Gene - combatTB X

Rv2850c

Type: protein_coding
Name: Rv2850c
Locus Name: Rv2850c
Product: Possible magnesium chelatase
Functional Category: Intermediary metabolism and respiration
Location: 3158165..3160054 (- strand)
Gene Length: 1889 bp
Nucleotides: GTGAAGCCTTATCCGTTCAGCGCGATCGTCGGGCACGATCGGCTGCGGCTCGCGTTGTTGTTGTGTGCCGTGCGACCGGAGATCGGTGGGGCGCTCATCCGTGGCGAGAAGGGCACGGCGAAATCGACGGCGGTGCGCGGGCTGGCCGCGTTGTTGTCGGTCGCGACCGGGAGCACCGAGACCGGCCTCGTGGAGCTGCCGCTGGGGGCCACCGAAGACCGGGTGGTTGGCTCGCTGGATCTGCAGCGGGTGATGCGCGACGGCGAGCACGCGTTCTCTCCGGGACTGCTGGCTCGCGCCCACGGCGGCGTGCTCTACGTCGACGAGGTCAATCTGCTGCATGATCACCTGGTTGACATCCTGCTCGACGCCGCCGCCATGGGACGCGTACACGTCGAACGCGACGGCATCTCCCATTCCCACGAGGCCCGTTTCGTGCTGATCGGCACGATGAATCCGGAGGAGGGCGAACTGCGTCCGCAGCTGCTGGACCGGTTCGGGCTGACCGTCGACGTGCAGGCGTCACGTGACATCGACGTGCGGGTACAGGTCATCCGCCGGCGGATGGCCTACGAAGCCGACCCGGATGCGTTCGTCGCACGCTATGCCGACGCCGACGCGGAGCTGGCCCACCGGATTGCCGCGGCCCGGGCCACGGTAGACGATGTGGTGTTGGGCGACAACGAGTTGCGGCGCATCGCTGCGTTGTGCGCGGCGTTCGACGTGGACGGCATGCGGGCCGATCTGGTAGTGGCCCGGACCGCCGCCGCGCACGCCGCCTGGCGTGGTGTCCGCACCGTTGAGGAGCAGGATATCCGGGCGGCAGCAGAACTGGCGTTGCCGCATCGTCGTCGTCGCGACCCGTTCGACGATCACGGCATCGACCGCGACCAGCTGGATGAGGCGCTGGCGCTGGCGAGCGTCGACCCAGAGCCCGAGCCCGATCCGCCCGGGGGCGGCCAGTCAGCCAATGAACCTGCCTCACAACCGAACTCACGCTCGAAGTCGACAGAACCTGGTGCGCCGAGCTCGATGGGCGACGACCCGCCGCGCCCGGCTTCGCCGCGCTTGCGATCGTCGCCGCGCCCGAGCGCGCCGCCGTCAAAGATATTCCGGACCCGCGCGCTGCGGGTCCCGGGGGTCGGCACGGGCGCGCCGGGGCGACGGTCTCGGGCCCGCAACGCCTCGGGCAGTGTGGTGGCGGCCGCCGAGGTCAGCGACCCCGACGCACATGGACTGCACCTGTTCGCTACCCTGCTGGCCGCCGGCGAGCGTGCGTTCGGAGCCGGGCCGTTGCGCCCGTGGCCGGACGATGTGCGCCGGGCCATCCGCGAGGGTCGCGAAGGCAATCTGGTGATCTTCGTCGTCGACGCTTCCGGATCGATGGCTGCTCGGGACCGGATGGCTGCGGTCAGTGGCGCCACCCTGTCGCTGCTGCGCGACGCCTACCAGCGCAGGGACAAGGTGGCGGTGATCACCTTCCGCCAGCACGAGGCAACGCTGTTGCTGTCGCCGACGTCGTCGGCGCACATCGCCGGCCGGCGACTGGCCCGATTCAGCACCGGCGGCAAGACCCCGCTGGCTGAGGGACTGCTGGCCGCGCGTGCGCTGATCATCCGGGAGAAGGTACGCGACCGCGCCCGACGCCCCCTGGTGGTCGTGCTGACCGACGGCCGGGCCACCGCCGGGCCGGACCCGTTGGGCCGCAGCCGAACCGCGGCTGCCGGGCTGGTCGCCGAGGGCGCGGCCGCGGTGGTGGTGGACTGCGAAACGTCGTATGTACGGCTGGGTTTGGCAGCGCAACTGGCTCGTCAGCTGGGTGCGCCGGTGGTTCGGTTGGAGCAGTTGCACGCGGATTATCTAGTGCATGCCGTGCGTGGCGTGGCTTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Mg-chelatase subunits D/I family

GO

ATP binding GO:0005524 molecular_function
ATPase activity GO:0016887 molecular_function

InterPro

UniProt: P9WPR3
GenBank: Rv2850c
EnsemblBacteria: Rv2850c
Mycobrowser: Rv2850c

Summary

Name: Uncharacterized protein Rv2850c
Family: Mg-chelatase subunits D/I family
Protein Sequence: MKPYPFSAIVGHDRLRLALLLCAVRPEIGGALIRGEKGTAKSTAVRGLAALLSVATGSTETGLVELPLGATEDRVVGSLDLQRVMRDGEHAFSPGLLARAHGGVLYVDEVNLLHDHLVDILLDAAAMGRVHVERDGISHSHEARFVLIGTMNPEEGELRPQLLDRFGLTVDVQASRDIDVRVQVIRRRMAYEADPDAFVARYADADAELAHRIAAARATVDDVVLGDNELRRIAALCAAFDVDGMRADLVVARTAAAHAAWRGVRTVEEQDIRAAAELALPHRRRRDPFDDHGIDRDQLDEALALASVDPEPEPDPPGGGQSANEPASQPNSRSKSTEPGAPSSMGDDPPRPASPRLRSSPRPSAPPSKIFRTRALRVPGVGTGAPGRRSRARNASGSVVAAAEVSDPDAHGLHLFATLLAAGERAFGAGPLRPWPDDVRRAIREGREGNLVIFVVDASGSMAARDRMAAVSGATLSLLRDAYQRRDKVAVITFRQHEATLLLSPTSSAHIAGRRLARFSTGGKTPLAEGLLAARALIIREKVRDRARRPLVVVLTDGRATAGPDPLGRSRTAAAGLVAEGAAAVVVDCETSYVRLGLAAQLARQLGAPVVRLEQLHADYLVHAVRGVA
Mass: 66,987 Da
Length: 629 Aa

Rv2850c doesn't seem to be a targeted by any drug.

Porphyrin and chlorophyll metabolism mtu00860
mtu00860
PATHWAY_MAP mtu00860 Porphyrin and chlorophyll metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.