rnc
- Type
- protein_coding
- Name
- rnc
- Locus Name
-
Rv2925c
- Product
-
Probable ribonuclease III Rnc (RNase III)
- Functional Category
-
Information pathways
- Location
- 3239829..3240551 (- strand)
- Gene Length
- 722 bp
- Nucleotides
-
ATGATCCGGTCACGACAACCCCTGCTCGACGCACTCGGTGTGGACCTCCCGGACGAGCTGCTCTCACTGGCGTTGACCCACCGCAGCTACGCCTACGAGAACGGCGGGCTGCCGACCAACGAGCGTTTGGAGTTTCTCGGCGATGCCGTGCTAGGGCTGACCATCACCGACGCGCTGTTCCATCGTCATCCTGATCGGTCGGAGGGGGATCTGGCCAAACTGCGGGCCAGCGTAGTCAACACCCAGGCCCTGGCCGACGTCGCACGCCGCCTCTGTGCGGAAGGCCTCGGTGTTCACGTGCTATTGGGTCGCGGCGAGGCGAACACCGGCGGGGCCGACAAGTCCAGCATTCTGGCCGACGGTATGGAATCGCTGCTGGGCGCGATCTACCTGCAACACGGTATGGAGAAGGCCCGTGAGGTGATCCTGCGGCTGTTTGGCCCGTTGCTGGACGCCGCGCCGACCCTGGGTGCGGGATTGGATTGGAAGACCAGCTTGCAGGAGCTGACTGCAGCGCGAGGGCTGGGTGCGCCGTCATACCTGGTCACCTCCACCGGCCCGGACCACGATAAGGAATTCACCGCGGTGGTTGTCGTGATGGACAGCGAATACGGTTCAGGAGTGGGCCGGTCCAAAAAAGAAGCCGAGCAAAAAGCCGCGGCGGCCGCTTGGAAAGCCCTGGAAGTGCTCGACAACGCCATGCCGGGCAAAACCTCCGCCTA
- Drug Resistance
- Mutations
- Function
- Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism (By similarity). {ECO:0000250}.
- Family
-
Ribonuclease III family
- GO
-
- metal ion binding GO:0046872 molecular_function
- double-stranded RNA binding GO:0003725 molecular_function
- rRNA processing GO:0006364 biological_process
- cytoplasm GO:0005737 cellular_component
- ribonuclease III activity GO:0004525 molecular_function
- rRNA catabolic process GO:0016075 biological_process
- RNA processing GO:0006396 biological_process
- mRNA processing GO:0006397 biological_process
- tRNA processing GO:0008033 biological_process
- InterPro
2A11
- Name
- Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III)
- Family
- Ribonuclease III family
- Protein Sequence
-
MIRSRQPLLDALGVDLPDELLSLALTHRSYAYENGGLPTNERLEFLGDAVLGLTITDALFHRHPDRSEGDLAKLRASVVNTQALADVARRLCAEGLGVHVLLGRGEANTGGADKSSILADGMESLLGAIYLQHGMEKAREVILRLFGPLLDAAPTLGAGLDWKTSLQELTAARGLGAPSYLVTSTGPDHDKEFTAVVVVMDSEYGSGVGRSKKEAEQKAAAAAWKALEVLDNAMPGKTSA
- Mass
- 25,399 Da
- Length
- 240 Aa
Summary
Rv2925c doesn't seem to be a targeted by any drug.
Rv2925c doesn't seem to be involved in any pathway.
- Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A.
- Protein Sci. 2005 Oct;14(10):2744-50. doi: 10.1110/ps.051665905. Epub 2005 Sep 9.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.