Gene - combatTB X

infB

Type: protein_coding
Name: infB
Locus Name: Rv2839c
Product: Probable translation initiation factor if-2 InfB
Functional Category: Information pathways
Location: 3145171..3147873 (- strand)
Gene Length: 2702 bp
Nucleotides: GTGGCAGCAGGTAAGGCCCGCGTACACGAGTTGGCTAAGGAACTCGGTGTAACCAGCAAGGAAGTTCTCGCCCGGCTGAGCGAGCAGGGCGAATTCGTCAAATCAGCATCGTCGACGGTGGAAGCACCGGTTGCCCGTCGGCTGCGTGAATCGTTCGGTGGCAGCAAACCTGCCCCGGCGAAAGGCACCGCCAAGTCCCCCGGCAAAGGCCCCGACAAGTCCCTTGACAAGGCGCTGGACGCCGCGATCGACATGGCCGCAGGCAACGGCAAGGCGACTGCCGCGCCCGCCAAGGCCGCCGATTCCGGCGGGGCGGCAATCGTCTCCCCAACTACCCCCGCCGCACCCGAGCCTCCGACCGCAGTGCCGCCCAGCCCTCAGGCACCCCACCCCGGCATGGCTCCCGGGGCGCGGCCGGGCCCGGTGCCGAAGCCGGGGATTCGCACCCCGCGCGTCGGCAACAACCCGTTCTCGTCGGCGCAACCCGCCGACCGGCCCATCCCGCGTCCGCCGGCTCCCCGCCCCGGTACCGCCCGGCCCGGGGTTCCACGTCCGGGCGCCTCGCCCGGCAGCATGCCGCCACGCCCCGGTGGAGCTGTCGGGGGTGCCCGTCCACCACGTCCTGGTGCGCCACGACCCGGGGGCCGGCCCGGTGCGCCCGGCGCTGGCCGTTCCGACGCGGGCGGCGGCAACTACCGGGGTGGCGGCGTGGGTGCCGCTCCCGGAACGGGCTTCCGCGGCCGTCCCGGGGGCGGCGGCGGTGGCCGTCCCGGGCAGCGTGGCGGTGCCGCCGGCGCGTTCGGCCGCCCGGGTGGTGCGCCCCGGCGCGGCCGCAAGTCCAAGCGGCAGAAGCGCCAGGAGTACGACTCGATGCAGGCTCCGGTCGTCGGCGGGGTGCGGTTGCCGCACGGCAACGGCGAAACGATCCGGCTCGCACGCGGCGCGTCGCTCAGCGACTTCGCGGACAAAATCGACGCCAACCCCGCGGCGCTGGTGCAGGCGCTGTTCAACCTCGGCGAGATGGTGACGGCCACCCAGTCGGTCGGCGACGAGACGCTGGAGTTGCTGGGCAGCGAGATGAACTACAACGTTCAGGTCGTCAGCCCGGAGGACGAAGACCGCGAGCTGCTGGAATCCTTCGACCTCAGCTACGGTGAGGACGAGGGCGGCGAGGAGGACCTTCAGGTTCGCCCGCCGGTGGTGACGGTGATGGGTCACGTCGACCACGGCAAGACCCGGCTGTTGGACACCATCCGCAAGGCCAACGTCCGCGAGGCCGAGGCCGGCGGCATCACCCAGCACATCGGTGCCTACCAGGTGGCCGTCGATCTGGACGGCAGCCAGCGGCTGATCACCTTTATCGACACCCCGGGCCACGAGGCGTTCACCGCCATGCGTGCCCGTGGCGCCAAGGCGACCGATATCGCCATTTTGGTGGTCGCCGCTGACGATGGAGTGATGCCGCAGACGGTCGAGGCCATCAACCACGCGCAGGCCGCCGACGTGCCGATCGTGGTGGCGGTCAACAAGATCGACAAGGAGGGTGCCGACCCGGCCAAGATTCGCGGGCAGCTTACCGAATATGGTTTAGTGCCAGAGGAATTCGGCGGTGACACGATGTTCGTCGACATCTCGGCCAAGCAGGGCACCAATATCGAGGCGCTGGAGGAGGCCGTGTTGCTGACCGCCGACGCCGCGCTGGACCTGCGGGCAAACCCCGACATGGAAGCCCAGGGTGTGGCGATCGAGGCGCACTTGGACCGTGGTCGCGGCCCAGTGGCTACCGTGCTGGTGCAGCGCGGCACCCTGCGGGTCGGTGACTCGGTGGTCGCCGGCGACGCCTATGGCCGTGTTCGCCGCATGGTCGACGAACACGGCGAAGACGTCGAGGTTGCGCTGCCGTCGCGGCCTGTGCAGGTCATTGGCTTCACGTCGGTGCCCGGCGCCGGCGACAACTTCCTCGTCGTCGACGAGGACCGTATCGCCCGCCAAATCGCCGACCGGCGTAGCGCTCGCAAGCGCAACGCCCTGGCGGCGCGCTCACGCAAGCGGATCAGCCTGGAGGACCTGGACTCGGCGCTGAAGGAAACCAGCCAGCTGAACCTGATCCTCAAGGGCGACAACGCCGGTACCGTCGAGGCGCTGGAAGAGGCCCTGATGGGTATCCAGGTGGACGACGAGGTGGTGCTGCGGGTGATCGACCGCGGTGTCGGCGGCATTACCGAAACCAACGTCAACCTGGCGTCGGCTTCCGATGCGGTGATCATCGGTTTCAATGTGCGCGCCGAAGGCAAGGCGACCGAGCTGGCCAGCCGCGAAGGCGTGGAGATCCGCTACTACTCGGTCATCTACCAGGCGATCGACGAGATCGAGCAGGCGCTGCGTGGCCTGCTCAAGCCGATCTACGAGGAAAACCAGCTGGGTCGGGCTGAGATCCGGGCGTTGTTCCGGTCTTCGAAGGTCGGCCTCATCGCCGGCTGCCTGGTCACCTCGGGTGTGATGCGGCGCAACGCCAAGGCGCGGCTGTTGCGGGACAACATCGTGGTCGCCGAGAACCTTTCGATCGCTTCGCTGCGCCGGGAGAAGGACGACGTGACCGAGGTGCGCGACGGCTTCGAGTGTGGCCTGACACTGGGTTACGCCGACATCAAGGAGGGCGACGTCATCGAGTCCTACGAGCTGGTCCAGAAGGAACGCGCCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity). {ECO:0000250}.

