fadD29
- Type
- protein_coding
- Name
- fadD29
- Locus Name
-
Rv2950c
- Product
-
Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)
- Functional Category
-
Lipid metabolism
- Location
- 3300596..3302455 (- strand)
- Gene Length
- 1859 bp
- Nucleotides
-
ATGAAAACCAACTCGTCATTTCATGCCGCGGGCGAGGTGGCGACACAACCGGCATGGGGCACCGGTGAGCAAGCGGCACAACCGCTGAACGGGAGCACATCGCGATTCGCTATGAGCGAGTCGTCGCTCGCTGATCTCCTACAGAAGGCGGCGAGCCAGTACCCCAATCGCGCGGCGTACAAGTTCATTGACTATGACACGGATCCGGCTGGCTTCACCGAAACCGTGACGTGGTGGCAAGTCCACCGGCGAGCGATGATCGTGGCAGAGGAGCTCTGGATATACGCGTCAAGCGGTGATCGGGTCGCGATATTGGCCCCGCAGGGCCTTGAATACATCATCGCCTTTATGGGTGTGCTGCAGGCTGGTCTCATTGCGGTTCCTCTTCCGGTGCCACAATTCGGCATTCACGACGAACGAATATCTTCGGCATTACGAGACTCTGCGCCGTCCATTATTCTTACGACCTCGTCGGTTATTGACGAGGTCACGACATATGCGCCACATGCGTGCGCCGCACAGGGCCAGTCCGCGCCCATCGTCGTGGCTGTGGACGCTCTGGACTTGAGCTCATCCAGAGCGCTCGATCCGACTCGGTTCGAGCGTCCGAGCACAGCATATCTACAGTACACATCCGGTTCGACCCGCGCGCCGGCCGGTGTTGTCCTCTCGCACAAGAATGTCATCACCAACTGCGTACAGCTAATGTCCGATTACATCGGGGATTCGGAAAAGGTTCCGTCAACTCCCGTATCGTGGCTGCCGTTCTATCACGACATGGGGTTGATGCTGGGCATCATTCTCCCGATGATCAATCAAGACACCGCGGTGTTGATGAGTCCCATGGCATTCTTGCAGCGGCCGGCCCGTTGGATGCAATTATTAGCCAAACACCGCGCACAGATTTCCAGCGCACCGAATTTCGGTTTCGAATTGGCGGTACGCAGAACATCCGACGACGATATGGCTGGACTTGACCTCGGGCATGTGCGGACGATCGTCACCGGCGCCGAACGAGTAAACGTCGCGACGCTGCGGCGCTTCACCGAGCGGTTCGCCCCGTTCAACCTCAGCGAGACGGCAATCCGGCCGTCATATGGGCTCGCGGAGGCGACGGTGTACGTGGCGACCGCCGGACCGGGACGCGCGCCGAAGAGTGTTTGCTTTGACTACCAGCAGCTGTCGGTCGGTCAGGCGAAGCGTGCCGAGAACGGCAGCGAGGGAGCCAACCTGGTGAGTTATGGAGCTCCCCGGGCGTCAACCGTGCGGATCGTCGACCCCGAAACCAGGATGGAGAATCCCGCGGGGACGGTTGGCGAAATCTGGGTGCAGGGAGACAACGTCGGCTTGGGCTACTGGCGCAACCCGCAGCAGACGGAGGCGACGTTCCGCGCGCGGCTCGTCACTCCCTCGCCCGGGACTTCGGAAGGTCCGTGGCTGCGGACCGGAGACCTCGGCGTCATTTTCGAGGGCGAACTGTTCATCACGGGTCGCATCAAGGAGCTGTTGGTGGTGGATGGGGCCAACCACTATCCGGAAGACATCGAGGCGACGATCCAGGAAATCACCGGCGGCCGGGTTGTGGCGATTGCGGTGCCCGATGACCGTACTGAAAAGCTGGTAACCATTATCGAACTCATGAAGCGGGGTCGCACAGATGAGGAGGAAAAGAATCGACTCCGCACCGTCAAACGTGAAGTCGCCTCCGCGATATCCAGGTCACATCGTCTGCGCGTCGCGGATGTCGTTATGGTGGCGCCGGGTTCTATTCCGGTCACCACCAGCGGTAAGGTTCGGCGTTCGGCCAGCGTTGAGCGTTACCTACATCACGAATTCAGCCGCCTAGATGCTATGGCATA
- Drug Resistance
- Mutations
- Function
- Catalyzes the activation of the long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Involved in the biosynthesis of phenolphthiocerol, which is an important intermediate in the biosynthesis of phenolic glycolipid (mycosid B). {ECO:0000269|PubMed:15042094, ECO:0000269|PubMed:20553505}.
- Family
-
ATP-dependent AMP-binding enzyme family
- GO
-
- Actinobacterium-type cell wall biogenesis GO:0071766 biological_process
- adenylyltransferase activity GO:0070566 molecular_function
- lipid biosynthetic process GO:0008610 biological_process
- ATP binding GO:0005524 molecular_function
- ligase activity GO:0016874 molecular_function
- acid-thiol ligase activity GO:0016878 molecular_function
- phthiocerol biosynthetic process GO:0097040 biological_process
- fatty acid biosynthetic process GO:0006633 biological_process
- InterPro
Summary
- Name
- 4-hydroxyphenylalkanoate adenylyltransferase (EC 6.2.1.51) (Acyl-AMP synthase) (Long-chain-fatty-acid--AMP ligase FadD29) (FAAL)
- Family
- ATP-dependent AMP-binding enzyme family
- Protein Sequence
-
MKTNSSFHAAGEVATQPAWGTGEQAAQPLNGSTSRFAMSESSLADLLQKAASQYPNRAAYKFIDYDTDPAGFTETVTWWQVHRRAMIVAEELWIYASSGDRVAILAPQGLEYIIAFMGVLQAGLIAVPLPVPQFGIHDERISSALRDSAPSIILTTSSVIDEVTTYAPHACAAQGQSAPIVVAVDALDLSSSRALDPTRFERPSTAYLQYTSGSTRAPAGVVLSHKNVITNCVQLMSDYIGDSEKVPSTPVSWLPFYHDMGLMLGIILPMINQDTAVLMSPMAFLQRPARWMQLLAKHRAQISSAPNFGFELAVRRTSDDDMAGLDLGHVRTIVTGAERVNVATLRRFTERFAPFNLSETAIRPSYGLAEATVYVATAGPGRAPKSVCFDYQQLSVGQAKRAENGSEGANLVSYGAPRASTVRIVDPETRMENPAGTVGEIWVQGDNVGLGYWRNPQQTEATFRARLVTPSPGTSEGPWLRTGDLGVIFEGELFITGRIKELLVVDGANHYPEDIEATIQEITGGRVVAIAVPDDRTEKLVTIIELMKRGRTDEEEKNRLRTVKREVASAISRSHRLRVADVVMVAPGSIPVTTSGKVRRSASVERYLHHEFSRLDAMA
- Mass
- 67,447 Da
- Length
- 619 Aa
Rv2950c doesn't seem to be a targeted by any drug.
Rv2950c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.
- FEBS J. 2010 Jun;277(12):2715-25. doi: 10.1111/j.1742-464X.2010.07688.x.
- Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria.
- Nature. 2004 Mar 25;428(6981):441-5. doi: 10.1038/nature02384.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.