Gene - combatTB X

PPE46

Type: protein_coding
Name: PPE46
Locus Name: Rv3018c
Product: PPE family protein PPE46
Functional Category: Pe/ppe
Location: 3376939..3378243 (- strand)
Gene Length: 1304 bp
Nucleotides: GTGACGGCGCCGGTGTGGTTGGCGTCGCCGCCGGAGGTGCATTCGGCGCTGCTAAGTGCTGGTCCGGGGCCGGGTTCGTTGCAGGCGGCCGCGGCGGGGTGGAGCGCGTTAAGCGCCGAGTACGCCGCTGTGGCGCAAGAGTTGAGCGTGGTGGTGGCCGCGGTGGGGGCCGGGGTGTGGCAGGGTCCCAGTGCTGAGTTGTTTGTGGCCGCCTATGTGCCGTATGTGGCGTGGTTGGTGCAGGCCAGTGCGGATAGCGCGGCGGCGGCCGGTGAGCATGAGGCCGCGGCGGCTGGCTATGTTTGTGCGTTGGCGGAGATGCCGACGTTGCCGGAGTTGGCGGCCAACCACCTCACGCATGCGGTGTTGGTGGCGACGAATTTCTTTGGGATCAACACGATCCCGATCGCGCTCAACGAGGCCGACTATGTGCGGATGTGGGTCCAGGCGGCCACCGTGATGAGCGCCTATGAGGCGGTGGTGGGTGCCGCGCTGGTGGCCACACCACACACCGGCCCGGCACCGGTCATCGTCAAACCCGGCGCCAATGAAGCCAGCAACGCCGTGGCCGCCGCAACCATAACCCCATTCCCATGGCACGAAATTGTACAGTTTTTAGAAGAAACGTTCGCAGCATATGACCAGTATCTGTCCGCTTTGCTTTCCGAACTCCCTGCGGTGGCTTGGGTTTGGTTCCAGCTCTTTGTGGATATCCTGGGTTTCAACATTATTGGGTTCATTATTACGTTGGCATCCAATGCTCAACTATTGACAGAGTTCGCTATCAATGCTTCTTATGTTGCGGTCGGATTATTGTATGCCATTGCGGGCGTTATAGACATAGTTGTCGAGTGGGTTATTGGGAATCTGTTTGGTGTTGTTCCCCTTTTGGGGGGGCCGTTGTTGGGGGCGTTGGCCGCTGCTGTGGTTCCGGGTGTAGCTGGGTTGGCCGGGGTGGCGGGATTGGCCGCTCTGCCGGCGGTGGGTGCGGCTGCTGGCGCGCCGGCGGCGTTGGTGGGCAGTGTGGCGCCGGTGTCGGGTGGTGTGGTGTCGCCGCAGGCGCGGTTGGTGTCGGCGGTGGAGCCGGCTCCCGCGAGCACGTCGGTGTCGGTGCTGGCTTCTGATCGGGGTGCTGGGGCGTTGGGGTTTGTTGGGACGGCTGGCAAGGAGTCGGTTGGGCAGCCGGCGGGGTTGACGGTGTTGGCCGATGAGTTTGGTGATGGTGCGCCGGTGCCGATGCTGCCGGGCAGCTGGGGGCCGGATTTGGTCGGTGTGGCCGGTGATGGGGGGTTGGTGTCAGTTTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Mycobacterial PPE family

GO

growth of symbiont in host cell GO:0044119 biological_process

InterPro

UniProt: P9WHY9
GenBank: Rv3018c
EnsemblBacteria: Rv3018c
Mycobrowser: Rv3018c

Summary

Name: Uncharacterized PPE family protein PPE46
Family: Mycobacterial PPE family
Protein Sequence: MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVAAATITPFPWHEIVQFLEETFAAYDQYLSALLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIVVEWVIGNLFGVVPLLGGPLLGALAAAVVPGVAGLAGVAGLAALPAVGAAAGAPAALVGSVAPVSGGVVSPQARLVSAVEPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTVLADEFGDGAPVPMLPGSWGPDLVGVAGDGGLVSV
Mass: 43,029 Da
Length: 434 Aa

Rv3018c doesn't seem to be a targeted by any drug.

Rv3018c doesn't seem to be involved in any pathway.

targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.