Family

TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, IF-2 subfamily

GO

translation initiation factor activity GO:0003743 molecular_function
GTPase activity GO:0003924 molecular_function
cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component
GTP binding GO:0005525 molecular_function
plasma membrane GO:0005886 cellular_component
cytoplasm GO:0005737 cellular_component
translational initiation GO:0006413 biological_process

InterPro

UniProt: P9WKK1
GenBank: Rv2839c
EnsemblBacteria: Rv2839c
Mycobrowser: Rv2839c

Summary

Name: Translation initiation factor IF-2
Family: TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, IF-2 subfamily
Protein Sequence: MAAGKARVHELAKELGVTSKEVLARLSEQGEFVKSASSTVEAPVARRLRESFGGSKPAPAKGTAKSPGKGPDKSLDKALDAAIDMAAGNGKATAAPAKAADSGGAAIVSPTTPAAPEPPTAVPPSPQAPHPGMAPGARPGPVPKPGIRTPRVGNNPFSSAQPADRPIPRPPAPRPGTARPGVPRPGASPGSMPPRPGGAVGGARPPRPGAPRPGGRPGAPGAGRSDAGGGNYRGGGVGAAPGTGFRGRPGGGGGGRPGQRGGAAGAFGRPGGAPRRGRKSKRQKRQEYDSMQAPVVGGVRLPHGNGETIRLARGASLSDFADKIDANPAALVQALFNLGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLESFDLSYGEDEGGEEDLQVRPPVVTVMGHVDHGKTRLLDTIRKANVREAEAGGITQHIGAYQVAVDLDGSQRLITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEYGLVPEEFGGDTMFVDISAKQGTNIEALEEAVLLTADAALDLRANPDMEAQGVAIEAHLDRGRGPVATVLVQRGTLRVGDSVVAGDAYGRVRRMVDEHGEDVEVALPSRPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNALAARSRKRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIQVDDEVVLRVIDRGVGGITETNVNLASASDAVIIGFNVRAEGKATELASREGVEIRYYSVIYQAIDEIEQALRGLLKPIYEENQLGRAEIRALFRSSKVGLIAGCLVTSGVMRRNAKARLLRDNIVVAENLSIASLRREKDDVTEVRDGFECGLTLGYADIKEGDVIESYELVQKERA
Mass: 94,041 Da
Length: 900 Aa

Rv2839c doesn't seem to be a targeted by any drug.

Rv2839c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.