Gene - combatTB X

Rv2983

Type: protein_coding
Name: Rv2983
Locus Name: Rv2983
Product: Conserved hypothetical alanine rich protein
Functional Category: Conserved hypotheticals
Location: 3339118..3339762 (+ strand)
Gene Length: 644 bp
Nucleotides: TGAGCGGCACACCGGACGACGGCGATATCGGCTTGATCATCGCCGTCAAGCGCTTGGCCGCGGCCAAAACCAGGCTGGCCCCGGTGTTCTCGGCGCAGACTCGCGAGAACGTGGTGCTGGCCATGCTCGTCGACACGTTGACCGCCGCGGCGGGTGTCGGTTCACTGCGCTCGATCACTGTTATCACCCCCGACGAAGCCGCGGCGGCTGCGGCGGCCGGGCTGGGCGCCGATGTACTGGCCGACCCGACACCCGAAGACGATCCCGACCCACTGAACACCGCCATCACCGCTGCCGAACGCGTGGTTGCCGAAGGGGCCTCCAACATCGTTGTGCTGCAAGGCGATTTGCCGGCATTACAGACACAGGAACTCGCCGAGGCAATCTCGGCCGCACGCCACCATCGGCGCAGCTTCGTCGCCGACCGGCTTGGGACCGGCACCGCGGTACTGTGTGCGTTCGGCACCGCGCTGCACCCGCGGTTCGGGCCGGATTCGTCCGCGCGGCACCGCCGTTCGGGCGCTGTCGAGCTGACAGGAGCCTGGCCGGGCCTGCGCTGCGATGTCGACACCCCCGCCGACCTGACGGCCGCACGCCAGCTCGGGGTAGGGCCCGCGACCGCGCGAGCGGTCGCACATCGTTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. {ECO:0000255|HAMAP-Rule:MF_02114}.

Family

CofC family

GO

coenzyme biosynthetic process GO:0009108 biological_process
GTP binding GO:0005525 molecular_function
phospholactate guanylyltransferase activity GO:0043814 molecular_function

InterPro

UniProt: P9WP83
GenBank: Rv2983
EnsemblBacteria: Rv2983
Mycobrowser: Rv2983

Summary

Name: 2-phospho-L-lactate guanylyltransferase (LP guanylyltransferase) (EC 2.7.7.68)
Family: CofC family
Protein Sequence: MSGTPDDGDIGLIIAVKRLAAAKTRLAPVFSAQTRENVVLAMLVDTLTAAAGVGSLRSITVITPDEAAAAAAAGLGADVLADPTPEDDPDPLNTAITAAERVVAEGASNIVVLQGDLPALQTQELAEAISAARHHRRSFVADRLGTGTAVLCAFGTALHPRFGPDSSARHRRSGAVELTGAWPGLRCDVDTPADLTAARQLGVGPATARAVAHR
Mass: 21,819 Da
Length: 214 Aa

Rv2983 doesn't seem to be a targeted by any drug.

Methane metabolism mtu00680
mtu00680
Metabolism; Energy metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.