pknI
- Type
- protein_coding
- Name
- pknI
- Locus Name
-
Rv2914c
- Product
-
Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydroxyalkyl-protein kinase)
- Functional Category
-
Regulatory proteins
- Location
- 3221767..3223524 (- strand)
- Gene Length
- 1757 bp
- Nucleotides
-
ATGGCGTTGGCCAGCGGCGTGACCTTTGCCGGCTACACCGTCGTGCGGATGCTGGGTTGTTCCGCGATGGGTGAGGTCTACCTCGTGCAACATCCCGGATTCCCCGGCTGGCAGGCGCTGAAGGTGCTTTCGCCGGCGATGGCTGCGGACGACGAATTTCGCCGCCGATTTCAACGGGAGACCGAGGTTGCCGCGCGGCTATTTCACCCGCACATCCTGGAGGTTCATGATCGCGGTGAGTTCGACGGGCAGCTGTGGATTGCGATGGACTACGTCGATGGCATCGACGCCACGCAGCATATGGCCGACCGGTTTCCGGCGGTCTTGCCGGTTGGTGAGGTACTCGCCATCGTCACTGCCGTAGCCGGAGCTCTCGACTACGCCCACCAGCGCGGCCTGCTGCATCGTGACGTCAACCCCGCCAACGTCGTGCTAACCAGTCAGAGTGCTGGCGACCAACGGATCCTGTTGGCCGACTTCGGAATTGCCAGCCAACCCAGCTATCCGGCGCCCGAACTGTCGGCGGGGGCCGACGTTGACGGGCGTGCCGATCAGTACGCGTTGGCGCTTACCGCCATACACCTGTTCGCCGGTGCGCCGCCGGTTGATCGTTCGCACACCGGACCGCTGCAGCCACCGAAGCTCTCCGCCTTCCGCCCGGACCTGGCACGCCTCGACGGTGTCCTCTCGCGTGCGCTCGCCACAGCGCCCGCGGACCGGTTCGGCAGCTGCCGCGAGTTCGCCGACGCGATGAACGAACAGGCCGGCGTCGCGATCGCTGATCAGAGCTCGGGGGGTGTCGACGCTTCTGAGGTCACCGCGGCGGCCGGTGAGGAAGCGTATGTCGTCGACTACCCGGCTTATGGTTGGCCCGAGGCCGTCGACTGCAAAGAACCATCCGCCCGGGCACCGGCGCCGGCGGCCCCGACCCCCCAACGGCGCGGCTCGATGCTGCAGTCAGCGGCCGGGGTGCTGGCGCGCCGCCTGGACAACTTCTCCACCGCCACCAAGGCTCCGGCGAGCCCCACCAGGCGCCGGCCACGCCGGATCCTGGTCGGTGCGGTAGCGGTGTTGCTATTGGCTGGCCTGTTCGCGGTCGGCATCGTGATTGGGCGCAAGACGAACACGACCGCCACCGAAGTCGCGCGCCCGCCGACCAGTGGGTCGGCTGTGCCCAGCGCCCCGACGACCACCGTCGCGGTCACCGCGCCGGTCCCACTGGACGGCACATACCGCATCGAGATCCAACGCTCAAAGCAGACCTACGACTACACCCCTACGCCGCAACCGCCGGACGTGAACACCTGGTGGGCGTTCCGCACTTCGTGCACTCCGACCGAATGTCTCGCGGCCGCAACGATGCTCGACGACAACGACCACACCCAGGCCAAGACTCCGCCCGTTAGGCCGTTCCTCATGCAGTTCGGCGAGGGCCAGTGGAAGTCGCGGCCGGAGACGGTGCAGTTCCCGTGCGTCGGGCCCAACGGCTCGCCGAGTACACAGGCCACGACGCAGTTGCTCGCACTGCGACCGCAACCGCAGGGCGACCTCGTCGGCGAAATGGTCGTCACTGTGCATAGCAACGAATGTGGACAACAAGGAGCGGTCATTCGGATTCCCGCGGTGGCCAGCCGCAGTGGTGATCTTCCCCCGGCAGTCACCGTGCCGGACCCAGCAACGATTCCTGATACCCCCGATACAACGTCCACAGCCACCCTGACGCCGCCGACCACAACGGCGCCGGGGCCCGGTCGCTG
- Drug Resistance
- Mutations
- Function
- Plays an important role in slowing down the growth of mycobacteria within the infected host. {ECO:0000269|PubMed:19341393}.
- Family
-
Protein kinase superfamily, Ser/Thr protein kinase family
- GO
-
- protein autophosphorylation GO:0046777 biological_process
- pathogenesis GO:0009405 biological_process
- peptidyl-threonine phosphorylation GO:0018107 biological_process
- peptidyl-serine phosphorylation GO:0018105 biological_process
- manganese ion binding GO:0030145 molecular_function
- regulation of growth rate GO:0040009 biological_process
- ATP binding GO:0005524 molecular_function
- cytosol GO:0005829 cellular_component
- plasma membrane GO:0005886 cellular_component
- protein serine/threonine kinase activity GO:0004674 molecular_function
- protein kinase activity GO:0004672 molecular_function
- integral component of membrane GO:0016021 cellular_component
- InterPro
5M06
- Name
- Serine/threonine-protein kinase PknI (EC 2.7.11.1)
- Family
- Protein kinase superfamily, Ser/Thr protein kinase family
- Protein Sequence
-
MALASGVTFAGYTVVRMLGCSAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFRPDLARLDGVLSRALATAPADRFGSCREFADAMNEQAGVAIADQSSGGVDASEVTAAAGEEAYVVDYPAYGWPEAVDCKEPSARAPAPAAPTPQRRGSMLQSAAGVLARRLDNFSTATKAPASPTRRRPRRILVGAVAVLLLAGLFAVGIVIGRKTNTTATEVARPPTSGSAVPSAPTTTVAVTAPVPLDGTYRIEIQRSKQTYDYTPTPQPPDVNTWWAFRTSCTPTECLAAATMLDDNDHTQAKTPPVRPFLMQFGEGQWKSRPETVQFPCVGPNGSPSTQATTQLLALRPQPQGDLVGEMVVTVHSNECGQQGAVIRIPAVASRSGDLPPAVTVPDPATIPDTPDTTSTATLTPPTTTAPGPGR
- Mass
- 61,805 Da
- Length
- 585 Aa
Summary
Rv2914c doesn't seem to be a targeted by any drug.
Rv2914c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection.
- FEMS Microbiol Lett. 2009 Jun;295(1):23-9. doi: 10.1111/j.1574-6968.2009.01570.x. Epub 2009 Apr 1.
- Protein kinase I of Mycobacterium tuberculosis: cellular localization and expression during infection of macrophage-like cells.
- Tuberculosis (Edinb). 2006 Jan;86(1):28-33. doi: 10.1016/j.tube.2005.04.002. Epub 2005 Oct 26.
- Cloning, overexpression, and characterization of a serine/threonine protein kinase pknI from Mycobacterium tuberculosis H37Rv.
- Protein Expr Purif. 2004 Jul;36(1):82-9. doi: 10.1016/j.pep.2004.03.011.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.