Gene - combatTB X

ppsA

Type: protein_coding
Name: ppsA
Locus Name: Rv2931
Product: Phenolpthiocerol synthesis type-I polyketide synthase PpsA
Functional Category: Lipid metabolism
Location: 3245445..3251075 (+ strand)
Gene Length: 5630 bp
Nucleotides: TGACGGGAAGCATCAGTGGTGAAGCCGACCTTCGCCACTGGCTAATCGACTACCTAGTAACCAATATCGGCTGCACACCTGACGAGGTGGACCCCGATCTGTCGCTTGCCGACCTCGGCGTCAGCTCCCGCGACGCGGTCGTACTGTCCGGCGAACTGTCAGAGCTGCTGGGCAGGACCGTATCGCCGATTGACTTCTGGGAGCACCCGACGATCAACGCGCTGGCCGCGTATCTGGCCGCACCCGAGCCGAGCCCCGACTCCGACGCCGCAGTCAAGCGTGGTGCCCGGAACTCACTCGACGAGCCAATCGCCGTCGTCGGCATGGGATGTCGTTTCCCTGGCGGGATTTCGTGCCCAGAAGCATTGTGGGACTTTCTCTGTGAACGCCGTTCCTCGATCAGCCAGGTGCCGCCGCAACGATGGCAGCCCTTCGAAGGCGGGCCACCCGAGGTAGCCGCGGCGCTAGCGCGCACTACACGGTGGGGCTCATTTTTGCCCGACATCGACGCCTTCGACGCGGAATTCTTCGAGATCTCCCCCAGCGAAGCCGACAAGATGGACCCCCAGCAACGCCTGCTGCTGGAAGTGGCCTGGGAAGCGTTGGAGCACGCGGGAATCCCGCCCGGCACGCTGCGCCGCTCGGCAACAGGAGTGTTTGCCGGGGCATGCCTGAGCGAATACGGTGCGATGGCTTCCGCCGATCTGTCGCAGGTCGATGGTTGGAGCAATAGCGGTGGCGCGATGAGCATCATCGCCAACCGCCTCTCGTATTTCCTTGACCTGCGCGGCCCGTCGGTGGCGGTAGACACCGCATGCTCGTCGTCGTTGGTAGCGATCCACCTGGCCTGCCAGAGCCTTCGGACCCAGGACTGTCACCTGGCAATCGCAGCCGGCGTGAATTTGTTGTTGTCCCCGGCGGTATTTCGCGGTTTCGACCAAGTCGGCGCCTTGTCCCCGACAGGTCAGTGCCGTGCGTTCGATGCGACCGCCGACGGGTTTGTCCGCGGCGAGGGTGCCGGGGTAGTGGTGCTCAAGCGGTTGACCGATGCACAGCGCGACGGGGATCGGGTGCTTGCGGTGATCTGCGGTTCTGCGGTCAACCAGGACGGCCGATCCAACGGGCTGATGGCCCCCAACCCAGCGGCCCAGATGGCGGTGCTGCGTGCCGCCTACACCAACGCGGGGATGCAGCCCAGCGAGGTCGACTACGTCGAAGCGCACGGAACAGGGACGCTGTTGGGCGACCCGATCGAAGCCCGCGCTCTCGGAACGGTGCTGGGTCGCGGCCGGCCCGAGGATTCTCCGTTGCTCATCGGCTCTGTCAAGACCAACCTCGGTCACACCGAGGCTGCGGCTGGAATCGCGGGCTTCATCAAGACGGTGCTGGCTGTGCAGCATGGCCAGATTCCGCCAAATCAGCACTTCGAAACCGCGAACCCGCACATTCCCTTTACCGACTTGCGGATGAAAGTCGTTGACACACAAACTGAATGGCCGGCAACGGGCCATCCCCGCCGTGCCGGTGTGTCGTCGTTCGGCTTCGGTGGCACAAACGCGCACGTGGTGATCGAGCAGGGCCAGGAGGTGCGCCCCGCGCCTGGACAAGGCTTAAGTCCGGCGGTGTCGACCCTGGTAGTGGCCGGCAAGACTATGCAGCGGGTGTCCGCGACCGCGGGGATGCTAGCCGATTGGATGGAAGGGCCCGGCGCTGACGTGGCCTTGGCCGACGTGGCCCACACCCTCAATCACCACCGATCGCGGCAACCCAAGTTCGGCACGGTGGTGGCCCGTGACCGTACCCAGGCGATAGCCGGATTGCGTGCGCTGGCCGCCGGCCAACACGCCCCCGGCGTGGTCAACCCTGCCGACGGCTCGCCGGGGCCGGGCACCGTGTTCGTCTACTCCGGCCGCGGTTCACAGTGGGCTGGCATGGGCCGTCAATTGTTGGCCGACGAGCCGGCTTTCGCGGCCGCGGTCGCCGAATTGGAACCGGTGTTTGTCGAGCAAGCCGGCTTTTCGTTGCACGACGTGCTGGCTAACGGCGAGGAACTGGTCGGTATCGAGCAGATTCAGCTCGGGTTGATCGGGATGCAGCTGGCCCTGACCGAATTATGGTGTTCCTACGGGGTGCGGCCCGACCTGGTGATCGGCCACTCCATGGGCGAGGTGGCCGCCGCCGTGGTCGCCGGGGCACTGACCCCGGCCGAGGGTCTGCGGGTGACCGCCACCCGGTCACGGCTGATGGCACCGTTGTCCGGCCAGGGCGGCATGGCACTGCTGGAACTCGACGCGCCCACTACCGAGGCGTTGATTGCCGACTTCCCACAGGTGACGCTCGGTATTTACAACTCACCACGGCAAACGGTGATCGCCGGGCCCACCGAGCAGATCGATGAGTTGATCGCCCGGGTGCGCGCGCAAAACCGGTTTGCCAGTCGGGTCAATATCGAAGTGGCCCCGCACAATCCGGCCATGGATGCTTTGCAGCCGGCGATGCGTTCGGAGCTGGCCGATCTGACCCCACGGACCCCCACCATCGGAATCATCTCCACCACCTACGCAGACTTGCACACCCAACCGGTCTTCGACGCCGAACACTGGGCCACCAACATGCGCAACCCCGTGCGCTTCCAGCAGGCCATCGCTTCCGCCGGTAGCGGCGCCGACGGCGCCTACCACACCTTCATCGAAATCAGCGCACACCCGCTGCTGACCCAGGCCATCATCGACACTCTGCACAGCGCTCAACCCGGAGCCAGATACACCAGCCTCGGGACCCTGCAACGCGACACCGACGACGTCGTGACCTTCCGGACCAACCTCAACAAGGCCCACACCATCCACCCACCGCACACCCCCCACCCCCCCGAGCCACATCCGCCCATCCCCACCACCCCGTGGCAACACACCCGTCACTGGATCACCACCAAATATCCGGCCGGCTCTGTTGGATCGGCCCCCCGAGCGGGCACACTGCTCGGCCAACACACCACCGTCGCCACGGTCTCAGCGAGTCCGCCCTCCCACCTCTGGCAAGCAAGGCTGGCTCCGGACGCCAAGCCGTACCAGGGCGGTCATCGATTCCACCAAGTCGAGGTGGTCCCAGCTTCTGTTGTGCTGCACACAATCCTTTCCGCTGCAACAGAATTGGGCTACTCCGCGTTGTCCGAGGTCCGATTCGAGCAACCCATTTTCGCCGACCGGCCACGTCTAATCCAGGTCGTCGCCGACAACCGGGCGATCAGCCTGGCCTCGAGTCCGGCTGCCGGAACACCCTCAGACCGGTGGACGCGGCATGTTACCGCACAACTTTCCTCGTCACCGTCGGATTCGGCCAGCAGCTTGAACGAGCACCATCGCGCCAACGGGCAGCCGCCCGAACGTGCTCACCGCGACCTGATTCCCGACCTGGCCGAGCTGCTCGCAATGCGCGGCATCGATGGCCTGCCTTTCTCATGGACCGTCGCGTCGTGGACACAGCACTCGAGCAACCTCACGGTTGCGATCGATCTCCCCGAAGCTCTGCCCGAAGGGTCGACTGGGCCGCTCCTTGACGCCGCGGTGCACCTCGCCGCGCTATCGGACGTCGCTGATTCGCGGCTCTACGTGCCGGCAAGCATCGAGCAGATATCGCTCGGCGATGTCGTCACCGGGCCGCGTAGCTCGGTGACGCTGAACCGCACCGCTCACGACGACGACGGGATCACCGTCGATGTCACCGTTGCAGCCCACGGCGAAGTGCCGTCCCTGTCGATGAGGTCGCTTCGATACCGGGCTCTGGACTTTGGCCTAGACGTTGGTAGGGCGCAACCGCCCGCGTCGACCGGTCCGGTCGAGGCCTACTGTGATGCCACCAATTTCGTACACACGATCGACTGGCAACCGCAGACCGTTCCGGACGCGACGCACCCAGGGGCCGAACAGGTAACCCATCCAGGACCCGTCGCGATAATCGGCGATGACGGCGCAGCGCTGTGTGAGACCCTCGAAGGGGCGGGCTACCAGCCGGCCGTGATGTCCGATGGGGTGTCGCAGGCCCGCTACGTCGTTTACGTCGCGGATTCTGATCCGGCTGGCGCCGACGAGACCGACGTCGACTTCGCCGTCCGGATCTGTACCGAAATCACCGGTCTGGTGCGGACTCTCGCGGAACGCGATGCGGATAAGCCCGCGGCGCTATGGATCCTCACCCGCGGAGTTCACGAATCGGTCGCCCCGTCCGCGCTGCGCCAGAGTTTCCTGTGGGGCCTTGCCGGTGTCATCGCCGCCGAACATCCCGAGCTGTGGGGCGGACTGGTCGATCTCGCGATCAACGACGACTTAGGCGAATTCGGGCCGGCACTTGCCGAACTGCTTGCCAAACCAAGCAAGTCGATCTTGGTGCGTCGTGACGGCGTGGTGCTCGCCCCGGCCTTGGCTCCCGTCCGTGGCGAGCCGGCGCGCAAGTCCTTGCAGTGCAGGCCCGACGCGGCCTACCTCATCACCGGCGGCCTGGGCGCCCTTGGCCTGCTGATGGCCGATTGGCTCGCCGACCGCGGCGCTCATCGATTGGTGTTGACCGGCCGCACGCCATTGCCGCCACGGCGGGACTGGCAACTCGACACCCTCGACACCGAGCTGCGCCGGAGGATCGACGCGATCCGCGCCCTGGAAATGCGCGGGGTGACTGTCGAAGCCGTCGCCGCCGACGTCGGCTGCCGCGAAGACGTGCAGGCCCTGTTGGCCGCGCGCGACCGTGACGGAGCGGCACCGATCCGCGGGATCATCCACGCCGCGGGCATTACCAACGATCAATTGGTGACGAGCATGACCGGCGATGCGGTGCGACAGGTTATGTGGCCGAAGATCGGCGGCAGCCAGGTCCTACACGACGCATTTCCGCCCGGCAGCGTGGACTTCTTCTACTTGACCGCCTCGGCTGCCGGGATATTCGGCATTCCAGGGCAGGGTTCCTACGCCGCCGCCAATTCCTACTTGGACGCGCTGGCGCGGGCGCGCCGGCAACAGGGCTGCCACACCATGAGCCTCGACTGGGTAGCCTGGCGGGGGCTCGGATTGGCCGCGGACGCCCAGCTCGTCAGCGAAGAGCTAGCGCGAATGGGTTCGCGTGACATCACGCCGTCGGAGGCATTCACCGCTTGGGAATTCGTCGATGGCTACGACGTCGCGCAAGCGGTCGTGGTGCCCATGCCCGCTCCGGCGGGCGCCGATGGATCCGGTGCGAACGCTTACCTATTGCCGGCGCGGAACTGGTCGGTGATGGCAGCGACCGAGGTGCGATCCGAGCTCGAACAGGGGTTACGCCGCATCATTGCAGCCGAGCTGCGAGTGCCTGAGAAAGAGCTGGACACCGACCGCCCGTTCGCCGAGTTGGGTCTCAATTCCCTTATGGCAATGGCGATTCGGCGCGAGGCCGAGCAGTTTGTCGGCATCGAGTTGTCTGCCACCATGTTGTTCAACCACCCAACGGTCAAATCACTCGCCAGCTACCTTGCCAAACGTGTGGCACCGCACGATGTGTCACAAGACAACCAGATTTCCGCGCTATCCTCGTCGGCCGGAAGTGTGTTGGACAGTCTATTCGATCGCATCGAATCGGCGCCGCCTGAGGCCGAGAGGTCGGTGTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. {ECO:0000250}.

