serA1
- Type
- protein_coding
- Name
- serA1
- Locus Name
-
Rv2996c
- Product
-
Probable D-3-phosphoglycerate dehydrogenase SerA1 (PGDH)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3353483..3355069 (- strand)
- Gene Length
- 1586 bp
- Nucleotides
-
GTGAGCCTGCCTGTTGTGTTGATCGCCGACAAACTTGCCCCATCAACGGTTGCCGCCTTGGGAGATCAGGTCGAGGTGCGCTGGGTTGACGGTCCGGACCGAGACAAGCTGCTGGCCGCGGTGCCCGAAGCGGACGCGCTGCTGGTGCGATCGGCCACCACGGTTGACGCCGAGGTGCTGGCCGCCGCCCCCAAGCTCAAGATCGTCGCGCGCGCCGGCGTCGGGCTGGACAACGTCGACGTGGACGCCGCGACGGCCCGCGGCGTGCTGGTGGTCAACGCCCCGACGTCGAACATCCACAGCGCCGCGGAGCATGCGCTGGCGCTGCTGCTGGCCGCCTCACGCCAGATTCCGGCGGCCGACGCGTCGCTGCGCGAGCACACCTGGAAGCGTTCGTCGTTTTCCGGTACCGAGATCTTCGGCAAAACCGTCGGCGTGGTGGGTCTGGGCCGCATCGGGCAGTTGGTCGCCCAGCGGATCGCTGCGTTCGGCGCTTACGTCGTCGCCTATGACCCGTACGTTTCGCCGGCCCGTGCGGCGCAGCTGGGCATCGAACTGCTGTCCCTGGACGACCTGCTGGCCCGCGCCGATTTCATCTCGGTGCACCTACCGAAAACACCGGAGACGGCGGGACTGATCGACAAGGAGGCGCTGGCGAAGACCAAGCCGGGCGTCATCATCGTCAACGCCGCGCGCGGCGGCCTGGTGGACGAGGCGGCACTGGCCGACGCGATCACCGGCGGCCACGTGCGGGCGGCCGGTCTGGACGTGTTCGCCACCGAACCGTGCACCGACAGCCCGCTGTTCGAGCTGGCACAGGTGGTGGTCACACCGCATCTGGGTGCGTCCACCGCGGAGGCGCAGGACCGGGCGGGCACCGACGTCGCCGAGAGCGTGCGGCTGGCCCTGGCAGGGGAATTCGTGCCCGACGCGGTCAACGTCGGCGGCGGAGTGGTCAACGAGGAGGTGGCGCCCTGGCTGGATCTGGTGCGTAAGCTCGGCGTGCTGGCGGGTGTGTTGTCCGACGAACTGCCGGTGTCGTTGTCGGTGCAGGTGCGCGGTGAGCTGGCCGCCGAAGAGGTTGAGGTGCTGCGCCTTTCGGCGCTGCGCGGCCTGTTCTCGGCGGTGATCGAGGATGCGGTGACATTTGTCAACGCACCGGCATTGGCCGCCGAACGTGGCGTCACCGCCGAGATCTGTAAGGCCTCGGAAAGCCCCAACCACCGCAGCGTCGTCGACGTTCGCGCGGTCGGCGCGGACGGTTCGGTGGTGACCGTCTCGGGCACGCTGTATGGCCCACAGCTGTCGCAGAAGATCGTGCAGATCAACGGCCGCCACTTTGATCTGCGCGCCCAGGGGATCAACCTGATCATCCACTACGTCGACCGGCCGGGAGCGCTGGGCAAGATCGGCACGTTGCTGGGGACGGCCGGGGTGAATATCCAGGCCGCGCAGCTCTCCGAAGACGCCGAAGGCCCGGGCGCGACGATTCTGCTGCGGCTGGACCAAGACGTGCCCGACGACGTGCGGACGGCGATCGCGGCGGCGGTGGACGCCTACAAGCTCGAGGTTGTCGATCTGTCGTG
- Drug Resistance
- Mutations
- Function
- Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. {ECO:0000250|UniProtKB:P0A9T0}.
- Family
-
D-isomer specific 2-hydroxyacid dehydrogenase family
- GO
-
- cell wall GO:0005618 cellular_component
- plasma membrane GO:0005886 cellular_component
- L-serine biosynthetic process GO:0006564 biological_process
- cellular amino acid metabolic process GO:0006520 biological_process
- phosphoglycerate dehydrogenase activity GO:0004617 molecular_function
- NAD binding GO:0051287 molecular_function
- InterPro
1YGY
- Name
- D-3-phosphoglycerate dehydrogenase (PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399)
- Family
- D-isomer specific 2-hydroxyacid dehydrogenase family
- Protein Sequence
-
MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
- Mass
- 54,554 Da
- Length
- 528 Aa
Summary
Rv2996c doesn't seem to be a targeted by any drug.
-
-
Methane metabolism mtu00680
mtu00680Metabolism; Energy metabolism
-
-
-
Cysteine and methionine metabolism mtu00270
mtu00270Metabolism; Amino acid metabolism
-
-
-
Glycine, serine and threonine metabolism mtu00260
mtu00260Metabolism; Amino acid metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.