Rv2819c
- Type
- protein_coding
- Name
- Rv2819c
- Locus Name
-
Rv2819c
- Product
-
Hypothetical protein
- Functional Category
-
Conserved hypotheticals
- Location
- 3126240..3127367 (- strand)
- Gene Length
- 1127 bp
- Nucleotides
-
ATGAACACCTACCTGAAGCCGTTCGAACTCACGCTGCGGTGCCTGGGGCCGGTGTTTATCGGATCCGGCGAGAAGCGGACCTCGAAGGAGTACCACGTGGAGGGCGACCGGGTCTACTTCCCGGACATGGAACTTCTTTACGCAGACATTCCGGCTCACAAGAGGAAGTCTTTCGAAGCGTTCGTCATGAACACCGATGGGGCACAGGCGACGGCGCCACTCAAAGAGTGGGTAGAGCCAAACGCGGTCAAGCTGGATCCTGCTAAGCATCGAGGTTACGAGGTGAAGATCGGGTCGATCGAACCGCGACGTGCATCTCGTGGTCGAGGCGGGCGCATGACTCGAAAGAAGCTTACGCTCAACGAGATTCACGCTTTCATCAAAGACCCTCTTGGAAGGCCCTACGTGCCGGGTTCGACTGTCAAGGGAATGCTTCGCAGCATCTACCTGCAGTCGCTTGTGCATAAGCGGACGGCCCAACCTGTTCGTGTTCCGGGACACCAGACGCGGGAGCACCGGCAGTACGGCGAAAGGTTTGAGCGGAAGGAGTTGCGCAAATCGGGGCGCCCCAACACCCGTCCGCAAGACGCGGTCAACGACCTGTTTCAGGCGATCAGGGTCACCGACTCACCTGCACTGAGAACAAGCGATCTGCTGATCTGCCAGAAGATGGACATGAATGTCCACGGCAAGCCTGATGGCCTGCCGCTCTTCCGGGAATGTTTGGCGCCGGGAACCTCAATCTCGCACCGCGTGGTGGTCGACACCAGTCCCACCGCTCGCGGCGGCTGGCGTGAGGGCGAGCGGTTCCTTGAAACGCTGGCCGAGACAGCCGCGTCCGTGAATCAGGCGCGTTACGCGGAGTACAGAGCCATGTACCCTGGCGTGAACGCGATAGTTGGCCCAATTGTCTATCTGGGCGGCGGAGCCGGCTATCGGAGCAAGACCTTTGTCACCGACCAAGACGACATGGCGAAGGTGCTCGACGCCCAGTTCGGGAAGGTAGTCAAGCACGTCGACAAGACGCGCGAACTACGCGTCTCACCACTTGTCTTGAAGCGAACCAAGATCGACAACATATGCTACGAGATGGGTCAGTGCGAGCTGTCGATCAGGAGAGCCGAATG
- Drug Resistance
- Mutations
- Function
- CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions (PubMed:29979631). {ECO:0000269|PubMed:29979631, ECO:0000305|PubMed:29979631}.; FUNCTION: This subunit might be involved in maturation of a crRNA intermediate to its mature form. {ECO:0000250|UniProtKB:A0A0A7HF79}.
- Family
-
CRISPR-associated Csm5 family
- GO
-
- RNA binding GO:0003723 molecular_function
- cytosol GO:0005829 cellular_component
- plasma membrane GO:0005886 cellular_component
- defense response to virus GO:0051607 biological_process
- InterPro
Summary
- Name
- CRISPR system Cms protein Csm5 (CRISPR type III A-associated protein Csm5)
- Family
- CRISPR-associated Csm5 family
- Protein Sequence
-
MNTYLKPFELTLRCLGPVFIGSGEKRTSKEYHVEGDRVYFPDMELLYADIPAHKRKSFEAFVMNTDGAQATAPLKEWVEPNAVKLDPAKHRGYEVKIGSIEPRRASRGRGGRMTRKKLTLNEIHAFIKDPLGRPYVPGSTVKGMLRSIYLQSLVHKRTAQPVRVPGHQTREHRQYGERFERKELRKSGRPNTRPQDAVNDLFQAIRVTDSPALRTSDLLICQKMDMNVHGKPDGLPLFRECLAPGTSISHRVVVDTSPTARGGWREGERFLETLAETAASVNQARYAEYRAMYPGVNAIVGPIVYLGGGAGYRSKTFVTDQDDMAKVLDAQFGKVVKHVDKTRELRVSPLVLKRTKIDNICYEMGQCELSIRRAE
- Mass
- 42,340 Da
- Length
- 375 Aa
Rv2819c doesn't seem to be a targeted by any drug.
Rv2819c doesn't seem to be involved in any pathway.
- Mycobacterium tuberculosis type III-A CRISPR/Cas system crRNA and its maturation have atypical features.
- FASEB J. 2019 Jan;33(1):1496-1509. doi: 10.1096/fj.201800557RR. Epub 2018 Jul 6.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.