Gene - combatTB X

cstA

Type: protein_coding
Name: cstA
Locus Name: Rv3063
Product: Probable carbon starvation protein A homolog CstA
Functional Category: Virulence, detoxification, adaptation
Location: 3427243..3429519 (+ strand)
Gene Length: 2276 bp
Nucleotides: TGGCAGCGCCGACCCCGTCGAATCGGATCGAAGAACGCTCCGGACACGCCAGCTGCGTCCGCGCCGATGCCGACCTGCCACCCGTGGCCATCCTCGGTCGCTCCCCCATCACGCTTCGGCACAAGATCTTCTTCGTGGCCGTTGCCGTGATCGGCGCTCTCGCCTGGACCGTCGTCGCGTTCTTCCGCAACGAGCCGGTCAACGCGGTCTGGATCGTGGTCGCAGCGGGCTGCACCTACATCATCGGGTTCCGGTTTTATGCGCGGCTGATCGAAATGAAAGTCGTCCGTCCCCGCGACGATCACGCCACCCCGGCCGAAATCCTCGACGACGGCACCGACTACGTGCCCACCGACCGGCGGGTGGTATTCGGACACCACTTCGCCGCCATCGCCGGTGCCGGGCCGCTTGTCGGACCAGTACTGGCCACCCAGATGGGTTACTTACCCAGCAGCATCTGGATTGTCGTCGGCGCGGTGCTGGCCGGATGTGTCCAGGACTACCTGGTGTTGTGGATCTCCGTGCGGCGGCGTGGCCGCTCCCTGGGTCAGATGGTTCGCGACGAACTCGGCGCCACCGCCGGAGTGGCCGCCCTCGTTGGAATCCCGGTCATTATCACCATTGTGATCGCGGTGCTGGCGCTGGTGGTCGTGCGGGCCCTGGCCAAGAGCCCATGGGGCGTCTTCTCGATCGCCATGACCATCCCCATCGCCATCTTCATGGGCTGCTACTTGCGGTTCCTACGTCCCGGGCGGGTGTCGGAAGTTTCATTGATCGGGATCGGACTGCTGCTGCTCGCCGTTGTCTCCGGTGATTGGGTTGCCCATACCTCCTGGGGCGCAGCGTGGTTCAGCTTGTCACCGGTGACACTGTGTTGGCTTCTCATCAGCTATGGCTTCGCAGCTTCGGTGCTGCCGGTGTGGCTGCTGCTCGCGCCACGCGACTACCTGTCAACGTTCATGAAGGTCGGCACCATCGCGCTTCTCGCGATCGGTGTTTGTGCGGCTCACCCGATCATCGAGGCCCCAGCGGTGTCGAAATTCGCCGGTAGCGGCAACGGCCCGGTGTTCGCCGGCTCACTGTTTCCATTCCTGTTCATCACCATCGCGTGCGGGGCGCTGTCTGGATTCCACGCGCTCATCTGCTCGGGCACGACGCCGAAGATGCTGGAGAAGGAAGGCCAGATGCGCGTGATCGGCTACGGCGGCATGATGACCGAGTCCTTCGTCGCCGTCATAGCACTACTCACCGCGGCGATCCTCGACCAGCACCTATACTTCACCCTCAACGCGCCGTCCCTGCATACCCACGACAGCGCAGCCACCGCCGCCAAGTACGTCAACGGGCTCGGTTTGACGGGCTCACCGGTGACCCCAGACCACATCAGCCAGGCCGCCGCCAGCGTCGGCGAACAGACGATCGTGTCGCGCACCGGCGGTGCGCCGACGCTGGCGTTCGGCATGGCGGAGATGCTGCATCGAGTGGTCGGCGGTGTGGGCCTCAAGGCGTTCTGGTATCACTTCGCGATCATGTTTGAGGCTCTGTTCATCCTCACCACCGTCGACGCCGGCACCAGGGCCGCGCGCTTCATGATCTCCGATGCGCTGGGCAACTTTGGCGGTGTGCTGCGCAAACTGCAGAATCCGAGCTGGCGTCCCGGTGCGTGGGCTTGCCGTTTGGTGGTCGTCGCGGCGTGGGGCAGCATCCTGCTGCTCGGTGTGACCGATCCGCTGGGCGGCATCAACACGCTGTTCCCGCTGTTCGGCATTGCCAACCAGTTGCTTGCCGGAATTGCGCTGACCGTCATCACCGTCGTCGTCATCAAGAAGGGGCGACTGAAGTGGGCTTGGATACCGGGTATTCCACTGCTGTGGGATCTGGCGGTCACCCTGACCGCATCGTGGCAGAAGATCTTCTCCGCTGATCCTTCTGTCGGCTACTGGACTCAGCATGCTCACTACGCGGCAGCCCAGCACGCAGGCGAGACCGCGTTCGGCTCGGCCACCAACGCCGATGAGATCAACGACGTCGTCCGGAACACATTCGTCCAGGGCACCCTGTCGATCGTCTTCGTGGTGGTCGTCGTGCTGGTTGTTGTCGCCGGAGTCATAGTGGCGCTGAAGACAATTCGCGGCCGCGGCATACCGTTGGCCGAGGACGATCCGGCGCCGTCGACGTTGTTCGCGCCCGCTGGCCTGATTCCTACAGCCGCAGAGCGAAAGTTGCAACGACGTTTGGGCGCGCCGGCCTCGGCTTCCGTCGCGGCGCCCGACTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Involved in peptide utilization. {ECO:0000250|UniProtKB:P15078}.

