Gene - combatTB X

Rv2837c

Type: protein_coding
Name: Rv2837c
Locus Name: Rv2837c
Product: Conserved protein
Functional Category: Conserved hypotheticals
Location: 3143635..3144645 (- strand)
Gene Length: 1010 bp
Nucleotides: GTGACGACGATCGACCCAAGGAGTGAGCTGGTCGACGGGCGGCGTCGCGCGGGGGCCCGCGTGGACGCCGTCGGTGCCGCTGCGCTGTTGTCGGCCGCTGCCAGGGTCGGGGTAGTCTGCCACGTCCACCCCGATGCCGACACCATCGGCGCCGGATTGGCATTGGCATTGGTGTTGGACGGGTGCGGCAAGCGGGTAGAGGTCAGCTTTGCCGCGCCGGCGACACTGCCCGAGTCGCTGCGTTCGCTGCCGGGCTGCCATCTGCTGGTCCGCCCTGAGGTGATGCGCCGCGATGTCGATTTGGTTGTGACTGTTGACATTCCGAGTGTTGATCGGCTCGGTGCTCTGGGCGATCTAACTGATTCCGGGCGGGAGCTCCTGGTAATCGACCATCACGCCTCCAACGACCTGTTCGGCACCGCGAATTTCATTGACCCGTCGGCGGATTCCACCACGACGATGGTTGCCGAGATCCTCGACGCGTGGGGGAAACCGATAGACCCGCGCGTCGCGCACTGCATCTACGCCGGGTTGGCGACCGACACGGGGTCGTTTCGCTGGGCCAGTGTGCGGGGGTATCGGCTGGCGGCGCGGCTGGTAGAGATCGGTGTGGACAACGCCACCGTCAGCAGGACCTTGATGGACAGCCATCCCTTCACCTGGTTGCCGTTGCTATCGCGGGTGTTGGGTTCGGCGCAGCTGGTGTCCGAGGCGGTCGGTGGCCGCGGGCTGGTTTACGTCGTCGTCGACAACCGGGAGTGGGTCGCTGCGCGCTCGGAGGAAGTGGAAAGCATCGTCGACATCGTCCGCACCACGCAACAAGCCGAGGTCGCGGCGGTGTTCAAGGAGGTCGAACCGCATCGGTGGTCGGTGTCGATGCGGGCTAAGACCGTGAATTTGGCCGCGGTTGCCTCTGGGTTCGGTGGCGGTGGTCACCGGCTGGCCGCGGGGTATACGACCACCGGCTCGATCGACGACGCTGTGGCGTCGTTGCGCGCGGCGCTTGGTTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Bifunctional enzyme which has both oligoribonuclease and pAp-phosphatase activities. Degrades RNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for 2-mers. Also degrades 24-mers. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. {ECO:0000269|PubMed:22114320}.

Family

NrnA oligoribonuclease family

GO

nucleic acid binding GO:0003676 molecular_function
3'(2'),5'-bisphosphate nucleotidase activity GO:0008441 molecular_function
exonuclease activity GO:0004527 molecular_function

InterPro

UniProt: P71615
GenBank: Rv2837c
EnsemblBacteria: Rv2837c
Mycobrowser: Rv2837c

Summary

Name: Bifunctional oligoribonuclease and PAP phosphatase NrnA (EC 3.1.-.-) (3'(2'),5'-bisphosphate nucleotidase) (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (nanoRNase)
Family: NrnA oligoribonuclease family
Protein Sequence: MTTIDPRSELVDGRRRAGARVDAVGAAALLSAAARVGVVCHVHPDADTIGAGLALALVLDGCGKRVEVSFAAPATLPESLRSLPGCHLLVRPEVMRRDVDLVVTVDIPSVDRLGALGDLTDSGRELLVIDHHASNDLFGTANFIDPSADSTTTMVAEILDAWGKPIDPRVAHCIYAGLATDTGSFRWASVRGYRLAARLVEIGVDNATVSRTLMDSHPFTWLPLLSRVLGSAQLVSEAVGGRGLVYVVVDNREWVAARSEEVESIVDIVRTTQQAEVAAVFKEVEPHRWSVSMRAKTVNLAAVASGFGGGGHRLAAGYTTTGSIDDAVASLRAALG
Mass: 35,415 Da
Length: 336 Aa

Rv2837c doesn't seem to be a targeted by any drug.

Rv2837c doesn't seem to be involved in any pathway.

targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Characterization of NrnA homologs from Mycobacterium tuberculosis and Mycoplasma pneumoniae.: RNA. 2012 Jan;18(1):155-65. doi: 10.1261/rna.029132.111. Epub 2011 Nov 23.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.