Gene - combatTB X

Type: protein_coding
Name: esxR
Locus Name: Rv3019c
Product: Secreted ESAT-6 like protein EsxR (TB10.3) (ESAT-6 like protein 9)
Functional Category: Cell wall and cell processes
Location: 3378711..3379001 (- strand)
Gene Length: 290 bp
Nucleotides: ATGTCGCAGATTATGTACAACTATCCGGCGATGATGGCTCATGCCGGGGACATGGCCGGTTATGCGGGCACGCTGCAGAGCTTGGGGGCCGATATCGCCAGTGAGCAGGCCGTGCTGTCCAGTGCTTGGCAGGGTGATACCGGGATCACGTATCAGGGCTGGCAGACCCAGTGGAACCAGGCCCTAGAGGATCTGGTGCGGGCCTATCAGTCGATGTCTGGCACCCATGAGTCCAACACCATGGCGATGTTGGCTCGAGATGGGGCCGAAGCCGCCAAGTGGGGCGGCTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

WXG100 family, ESAT-6 subfamily

GO

InterPro

Summary

Name: ESAT-6-like protein EsxR (TB10.3)
Family: WXG100 family, ESAT-6 subfamily
Protein Sequence: MSQIMYNYPAMMAHAGDMAGYAGTLQSLGADIASEQAVLSSAWQGDTGITYQGWQTQWNQALEDLVRAYQSMSGTHESNTMAMLARDGAEAAKWGG
Mass: 10,312 Da
Length: 96 Aa

Rv3019c doesn't seem to be a targeted by any drug.

Rv3019c doesn't seem to be involved in any pathway.

The crystal structure of the Mycobacterium tuberculosis Rv3019c-Rv3020c ESX complex reveals a domain-swapped heterotetramer.: Protein Sci. 2010 Sep;19(9):1692-703. doi: 10.1002/pro.451.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family: towards an understanding of the rules governing complex formation and thereby functional flexibility.: FEMS Microbiol Lett. 2004 Sep 1;238(1):255-62. doi: 10.1016/j.femsle.2004.07.043.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.