Family

Unknown

GO

DIM/DIP cell wall layer assembly GO:0071770 biological_process
polyketide synthase complex GO:0034081 cellular_component
cell wall GO:0005618 cellular_component
phosphopantetheine binding GO:0031177 molecular_function
oxidation-reduction process GO:0055114 biological_process
phthiocerol biosynthetic process GO:0097040 biological_process
phenolic phthiocerol biosynthetic process GO:0097041 biological_process
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity GO:0004316 molecular_function
3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0004315 molecular_function
acyl carrier activity GO:0000036 molecular_function
fatty acid biosynthetic process GO:0006633 biological_process

InterPro

UniProt: P9WQE7
GenBank: Rv2931
EnsemblBacteria: Rv2931
Mycobrowser: Rv2931

Summary

Name: Phthiocerol synthesis polyketide synthase type I PpsA (Beta-ketoacyl-acyl-carrier-protein synthase I) (EC 2.3.1.41)
Family: Unknown
Protein Sequence: MTGSISGEADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLSGELSELLGRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGARNSLDEPIAVVGMGCRFPGGISCPEALWDFLCERRSSISQVPPQRWQPFEGGPPEVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQRLLLEVAWEALEHAGIPPGTLRRSATGVFAGACLSEYGAMASADLSQVDGWSNSGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRTQDCHLAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGEGAGVVVLKRLTDAQRDGDRVLAVICGSAVNQDGRSNGLMAPNPAAQMAVLRAAYTNAGMQPSEVDYVEAHGTGTLLGDPIEARALGTVLGRGRPEDSPLLIGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDLRMKVVDTQTEWPATGHPRRAGVSSFGFGGTNAHVVIEQGQEVRPAPGQGLSPAVSTLVVAGKTMQRVSATAGMLADWMEGPGADVALADVAHTLNHHRSRQPKFGTVVARDRTQAIAGLRALAAGQHAPGVVNPADGSPGPGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLHDVLANGEELVGIEQIQLGLIGMQLALTELWCSYGVRPDLVIGHSMGEVAAAVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLELDAPTTEALIADFPQVTLGIYNSPRQTVIAGPTEQIDELIARVRAQNRFASRVNIEVAPHNPAMDALQPAMRSELADLTPRTPTIGIISTTYADLHTQPVFDAEHWATNMRNPVRFQQAIASAGSGADGAYHTFIEISAHPLLTQAIIDTLHSAQPGARYTSLGTLQRDTDDVVTFRTNLNKAHTIHPPHTPHPPEPHPPIPTTPWQHTRHWITTKYPAGSVGSAPRAGTLLGQHTTVATVSASPPSHLWQARLAPDAKPYQGGHRFHQVEVVPASVVLHTILSAATELGYSALSEVRFEQPIFADRPRLIQVVADNRAISLASSPAAGTPSDRWTRHVTAQLSSSPSDSASSLNEHHRANGQPPERAHRDLIPDLAELLAMRGIDGLPFSWTVASWTQHSSNLTVAIDLPEALPEGSTGPLLDAAVHLAALSDVADSRLYVPASIEQISLGDVVTGPRSSVTLNRTAHDDDGITVDVTVAAHGEVPSLSMRSLRYRALDFGLDVGRAQPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPGPVAIIGDDGAALCETLEGAGYQPAVMSDGVSQARYVVYVADSDPAGADETDVDFAVRICTEITGLVRTLAERDADKPAALWILTRGVHESVAPSALRQSFLWGLAGVIAAEHPELWGGLVDLAINDDLGEFGPALAELLAKPSKSILVRRDGVVLAPALAPVRGEPARKSLQCRPDAAYLITGGLGALGLLMADWLADRGAHRLVLTGRTPLPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEAVAADVGCREDVQALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVRQVMWPKIGGSQVLHDAFPPGSVDFFYLTASAAGIFGIPGQGSYAAANSYLDALARARRQQGCHTMSLDWVAWRGLGLAADAQLVSEELARMGSRDITPSEAFTAWEFVDGYDVAQAVVVPMPAPAGADGSGANAYLLPARNWSVMAATEVRSELEQGLRRIIAAELRVPEKELDTDRPFAELGLNSLMAMAIRREAEQFVGIELSATMLFNHPTVKSLASYLAKRVAPHDVSQDNQISALSSSAGSVLDSLFDRIESAPPEAERSV
Mass: 198,835 Da
Length: 1876 Aa

Rv2931 doesn't seem to be a targeted by any drug.

Rv2931 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.