Function

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements (spacers) and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions (PubMed:29979631). {ECO:0000269|PubMed:29979631, ECO:0000305|PubMed:29979631}.; FUNCTION: Processes pre-crRNA into individual crRNA units; accurate cleavage of pre-crRNA depends on a 3' stem-loop and the sequence of the bases in the stem. The mature crRNA is unusual for type III-A systems as it doe snot undergo 3' processing after Cas6 cleavage. Mature crRNA is about 71 nucleotides (nt long) with an 8 nt 5' handle and 28 nt repeat with a 10 nt stem-loop at the 3' end. {ECO:0000269|PubMed:29979631}.

Family

CRISPR-associated protein Cas6/Cse3/CasE family

GO

• RNA binding GO:0003723 molecular_function
• defense response to virus GO:0051607 biological_process
• endonuclease activity GO:0004519 molecular_function

InterPro

• IPR010156
• IPR019267

UniProt

P9WPJ1

GenBank

Rv2824c

EnsemblBacteria

Rv2824c

Mycobrowser

Rv2824c

Rv2824c doesn't seem to be a targeted by any drug.

Rv2824c doesn't seem to be involved in any pathway.