Gene - combatTB X

Rv2913c

Type: protein_coding
Name: Rv2913c
Locus Name: Rv2913c
Product: Possible D-amino acid aminohydrolase (D-amino acid hydrolase)
Functional Category: Intermediary metabolism and respiration
Location: 3219863..3221698 (- strand)
Gene Length: 1835 bp
Nucleotides: ATGTTAGCTTGGCGGCAACTCAACGATCTGGAGGAAACGGTGACCTACGACGTGATCATTCGCGACGGACTGTGGTTCGACGGCACCGGCAATGCGCCATTGACTCGCACTCTGGGCATTCGCGACGGCGTGGTGGCCACGGTGGCTGCCGGCGCACTGGACGAGACCGGCTGCCCGGAGGTGGTTGATGCGGCGGGGAAGTGGGTCGTGCCTGGCTTCATCGACGTGCACACCCACTATGACGCCGAGGTGTTGCTCGATCCTGGTTTGCGGGAGTCGGTGCGCCACGGTGTCACCACGGTGCTGCTGGGAAACTGCTCGTTGTCGACGGTCTACGCCAACTCCGAGGATGCCGCCGACCTGTTCAGCCGTGTTGAAGCGGTGCCCCGCGAATTTGTCCTGGGTGCCCTGCGGGACAACCAGACGTGGTCGACGCCCGCGGAGTACATCGAAGCGATCGACGCCCTGCCCCTCGGGCCGAATGTGAGTTCACTGCTTGGCCATTCGGATCTGCGGACCGCGGTACTGGGCCTTGATCGTGCCACCGACGACACCGTCCGGCCCACCGAAGCCGAGCTGGCGAAGATGGCGAAACTGCTCGATGAGGCGCTCGAGGCCGGGATGCTGGGCATGTCCGGGATGGACGCCGCTATCGACAAGCTCGACGGCGACCGCTTCCGCTCGCGTGCGCTGCCGTCCACCTTCGCGACCTGGCGGGAGCGTCGCAAGCTGATCTCGGTGCTGCGCCACCGGGGCCGGATACTGCAGAGCGCACCCGACGTCGACAACCCGGTGTCCGCGCTGCTGTTTTTCTTGGCCAGCAGCCGGATATTCAACCGGCGCAAGGGCGTTCGAATGAGCATGTTGGTGTCCGCCGACGCCAAGTCGATGCCGCTGGCGGTACACGTGTTCGGGTTGGGCACCCGCGTGCTGAACAAGCTCTTAGGCTCTCAGGTGCGATTCCAGCATCTGCCGGTCCCGTTCGAGCTGTACTCCGACGGCATCGACCTGCCGGTCTTCGAGGAGTTCGGCGCCGGAACGGCGGCCCTTCATCTGCGTGACCAACTGCAGCGCAACGAGCTCCTGGCCGACAGGTCTTACCGCCGGTCGTTCCGGCGCGAGTTCGATCGCATCAAGCTCGGACCTTCGTTGTGGCATCGGGACTTCCACGACGCCGTGATCGTCGAATGCCCGGATAAGTCGTTGATCGGTAAGAGTTTCGGGGCAATAGCCGACGAGCGCGGGCTGCACCCGCTGGACGCGTTCCTCGATGTGCTGGTGGACAACGGGGAGCGCAATGTCCGATGGACCACCATCGTCGCCAATCACCGGCCCAACCAGCTGAACAAGCTGGCCGCCGAACCGAGTGTCCACATGGGCTTCTCCGACGCCGGCGCGCACCTGCGCAATATGGCGTTCTACAACTTCGGGCTTCGGCTGCTCAAACGAGCCAGAGACGCCGACCGGGCCGGACAACCGTTTCTGTCCATCGAGCGGGCAGTGTATCGCCTCACCGGTGAGTTGGCCGAGTGGTTCGGTATAGGCGCGGGCACGTTGCGCCAGGGTGACCGTGCGGACTTCGCGGTGATTGACCCTACCCACCTAGATGAATCGGTGGACGGGTACCACGAGGAGGCGGTGCCCTACTATGGCGGTCTGCGACGCATGGTCAACCGCAACGATGCGACCGTGGTTGCGACGGGCGTGGGCGGCACCGTGGTATTCCGCGGAGGCCAGTTCGGAGGTCAGTTCCGCGACGGCTACGGGCAGAACGTGAAGTCGGGTCGCTACCTGCGGGCGGGTGAGCTCGGCGCCGCTCTGAGCCGTTCTGCCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Metallo-dependent hydrolases superfamily, N-acyl-D-amino-acid deacylase family

GO

cytosol GO:0005829 cellular_component
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0016812 molecular_function

InterPro

UniProt: P9WJH9
GenBank: Rv2913c
EnsemblBacteria: Rv2913c
Mycobrowser: Rv2913c

Summary

Name: Uncharacterized protein Rv2913c
Family: Metallo-dependent hydrolases superfamily, N-acyl-D-amino-acid deacylase family
Protein Sequence: MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVVATVAAGALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTTVLLGNCSLSTVYANSEDAADLFSRVEAVPREFVLGALRDNQTWSTPAEYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMAKLLDEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRKLISVLRHRGRILQSAPDVDNPVSALLFFLASSRIFNRRKGVRMSMLVSADAKSMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSDGIDLPVFEEFGAGTAALHLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFHDAVIVECPDKSLIGKSFGAIADERGLHPLDAFLDVLVDNGERNVRWTTIVANHRPNQLNKLAAEPSVHMGFSDAGAHLRNMAFYNFGLRLLKRARDADRAGQPFLSIERAVYRLTGELAEWFGIGAGTLRQGDRADFAVIDPTHLDESVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFRGGQFGGQFRDGYGQNVKSGRYLRAGELGAALSRSA
Mass: 67,205 Da
Length: 611 Aa

Rv2913c doesn't seem to be a targeted by any drug.

Rv2913c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.