drrB
- Type
- protein_coding
- Name
- drrB
- Locus Name
-
Rv2937
- Product
-
Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB
- Functional Category
-
Cell wall and cell processes
- Location
- 3273206..3274075 (+ strand)
- Gene Length
- 869 bp
- Nucleotides
-
TGAGCGGCCCGGCCATAGATGCGAGCCCCGCCCTGACCTTCAACCAGTCAAGCGCGAGCATTCAGCAGCGACGCTTATCGACCGGGCGACAGATGTGGGTGCTCTATCGGCGTTTCGCCGCGCCGAGCCTACTCAACGGTGAAGTACTCACCACGGTGGGCGCGCCGATAATTTTCATGGTGGGCTTCTATATCCCGTTCGCCATACCGTGGAACCAATTTGTGGGTGGCGCCAGCTCGGGCGTCGCCAGCAACTTAGGGCAATACATCACGCCGTTGGTCACACTGCAGGCGGTCTCGTTCGCCGCGATCGGGTCGGGCTTTCGAGCCGCGACCGATTCGCTGCTAGGCGTCAATCGTCGGTTTCAGTCCATGCCGATGGCCCCGTTGACGCCACTGCTTGCCCGCGTGTGGGTGGCTGTGGACCGATGCTTCACGGGTTTGGTGATATCGCTAGTTTGCGGCTACGTCATCGGATTCCGTTTTCATCGCGGGGCCCTCTATATCGTCGGTTTTTGCCTACTGGTTATCGCGATCGGGGCTGTGCTGTCATTCGCCGCTGACCTGGTTGGCACCGTTACCAGGAACCCAGACGCGATGCTGCCGCTGCTGAGCTTGCCCATTTTGATCTTCGGACTGCTGTCCATTGGTCTCATGCCGTTAAAGCTGTTTCCGCACTGGATCCATCCATTTGTTCGCAACCAGCCGATCTCCCAGTTCGTCGCGGCGCTGCGGGCATTGGCCGGAGATACCACCAAGACAGCCTCACAGGTGAGTTGGCCTGTGATGGCTCCGACGTTGACGTGGTTGTTCGCTTTCGTGGTGATCCTGGCGCTTTCATCCACCATTGTTTTGGCTAGGCGGCCATGA
- Drug Resistance
- Mutations
- Function
- Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane. {ECO:0000269|PubMed:12057006}.
- Family
-
ABC-2 integral membrane protein family
- GO
-
- DIM/DIP cell wall layer assembly GO:0071770 biological_process
- doxorubicin transport GO:1900753 biological_process
- response to antibiotic GO:0046677 biological_process
- transmembrane transport GO:0055085 biological_process
- lipid biosynthetic process GO:0008610 biological_process
- daunorubicin transport GO:0043215 biological_process
- ATP-binding cassette (ABC) transporter complex GO:0043190 cellular_component
- plasma membrane GO:0005886 cellular_component
- InterPro
Summary
- Name
- Doxorubicin resistance ABC transporter permease protein DrrB
- Family
- ABC-2 integral membrane protein family
- Protein Sequence
-
MSGPAIDASPALTFNQSSASIQQRRLSTGRQMWVLYRRFAAPSLLNGEVLTTVGAPIIFMVGFYIPFAIPWNQFVGGASSGVASNLGQYITPLVTLQAVSFAAIGSGFRAATDSLLGVNRRFQSMPMAPLTPLLARVWVAVDRCFTGLVISLVCGYVIGFRFHRGALYIVGFCLLVIAIGAVLSFAADLVGTVTRNPDAMLPLLSLPILIFGLLSIGLMPLKLFPHWIHPFVRNQPISQFVAALRALAGDTTKTASQVSWPVMAPTLTWLFAFVVILALSSTIVLARRP
- Mass
- 31,109 Da
- Length
- 289 Aa
Rv2937 doesn't seem to be a targeted by any drug.
Rv2937 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis.
- Biochem J. 2002 Oct 1;367(Pt 1):279-85. doi: 10.1042/BJ20020615.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.