Gene - combatTB X

Type: protein_coding
Name: virS
Locus Name: Rv3082c
Product: Virulence-regulating transcriptional regulator VirS (AraC/XylS family)
Functional Category: Virulence, detoxification, adaptation
Location: 3447404..3448426 (- strand)
Gene Length: 1022 bp
Nucleotides: ATGGAGCTGGGCAGCCTCATCCGCGCCACCAACCTGTGGGGGTACACCGACCTGATGCGCGAGCTCGGCGCGGACCCGCTGCCGTTTCTGCGGCGCTTCGACATCCCGCCGGGCATCGAACACCAAGAGGACGCGTTCATGTCGCTGGCCGGGTTCGTGCGCATGCTGGAGGCCAGCGCCGCCGAGCTCGATTGCCCGGACTTCGGACTACGCCTTGCACGCTGGCAGGGCCTGGGCATTCTCGGCCCGGTAGCGGTGATCGCGCGCAACGCTGCCACCTTGTTCGGCGGGCTGGAGGCGATCGGTCGCTACCTCTACGTCCATTCGCCCGCCCTGACGCTGACGGTTTCATCAACTACCGCACGGTCCAACGTCCGGTTCGGCTATGAGGTGACCGAACCGGGGATTCCCTATCCGCTGCAGGGATACGAGCTGAGCATGGCCAACGCCGCCCGGATGATCCGCCTGCTGGGCGGACCGCAGGCGCGGGCGCGCGTTTTCTCGTTCCGACATGCGCAACTGGGCACCGACGCCGCCTACCGCGAAGCGTTGGGTTGTACCGTTCGGTTCGGCCGGACATGGTGCGGGTTCGAGGTGGACCACCGGCTCGCCGGTAGGCCCATCGACCATGCGGATCCGGAAACCAAGCGCATCGCCACGAAATATTTGGAATCCCAATACCTTCCGAGCGATGCCACGCTCTCCGAGCGGGTCGTCGGGTTGGCCCGCCGCCTGCTGCCGACCGGCCAATGCAGCGCCGAGGCCATCGCCGACCAACTCGACATGCACCCACGAACGCTGCAGCGGCGCTTGGCTGCCGAGGGCCTCCGGTGCCATGACCTCATCGAGCGCGAACGCCGTGCGCAAGCGGCAAGGTACCTCGCCCAACCGGGGTTGTATCTGAGCCAAATCGCGGTGCTGCTCGGCTATTCCGAGCAGAGCGCGCTCAACCGGTCGTGCCGGCGCTGGTTTGGGATGACACCCCGGCAGTATCGAGCCTATGGTGGGGTCAGCGGTCGGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Regulates the expression of the mymA operon (Rv3083-Rv3089). {ECO:0000269|PubMed:14568148}.

Family

Unknown

GO

cellular response to acidic pH GO:0071468 biological_process
pathogenesis GO:0009405 biological_process
DNA-binding transcription factor activity GO:0003700 molecular_function
cytosol GO:0005829 cellular_component
positive regulation of transcription, DNA-templated GO:0045893 biological_process
sequence-specific DNA binding GO:0043565 molecular_function

InterPro

Summary

Name: HTH-type transcriptional regulator VirS (Virulence-regulating protein VirS)
Family: Unknown
Protein Sequence: MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQEDAFMSLAGFVRMLEASAAELDCPDFGLRLARWQGLGILGPVAVIARNAATLFGGLEAIGRYLYVHSPALTLTVSSTTARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGPQARARVFSFRHAQLGTDAAYREALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRIATKYLESQYLPSDATLSERVVGLARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGLRCHDLIERERRAQAARYLAQPGLYLSQIAVLLGYSEQSALNRSCRRWFGMTPRQYRAYGGVSGR
Mass: 37,789 Da
Length: 340 Aa

Rv3082c doesn't seem to be a targeted by any drug.

Rv3082c doesn't seem to be involved in any pathway.

The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS.: J Biol Chem. 2009 Apr 24;284(17):11090-9. doi: 10.1074/jbc.M808705200. Epub 2009 Feb 27.
Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs.: J Bacteriol. 2005 Jun;187(12):4173-86. doi: 10.1128/JB.187.12.4173-4186.2005.
mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope.: FEMS Microbiol Lett. 2003 Oct 10;227(1):53-63. doi: 10.1016/S0378-1097(03)00648-7.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
Sequence of a newly identified Mycobacterium tuberculosis gene encoding a protein with sequence homology to virulence-regulating proteins.: Gene. 1993 Apr 15;126(1):157-8.