTCATGATGACCGCGCCGCGTGACGTCGAGGACGCCATCGTGCGGATCACCCAGAAAGCCCGCGCCGCCGGCATCCACCTGGTGCTGGCCACCCAGCGCCCGTCGGTGGACGTGGTCACCGGGCTGATCAAGACCAACGTGCCGTCGCGGCTGGCGTTTGCCACCTCGTCGCTGACCGACAGCCGGGTGATCCTGGACCAGGCGGGCGCGGAAAAGCTGATCGGCATGGGCGACGGCCTGTTCTTGCCGATGGGTGCGAGCAAACCCCTCCGGCTGCAGGGCGCTTACGTCTCCGACGAAGAGATCCACGCCGTCGTCACCGCCTGCAAGGAACAGGCCGAACCCGAATACACCGAGGGCGTCACCACGGCTAAACCCACCGCGGAGCGCACCGACGTCGACCCCGACATCGGCGACGACATGGACGTCTTCCTGCAGGCCGTGGAACTGGTGGTGTCCAGCCAGTTCGGGTCGACGTCGATGCTGCAGCGCAAGCTGCGGGTCGGCTTCGCCAAAGCGGGCCGTTTGATGGACCTGATGGAGACCCGCGGCATCGTCGGGCCCAGCGAAGGCTCGAAGGCCCGTGAGGTGCTGGTCAAGCCCGACGAGTTGGCGGGCACACTGGCCGCGATCCGGGGTGACGGCGGCGAGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). {ECO:0000250}.

Family

FtsK/SpoIIIE/SftA family

GO

cell cycle GO:0007049 biological_process
chromosome segregation GO:0007059 biological_process
cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component
ATP binding GO:0005524 molecular_function
cytosol GO:0005829 cellular_component
DNA binding GO:0003677 molecular_function
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component
cell division GO:0051301 biological_process

InterPro

UniProt: P9WNA3
GenBank: Rv2748c
EnsemblBacteria: Rv2748c
Mycobrowser: Rv2748c

Summary

Name: DNA translocase FtsK
Family: FtsK/SpoIIIE/SftA family
Protein Sequence: MSSKTVARSGTRTSRSKATSRGASRSARSAVPRKRSRPVKGVGRPSRRHHRSLLVSTGLACGRAMRAVWMMAAKGTGGAARSIGRARDIEPGHRRDGIALVLLGLAVVVAASSWFDAARPLGAWVDALLRTFIGSAVVMLPLVAAAVAVVLMRTSPNPDSRPRLILGASLIGLSFLGLCHLWAGSPEAPESRLRAAGFIGFAIGGPLSDGLTAWIAAPLLFIGALFGLLLLAGITIREVPDAMRAMFGTRLLPREYADDFEDFADFDGDDADTVEVARQDFSDGYYDEVPLCSDDGPPAWPSAEVPQDDTATIPEASAGRGSGRRGRRKDTQVLDRIVEGPYTLPSLDLLISGDPPKKRSAANTHMAGAIGEVLTQFKVDAAVTGCTRGPTVTRYEVELGPGVKVEKITALQRNIAYAVATESVRMLAPIPGKSAVGIEVPNTDREMVRLADVLTARETRRDHHPLVIGLGKDIEGDFISANLAKMPHLLVAGSTGSGKSSFVNSMLVSLLTRATPEEVRMILIDPKMVELTPYEGIPHLITPIITQPKKAAAALAWLVDEMEQRYQDMQASRVRHIDDFNDKVRSGAITAPLGSQREYRPYPYVVAIVDELADLMMTAPRDVEDAIVRITQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQAGAEKLIGMGDGLFLPMGASKPLRLQGAYVSDEEIHAVVTACKEQAEPEYTEGVTTAKPTAERTDVDPDIGDDMDVFLQAVELVVSSQFGSTSMLQRKLRVGFAKAGRLMDLMETRGIVGPSEGSKAREVLVKPDELAGTLAAIRGDGGE
Mass: 88,887 Da
Length: 831 Aa

Rv2748c doesn't seem to be a targeted by any drug.

Rv2748c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.