drrA
- Type
- protein_coding
- Name
- drrA
- Locus Name
-
Rv2936
- Product
-
Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA
- Functional Category
-
Cell wall and cell processes
- Location
- 3272214..3273209 (+ strand)
- Gene Length
- 995 bp
- Nucleotides
-
TGCGCAACGACGACATGGCGGTGGTGGTTAACGGGGTTCGCAAGACCTACGGCAAGGGCAAGATTGTGGCCCTCGATGACGTGAGTTTCAAGGTGCGCCGCGGTGAAGTGATCGGGCTGCTGGGCCCCAACGGGGCCGGCAAGACGACCATGGTGGACATCTTGTCGACGCTGACCCGACCGGATGCCGGCTCGGCGATCATCGCTGGCTACGATGTTGTTTCCGAACCGGCCGGTGTACGCCGCTCGATCATGGTCACCGGGCAGCAGGTGGCCGTCGACGACGCGCTTTCCGGTGAGCAGAACCTGGTGTTGTTTGGTCGTCTGTGGGGACTGAGCAAGTCCGCGGCGCGCAAACGCGCCGCCGAACTGCTCGAGCAATTCAGCCTCGTACATGCCGGAAAGAGGCGGGTGGGCACCTACTCCGGCGGAATGCGCCGACGAATAGACATCGCGTGCGGATTGGTGGTCCAACCCCAGGTGGCGTTCTTAGACGAGCCCACCACCGGGCTCGATCCCAGGAGCCGGCAAGCTATTTGGGATCTGGTGGCCAGCTTCAAGAAGCTGGGCATTGCCACGTTGTTGACCACGCAGTATCTCGAGGAGGCGGATGCGCTCAGTGACCGCATCATCCTGATCGATCACGGCATAATCATCGCCGAAGGCACCGCGAATGAACTCAAGCACCGCGCCGGCGACACCTTCTGCGAAATAGTGCCCCGCGATCTGAAGGATCTGGACGCTATCGTCGCGGCGCTCGGTTCGCTGTTGCCCGAGCACCACAGGGCGATGCTGACGCCCGACTCAGACCGCATTACGATGCCGGCGCCTGACGGCATACGTATGCTCGTCGAGGCAGCGCGCCGGATCGACGAGGCGAGGATCGAGCTAGCCGATATTGCGCTGCGCCGACCGTCACTCGATCACGTATTCCTGGCCATGACGACCGATCCCACCGAGTCTCTGACCCATCTGGTGTCGGGGTCCGCGCGATGA
- Drug Resistance
- Mutations
- Function
- Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP. {ECO:0000269|PubMed:12057006}.
- Family
-
ABC transporter superfamily, Drug exporter-1 (DrugE1) (TC 3.A.1.105) family
- GO
-
- growth of symbiont in host cell GO:0044119 biological_process
- doxorubicin transport GO:1900753 biological_process
- response to antibiotic GO:0046677 biological_process
- transmembrane transport GO:0055085 biological_process
- daunorubicin transport GO:0043215 biological_process
- cell wall GO:0005618 cellular_component
- ATP binding GO:0005524 molecular_function
- plasma membrane GO:0005886 cellular_component
- ATPase activity GO:0016887 molecular_function
- lipid transport GO:0006869 biological_process
- InterPro
Summary
- Name
- Doxorubicin resistance ATP-binding protein DrrA (EC 3.6.3.-)
- Family
- ABC transporter superfamily, Drug exporter-1 (DrugE1) (TC 3.A.1.105) family
- Protein Sequence
-
MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQVAVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTYSGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFKKLGIATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVPRDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRIDEARIELADIALRRPSLDHVFLAMTTDPTESLTHLVSGSAR
- Mass
- 35,818 Da
- Length
- 331 Aa
Rv2936 doesn't seem to be a targeted by any drug.
Rv2936 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis.
- Biochem J. 2002 Oct 1;367(Pt 1):279-85. doi: 10.1042/BJ20020615.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.