Gene - combatTB X

fdhD

Type: protein_coding
Name: fdhD
Locus Name: Rv2899c
Product: Possible FdhD protein homolog
Functional Category: Intermediary metabolism and respiration
Location: 3208576..3209406 (- strand)
Gene Length: 830 bp
Nucleotides: GTGGGGTACGCAACGGCGCATCGGCGGGTCAGGCATCTCAGCGCCGATCAGGTGATCACCCGGCCGGAAACCTTGGCCGTCGAGGAGCCGCTGGAGATCCGCGTCAATGGGACGCCGGTTACCGTGACCATGCGCACGCCAGGATCGGATTTCGAACTGGTGCAAGGCTTTCTGCTTGCCGAAGGGGTGGTTGCGCACCGCGAAGACGTGCTGACCGTTAGCTACTGTGGCAGGCGCGTCGAGGGCAATGCCACAGGGGCCAGCACGTACAACGTTTTGGATGTGGCTCTGGCGCCCGGCGTCAAGCCGCCCGATGTCGATGTCACCCGCACCTTCTACACCACCTCGTCGTGCGGAGTCTGTGGTAAGGCGTCGCTTCAGGCGGTGAGCCAGGTCAGCCGATTCGCACCGGGCGGCGATCCCGCTACCGTCGCCGCCGACACTCTCAAGGCGATGCCGGACCAACTTCGGCGCGCGCAAAAGGTTTTCGCGAGAACCGGTGGGCTGCACGCTGCGGCACTATTCGGGGTGGACGGCGCCATGCTTGCCGTGCGTGAGGATATCGGCCGGCACAATGCGGTCGACAAGGTCATCGGCTGGGCTTTCGAGCGTGACCGAATACCGCTTGGCGCCTCGGTGTTGTTGGTCAGCGGGCGGGCGTCGTTCGAGTTGACCCAAAAGGCGCTGATGGCTGGGATTCCGGTGCTGGCCGCGGTATCCGCGCCGTCGTCGCTGGCGGTTTCGTTGGCCGACGCGTCCGGGATCACGCTGGTGGCTTTCCTGCGGGGGGACTCGATGAACGTCTACACCAGAGCGGACCGAATCACCTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. {ECO:0000255|HAMAP-Rule:MF_00187}.

Family

FdhD family

GO

sulfur carrier activity GO:0097163 molecular_function
cytoplasm GO:0005737 cellular_component
sulfurtransferase activity GO:0016783 molecular_function
Mo-molybdopterin cofactor biosynthetic process GO:0006777 biological_process

InterPro

UniProt: P9WNF1
GenBank: Rv2899c
EnsemblBacteria: Rv2899c
Mycobrowser: Rv2899c

Summary

Name: Sulfur carrier protein FdhD
Family: FdhD family
Protein Sequence: MGYATAHRRVRHLSADQVITRPETLAVEEPLEIRVNGTPVTVTMRTPGSDFELVQGFLLAEGVVAHREDVLTVSYCGRRVEGNATGASTYNVLDVALAPGVKPPDVDVTRTFYTTSSCGVCGKASLQAVSQVSRFAPGGDPATVAADTLKAMPDQLRRAQKVFARTGGLHAAALFGVDGAMLAVREDIGRHNAVDKVIGWAFERDRIPLGASVLLVSGRASFELTQKALMAGIPVLAAVSAPSSLAVSLADASGITLVAFLRGDSMNVYTRADRIT
Mass: 29,090 Da
Length: 276 Aa

Rv2899c doesn't seem to be a targeted by any drug.

Rv2899c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.