lepB
- Type
- protein_coding
- Name
- lepB
- Locus Name
-
Rv2903c
- Product
-
Probable signal peptidase I LepB (SPASE I) (leader peptidase I).
- Functional Category
-
Cell wall and cell processes
- Location
- 3212970..3213854 (- strand)
- Gene Length
- 884 bp
- Nucleotides
-
GTGACCGAAACCACGGACTCCCCATCGGAGCGCCAGCCGGGTCCGGCAGAGCCGGAGCTCTCCTCCCGGGACCCGGACATTGCCGGCCAGGTCTTCGACGCAGCCCCGTTCGACGCAGCCCCGGATGCGGACTCCGAAGGCGACTCCAAGGCGGCCAAAACGGACGAGCCGCGGCCCGCGAAGCGATCAACGCTGCGGGAGTTCGCGGTGCTGGCGGTGATTGCTGTGGTGCTCTACTACGTCATGCTGACGTTTGTCGCGCGCCCTTATCTGATTCCGTCGGAATCGATGGAACCCACGTTGCACGGGTGTTCGACGTGCGTCGGCGACCGCATCATGGTGGACAAACTCAGCTACCGCTTCGGCTCACCGCAACCTGGCGACGTCATCGTCTTCAGGGGACCGCCGTCGTGGAACGTTGGTTACAAGTCGATCCGTTCGCACAACGTCGCCGTGCGCTGGGTGCAGAACGCGTTGTCGTTCATCGGTTTCGTGCCTCCCGACGAGAACGACCTGGTCAAGCGTGTCATCGCGGTCGGCGGACAGACGGTTCAATGCCGGTCCGACACCGGCCTGACGGTCAACGGCAGGCCACTGAAGGAGCCATACCTGGATCCGGCCACCATGATGGCCGACCCGTCGATATACCCGTGCCTGGGCAGCGAGTTCGGGCCGGTCACCGTCCCGCCCGGGCGTGTCTGGGTGATGGGCGACAACCGCACCCATTCGGCGGATTCCCGCGCTCACTGCCCGTTGCTATGTACTGACGATCCGCTACCGGGGACCGTGCCGGTGGCCAACGTCATCGGTAAGGCCAGGTTGATCGTGTGGCCGCCGTCGCGTTGGGGTGTTGTGCGTTCGGTGAATCCCCAGCAAGGTCGGTA
- Drug Resistance
- Mutations
- Function
- Unknown
- Family
-
Peptidase S26 family
- GO
-
- serine-type endopeptidase activity GO:0004252 molecular_function
- signal peptide processing GO:0006465 biological_process
- integral component of plasma membrane GO:0005887 cellular_component
- extracellular region GO:0005576 cellular_component
- InterPro
Summary
- Name
- Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I)
- Family
- Peptidase S26 family
- Protein Sequence
-
MTETTDSPSERQPGPAEPELSSRDPDIAGQVFDAAPFDAAPDADSEGDSKAAKTDEPRPAKRSTLREFAVLAVIAVVLYYVMLTFVARPYLIPSESMEPTLHGCSTCVGDRIMVDKLSYRFGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALSFIGFVPPDENDLVKRVIAVGGQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPCLGSEFGPVTVPPGRVWVMGDNRTHSADSRAHCPLLCTDDPLPGTVPVANVIGKARLIVWPPSRWGVVRSVNPQQGR
- Mass
- 31,880 Da
- Length
- 294 Aa
Rv2903c doesn't seem to be a targeted by any drug.
-
-
Protein export mtu03060
mtu03060Genetic Information Processing; Folding, sorting and degradation
-
- Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions.
- J Bacteriol. 2012 May;194(10):2614-9. doi: 10.1128/JB.00224-12. Epub 2012 Mar 16.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.