Gene - combatTB X

ltp1

Type: protein_coding
Name: ltp1
Locus Name: Rv2790c
Product: Probable lipid-transfer protein Ltp1
Functional Category: Cell wall and cell processes
Location: 3098964..3100169 (- strand)
Gene Length: 1205 bp
Nucleotides: ATGCCTAACCAAGGGTCGTCGAACAAGGTTTACGTCATTGGCGTGGGCATGACGAAGTTCGAAAAGCCCGGGCGACGCGAAGGCTGGGACTACCCGGACATGGCCAGGGAGTCGGGCACCAAAGCGCTGCGCGACGCCGGCATCGACTACCGCGAAGTTGAACAGGGCTACGTCGGCTACGTCTACGGAGAATCGACGTCGGGTCAGCGGGCGCTCTACGAACTCGGCATGACGGGTATCCCCATCGTCAACGTCAACAACAACTGCTCGACCGGATCCACGGCGCTCTACCTCGGCGCGCAGGCCATCCGCGGCGGACTGGCCGATTGCGTGTTGGCGCTGGGCTTCGAGAAGATGCAGCCCGGAGCGCTGGGCGGTGGCGCCGACGACCGGGAGTCGCCGCTGGGCAGGCACGTCAAGGCGTTAGCCGAGATCGACGAGTTCGGCTTTCCGGTGGCGCCGTGGATGTTCGGGGCGGCCGGCCGCGAACACATGAAGAAATACGGCACCACCGCGGAGCATTTCGCGAAGATCGGCTACAAGAACCACAAGCACTCGGTCAACAACCCGTATGCACAGTTTCAGGACGAATACACCCTGGACGACATCTTGGCCTCAAAGATGATTTCCGACCCGCTGACCAAATTGCAGTGCTCTCCCACCTCCGACGGGTCGGCGGCGGTGGTGCTGGCCAGTGAGGATTACCTGGCCAACCACAACCTTGCCGGGCGGGCTGTGGAAATCGTCGGGCAGGCGATGACCACCGACTTCGCTTCCACCTTTGATGGCAGTGCCCGCAATATCATCGGCTACGACATGACTGTGCAAGCGGCACAACGGGTTTACCAGCAATCCGGACTCGGCCCGAAGGACTTCGGAGTGATCGAGCTGCACGACTGCTTCTCAGCCAACGAGCTACTGCTCTACGAGGCGCTCGGCCTGTGCGGGCCGGGCGAGGCGCCCGAGCTGATCGACGACAACCAGACCACCTACGGCGGACGCTGGGTCGTCAACCCATCCGGTGGGCTGATCTCCAAGGGCCATCCGCTGGGTGCGACGGGGTTGGCGCAGTGCGCGGAGCTGACCTGGCAGCTGCGCGGCACCGCCGAGGCGCGCCAGGTCGACAACGTGACCGCCGCGCTGCAACACAACATCGGGCTGGGCGGCGCCGCCGTGGTCACCGCATACCAACGGGCCGAACGTTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Thiolase-like superfamily, Thiolase family

GO

acetyl-CoA C-acyltransferase activity GO:0003988 molecular_function
acetyl-CoA C-acetyltransferase activity GO:0003985 molecular_function
cell wall GO:0005618 cellular_component
fatty acid beta-oxidation GO:0006635 biological_process

InterPro

UniProt: O33332
GenBank: Rv2790c
EnsemblBacteria: Rv2790c
Mycobrowser: Rv2790c

Summary

Name: Probable lipid-transfer protein Ltp1
Family: Thiolase-like superfamily, Thiolase family
Protein Sequence: MPNQGSSNKVYVIGVGMTKFEKPGRREGWDYPDMARESGTKALRDAGIDYREVEQGYVGYVYGESTSGQRALYELGMTGIPIVNVNNNCSTGSTALYLGAQAIRGGLADCVLALGFEKMQPGALGGGADDRESPLGRHVKALAEIDEFGFPVAPWMFGAAGREHMKKYGTTAEHFAKIGYKNHKHSVNNPYAQFQDEYTLDDILASKMISDPLTKLQCSPTSDGSAAVVLASEDYLANHNLAGRAVEIVGQAMTTDFASTFDGSARNIIGYDMTVQAAQRVYQQSGLGPKDFGVIELHDCFSANELLLYEALGLCGPGEAPELIDDNQTTYGGRWVVNPSGGLISKGHPLGATGLAQCAELTWQLRGTAEARQVDNVTAALQHNIGLGGAAVVTAYQRAER
Mass: 42,904 Da
Length: 401 Aa

Rv2790c doesn't seem to be a targeted by any drug.

Benzoate degradation mtu00362
mtu00362
PATHWAY_MAP mtu00362 Benzoate degradation

Valine, leucine and isoleucine degradation mtu00280
mtu00280
PATHWAY_MAP mtu00280 Valine, leucine and isoleucine degradation

Fatty acid degradation mtu00071
mtu00071
PATHWAY_MAP mtu00071 Fatty acid degradation

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.