thiL
- Type
- protein_coding
- Name
- thiL
- Locus Name
-
Rv2977c
- Product
-
Probable thiamine-monophosphate kinase ThiL (thiamine-phosphate kinase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3332787..3333788 (- strand)
- Gene Length
- 1001 bp
- Nucleotides
-
GTGACCACTAAAGATCACTCACTTGCAACGGAGTCCCCGACGCTGCAGCAGCTCGGCGAGTTCGCCGTGATCGACCGGCTGGTGCGGGGGCGCCGACAACCCGCCACGGTACTGCTCGGGCCCGGCGACGATGCCGCGCTGGTGTCTGCCGGCGATGGTCGCACTGTGGTGTCGACGGACATGCTGGTGCAAGATAGTCACTTCCGGCTGGACTGGTCGACACCGCAGGACGTCGGCCGCAAGGCGATCGCCCAGAATGCCGCCGACATCGAGGCGATGGGGGCGCGGGCCACCGCGTTCGTGGTCGGCTTTGGAGCACCCGCTGAGACGCCGGCGGCGCAGGCGAGCGCGTTGGTCGACGGAATGTGGGAGGAGGCGGGGCGCATTGGTGCCGGCATCGTCGGCGGCGATCTGGTCAGCTGCCGGCAGTGGGTGGTGTCGGTCACCGCGATTGGTGACCTTGACGGTCGTGCCCCGGTGCTGCGCTCCGGGGCGAAGGCCGGCTCGGTGCTGGCCGTCGTCGGTGAGCTGGGCCGCTCGGCTGCTGGCTATGCGCTGTGGTGCAACGGGATTGAAGACTTCGCCGAACTGCGCCGCCGCCATTTGGTGCCGCAGCCGCCCTACGGCCACGGCGCGGCGGCCGCGGCTGTCGGGGCTCAAGCGATGATCGATGTCTCCGACGGGCTGCTCGCCGATCTGCGGCACATCGCCGAGGCATCCGGCGTGCGCATCGACCTGTCCGCCGCGGCGTTGGCCGCTGACCGCGACGCTTTGACTGCGGCCGCAACCGCTCTGGGCACCGACCCCTGGCCGTGGGTGCTAAGCGGGGGTGAAGATCATGCCCTGGTCGCCTGTTTCGTCGGTCCGGTGCCGGCCGGGTGGCGCACCATTGGCCGGGTTCTCGACGGGCCGGCTAGGGTGCTGGTCGACGGCGAGGAGTGGACTGGATACGCGGGCTGGCAATCGTTTGGGGAGCCAGACAATCAAGGTTCGCTAGGGTG
- Drug Resistance
- Mutations
- Function
- Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. {ECO:0000255|HAMAP-Rule:MF_02128}.
- Family
-
Thiamine-monophosphate kinase family
- GO
-
- magnesium ion binding GO:0000287 molecular_function
- thiamine-phosphate kinase activity GO:0009030 molecular_function
- thiamine biosynthetic process GO:0009228 biological_process
- thiamine diphosphate biosynthetic process GO:0009229 biological_process
- ATP binding GO:0005524 molecular_function
- InterPro
Summary
- Name
- Thiamine-monophosphate kinase (TMP kinase) (Thiamine-phosphate kinase) (EC 2.7.4.16)
- Family
- Thiamine-monophosphate kinase family
- Protein Sequence
-
MTTKDHSLATESPTLQQLGEFAVIDRLVRGRRQPATVLLGPGDDAALVSAGDGRTVVSTDMLVQDSHFRLDWSTPQDVGRKAIAQNAADIEAMGARATAFVVGFGAPAETPAAQASALVDGMWEEAGRIGAGIVGGDLVSCRQWVVSVTAIGDLDGRAPVLRSGAKAGSVLAVVGELGRSAAGYALWCNGIEDFAELRRRHLVPQPPYGHGAAAAAVGAQAMIDVSDGLLADLRHIAEASGVRIDLSAAALAADRDALTAAATALGTDPWPWVLSGGEDHALVACFVGPVPAGWRTIGRVLDGPARVLVDGEEWTGYAGWQSFGEPDNQGSLG
- Mass
- 34,331 Da
- Length
- 333 Aa
Rv2977c doesn't seem to be a targeted by any drug.
-
-
Thiamine metabolism mtu00730
mtu00730PATHWAY_MAP mtu00730 Thiamine metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.