Function

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions (PubMed:29979631). {ECO:0000269|PubMed:29979631, ECO:0000305|PubMed:29979631}.; FUNCTION: This subunit is a single-strand-specific deoxyribonuclease (ssDNase) which digests both linear and circular ssDNA; it has both exo- and endonuclease activity. {ECO:0000250|UniProtKB:B6YWB8}.; FUNCTION: ssDNase activity is stimulated in the ternary Csm effector complex; binding of cognate target RNA activates the ssDNase, as the target RNA is degraded ssDNA activity decreases. {ECO:0000250|UniProtKB:A0A0A7HFE1}.; FUNCTION: When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids. {ECO:0000250|UniProtKB:A0A0A7HFE1}.

Family

CRISPR-associated Cas10/Csm1 family

GO

• RNA binding GO:0003723 molecular_function
• extracellular region GO:0005576 cellular_component
• ATP binding GO:0005524 molecular_function
• plasma membrane GO:0005886 cellular_component
• transferase activity GO:0016740 molecular_function
• defense response to virus GO:0051607 biological_process
• exonuclease activity GO:0004527 molecular_function
• endonuclease activity GO:0004519 molecular_function

InterPro

• IPR003607
• IPR000160
• IPR041062
• IPR013408

UniProt

P71629

GenBank

Rv2823c

EnsemblBacteria

Rv2823c

Mycobrowser

Rv2823c

Rv2823c doesn't seem to be a targeted by any drug.

Rv2823c doesn't seem to be involved in any pathway.