Gene - combatTB X

frr

Type: protein_coding
Name: frr
Locus Name: Rv2882c
Product: Ribosome recycling factor Frr (ribosome releasing factor) (RRF)
Functional Category: Information pathways
Location: 3191644..3192201 (- strand)
Gene Length: 557 bp
Nucleotides: ATGATTGATGAGGCTCTCTTCGACGCCGAAGAGAAAATGGAGAAGGCTGTGGCGGTGGCACGTGACGACCTGTCAACTATCCGTACCGGCCGCGCCAACCCTGGCATGTTCTCTCGGATCACCATCGACTACTACGGTGCGGCCACCCCGATCACGCAACTGGCCAGCATCAATGTCCCCGAGGCGCGGCTAGTCGTGATAAAGCCGTATGAAGCCAATCAGTTGCGCGCTATCGAGACTGCAATTCGCAACTCCGACCTTGGAGTGAATCCCACCAACGACGGCGCCCTTATTCGCGTGGCCGTACCGCAGCTCACCGAAGAACGTCGGCGAGAGCTGGTCAAACAGGCAAAGCATAAGGGGGAGGAGGCCAAGGTTTCGGTGCGTAATATCCGTCGCAAAGCGATGGAGGAACTCCATCGCATCCGTAAGGAAGGCGAGGCCGGCGAGGATGAGGTCGGTCGCGCAGAAAAGGATCTCGACAAGACCACGCACCAATACGTCACCCAAATTGATGAGCTGGTTAAACACAAAGAAGGCGAGCTGCTGGAGGTCTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. {ECO:0000255|HAMAP-Rule:MF_00040}.

Family

RRF family

GO

ribosomal large subunit binding GO:0043023 molecular_function
cell wall GO:0005618 cellular_component
cytosol GO:0005829 cellular_component
cytoplasmic translational termination GO:0002184 biological_process
translation GO:0006412 biological_process
translational termination GO:0006415 biological_process
translation termination factor activity GO:0008079 molecular_function
cytoplasm GO:0005737 cellular_component
plasma membrane GO:0005886 cellular_component

InterPro

UniProt: P9WGY1
GenBank: Rv2882c
EnsemblBacteria: Rv2882c
Mycobrowser: Rv2882c

PDB IDs:

Summary

Name: Ribosome-recycling factor (RRF) (Ribosome-releasing factor)
Family: RRF family
Protein Sequence: MIDEALFDAEEKMEKAVAVARDDLSTIRTGRANPGMFSRITIDYYGAATPITQLASINVPEARLVVIKPYEANQLRAIETAIRNSDLGVNPTNDGALIRVAVPQLTEERRRELVKQAKHKGEEAKVSVRNIRRKAMEELHRIRKEGEAGEDEVGRAEKDLDKTTHQYVTQIDELVKHKEGELLEV
Mass: 20,828 Da
Length: 185 Aa

Rv2882c doesn't seem to be a targeted by any drug.

Rv2882c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.