Gene - combatTB X

ffh

Type: protein_coding
Name: ffh
Locus Name: Rv2916c
Product: Probable signal recognition particle protein Ffh (fifty-four homolog) (SRP protein)
Functional Category: Cell wall and cell processes
Location: 3224708..3226285 (- strand)
Gene Length: 1577 bp
Nucleotides: GTGTTTGAATCGCTGTCTGACCGTTTGACCGCCGCCCTGCAGGGGCTGCGCGGCAAGGGCCGACTGACCGATGCCGATATCGATGCCACTACCCGCGAAATTCGTTTGGCGCTGCTGGAAGCCGATGTTTCGCTACCGGTGGTCCGGGCATTCATCCACCGGATCAAAGAACGCGCCCGCGGGGCCGAGGTGTCAAGTGCCCTCAACCCGGCTCAACAGGTCGTCAAGATCGTCAACGAGGAACTGATAAGCATCCTCGGCGGCGAAACCCGCGAGTTGGCGTTTGCGAAGACCCCGCCGACCGTCGTGATGCTCGCCGGCCTGCAGGGCTCCGGGAAGACGACACTGGCCGGCAAATTGGCCGCCCGCCTGCGTGGACAAGGACACACGCCACTGCTGGTCGCTTGTGACCTGCAACGGCCGGCCGCGGTGAACCAGCTGCAGGTCGTCGGCGAGCGTGCCGGAGTGCCGGTGTTCGCGCCGCATCCGGGTGCCTCGCCGGAGTCCGGCCCCGGTGACCCGGTTGCGGTGGCGGCGGCCGGGCTGGCCGAGGCCCGGGCCAAGCACTTCGACGTCGTCATCGTCGACACCGCCGGACGACTGGGCATCGACGAGGAGCTGATGGCCCAGGCCGCGGCCATCCGCGACGCCATCAACCCCGACGAGGTGCTGTTCGTCCTGGACGCGATGATCGGCCAGGACGCGGTCACCACCGCTGCGGCGTTCGGCGAGGGCGTCGGGTTCACCGGTGTGGCCTTGACCAAGCTCGACGGTGACGCCCGCGGTGGTGCCGCGTTATCGGTGCGCGAAGTGACCGGTGTTCCAATCCTTTTCGCCTCCACCGGGGAGAAGCTGGAGGACTTCGACGTCTTCCACCCGGACCGGATGGCCAGTCGCATCTTGGGCATGGGCGATGTGCTGAGCCTGATCGAACAGGCCGAGCAGGTCTTCGATGCACAACAGGCCGAGGAGGCCGCAGCCAAGATCGGCGCCGGCGAGCTGACCCTGGAGGACTTCCTCGAGCAGATGCTCGCGGTACGCAAGATGGGCCCGATCGGCAACCTGCTGGGCATGCTGCCCGGCGCGGCTCAGATGAAGGACGCGTTGGCCGAGGTCGACGACAAACAACTCGATCGTGTCCAGGCCATCATTCGCGGCATGACGCCGCAGGAACGGGCAGACCCCAAGATCATCAATGCCTCGCGGCGGCTGCGCATCGCCAACGGCTCGGGCGTCACGGTGTCCGAGGTCAACCAGCTGGTCGAGCGCTTCTTCGAAGCCCGCAAGATGATGTCGTCCATGCTCGGGGGCATGGGCATACCGGGCATAGGGCGCAAATCCGCGACGCGAAAGAGCAAGGGCGCAAAAGGCAAATCCGGCAAGAAGAGTAAGAAGGGGACGCGCGGTCCGACGCCGCCGAAGGTCAAGAGCCCGTTCGGCGTGCCCGGGATGCCGGGCTTGGCTGGGCTACCTGGGGGGCTCCCTGATCTCTCACAGATGCCCAAAGGTCTCGACGAGCTGCCGCCCGGCCTGGCCGACTTCGACCTGTCCAAGCTGAAGTTCCCAGGCAAGAAGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity). Shows GTPase activity. {ECO:0000255|HAMAP-Rule:MF_00306, ECO:0000269|PubMed:22534010}.

Family

GTP-binding SRP family, SRP54 subfamily

GO

signal recognition particle GO:0048500 cellular_component
GTPase activity GO:0003924 molecular_function
cell wall GO:0005618 cellular_component
GTP binding GO:0005525 molecular_function
plasma membrane GO:0005886 cellular_component
7S RNA binding GO:0008312 molecular_function
SRP-dependent cotranslational protein targeting to membrane GO:0006614 biological_process

InterPro

UniProt: P9WGD7
GenBank: Rv2916c
EnsemblBacteria: Rv2916c
Mycobrowser: Rv2916c

Summary

Name: Signal recognition particle protein (Fifty-four homolog)
Family: GTP-binding SRP family, SRP54 subfamily
Protein Sequence: MFESLSDRLTAALQGLRGKGRLTDADIDATTREIRLALLEADVSLPVVRAFIHRIKERARGAEVSSALNPAQQVVKIVNEELISILGGETRELAFAKTPPTVVMLAGLQGSGKTTLAGKLAARLRGQGHTPLLVACDLQRPAAVNQLQVVGERAGVPVFAPHPGASPESGPGDPVAVAAAGLAEARAKHFDVVIVDTAGRLGIDEELMAQAAAIRDAINPDEVLFVLDAMIGQDAVTTAAAFGEGVGFTGVALTKLDGDARGGAALSVREVTGVPILFASTGEKLEDFDVFHPDRMASRILGMGDVLSLIEQAEQVFDAQQAEEAAAKIGAGELTLEDFLEQMLAVRKMGPIGNLLGMLPGAAQMKDALAEVDDKQLDRVQAIIRGMTPQERADPKIINASRRLRIANGSGVTVSEVNQLVERFFEARKMMSSMLGGMGIPGIGRKSATRKSKGAKGKSGKKSKKGTRGPTPPKVKSPFGVPGMPGLAGLPGGLPDLSQMPKGLDELPPGLADFDLSKLKFPGKK
Mass: 55,002 Da
Length: 525 Aa

Rv2916c doesn't seem to be a targeted by any drug.

Bacterial secretion system mtu03070
mtu03070
Environmental Information Processing; Membrane transport

Protein export mtu03060
mtu03060
Genetic Information Processing; Folding, sorting and degradation

Quorum sensing mtu02024
mtu02024
Cellular Processes; Cellular community - prokaryotes

Characterization of Ffh of Mycobacterium tuberculosis and its interaction with 4.5S RNA.: Microbiol Res. 2012 Oct 12;167(9):520-5. doi: 10.1016/j.micres.2012.03.002. Epub 2012 Apr 24.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.