Family

Peptide transporter carbon starvation (CstA) (TC 2.A.114) family

GO

cellular response to starvation GO:0009267 biological_process
protein transport GO:0015031 biological_process
integral component of plasma membrane GO:0005887 cellular_component
cellular response to nutrient levels GO:0031669 biological_process

InterPro

UniProt: P9WP47
GenBank: Rv3063
EnsemblBacteria: Rv3063
Mycobrowser: Rv3063

Summary

Name: Peptide transporter CstA (Carbon starvation protein A homolog)
Family: Peptide transporter carbon starvation (CstA) (TC 2.A.114) family
Protein Sequence: MAAPTPSNRIEERSGHASCVRADADLPPVAILGRSPITLRHKIFFVAVAVIGALAWTVVAFFRNEPVNAVWIVVAAGCTYIIGFRFYARLIEMKVVRPRDDHATPAEILDDGTDYVPTDRRVVFGHHFAAIAGAGPLVGPVLATQMGYLPSSIWIVVGAVLAGCVQDYLVLWISVRRRGRSLGQMVRDELGATAGVAALVGIPVIITIVIAVLALVVVRALAKSPWGVFSIAMTIPIAIFMGCYLRFLRPGRVSEVSLIGIGLLLLAVVSGDWVAHTSWGAAWFSLSPVTLCWLLISYGFAASVLPVWLLLAPRDYLSTFMKVGTIALLAIGVCAAHPIIEAPAVSKFAGSGNGPVFAGSLFPFLFITIACGALSGFHALICSGTTPKMLEKEGQMRVIGYGGMMTESFVAVIALLTAAILDQHLYFTLNAPSLHTHDSAATAAKYVNGLGLTGSPVTPDHISQAAASVGEQTIVSRTGGAPTLAFGMAEMLHRVVGGVGLKAFWYHFAIMFEALFILTTVDAGTRAARFMISDALGNFGGVLRKLQNPSWRPGAWACRLVVVAAWGSILLLGVTDPLGGINTLFPLFGIANQLLAGIALTVITVVVIKKGRLKWAWIPGIPLLWDLAVTLTASWQKIFSADPSVGYWTQHAHYAAAQHAGETAFGSATNADEINDVVRNTFVQGTLSIVFVVVVVLVVVAGVIVALKTIRGRGIPLAEDDPAPSTLFAPAGLIPTAAERKLQRRLGAPASASVAAPD
Mass: 80,163 Da
Length: 758 Aa

Rv3063 doesn't seem to be a targeted by any drug.

Rv3063 doesn't seem to be involved in any pathway.

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.