Function

Catalyzes the dephosphorylation of O-phospho-L-serine into L-serine, a step in the L-serine biosynthetic pathway (PubMed:25037224, PubMed:25521849). Exhibits high specificity for L-phosphoserine compared to substrates like L-phosphothreonine (5% relative activity) and L-phosphotyrosine (1.7% relative activity) (PubMed:25521849). {ECO:0000269|PubMed:25037224, ECO:0000269|PubMed:25521849}.; FUNCTION: In the host, induces significant cytoskeleton rearrangements through cofilin dephosphorylation and its subsequent activation, and affects the expression of genes that regulate actin dynamics. It specifically interacts with HSP90, HSP70 and HSP27 that block apoptotic pathways but not with other HSPs. Also interacts with GAPDH. It actively dephosphorylates MAP kinase p38 and NF-kappa B p65 (specifically at Ser-536) that play crucial roles in inflammatory and immune responses. This in turn leads to down-regulation of Interleukin 8, a chemotactic and inflammatory cytokine. Thus might help the pathogen to evade the host's immune response (PubMed:26984196). Exogenous addition of purified SerB2 protein to human THP-1 cells (that can be differentiated into macrophage-like cells) induces microtubule rearrangements; the phosphatase activity is co-related to the elicited rearrangements, while addition of the ACT-domains alone elicits no rearrangements (PubMed:25521849). {ECO:0000269|PubMed:25521849, ECO:0000269|PubMed:26984196}.

Family

HAD-like hydrolase superfamily, SerB family

GO

• phosphoserine phosphatase activity GO:0004647 molecular_function
• amino acid binding GO:0016597 molecular_function
• protein serine/threonine phosphatase activity GO:0004722 molecular_function
• dephosphorylation GO:0016311 biological_process
• phosphatase activity GO:0016791 molecular_function
• L-serine biosynthetic process GO:0006564 biological_process
• protein dephosphorylation GO:0006470 biological_process
• cytoplasm GO:0005737 cellular_component
• extracellular region GO:0005576 cellular_component
• magnesium ion binding GO:0000287 molecular_function
• host cell cytosol GO:0044164 cellular_component

InterPro

• IPR002912
• IPR036412
• IPR023214
• IPR023190

UniProt

O53289

GenBank

Rv3042c

EnsemblBacteria

Rv3042c

Mycobrowser

Rv3042c

Rv3042c doesn't seem to be a targeted by any drug.

• 

  Methane metabolism mtu00680

  mtu00680

  Metabolism; Energy metabolism

• 

  Glycine, serine and threonine metabolism mtu00260

  mtu00260

  Metabolism; Amino acid metabolism