Rv3087
- Type
- protein_coding
- Name
- Rv3087
- Locus Name
-
Rv3087
- Product
-
Possible triacylglycerol synthase (diacylglycerol acyltransferase)
- Functional Category
-
Lipid metabolism
- Location
- 3452925..3454343 (+ strand)
- Gene Length
- 1418 bp
- Nucleotides
-
TGCGCAGGCTCAACGGCGTTGACGCGCTGATGCTGTATCTCGACGGCGGCAGCGCCTACAACCACACCCTCAAGATCAGCGTGCTCGACCCGTCGACCGACCCGGACGGCTGGTCGTGGCCGAAGGCGCGGCAGATGTTCGAGGAGCGCGCCCACCTGCTTCCGGTCTTCCGGCTGCGGTACCTGCCCACACCGCTGGGCCTGCATCACCCGATCTGGGTCGAGGATCCCGAATTCGACCTCGACGCGCACGTGCGCCGGGTCGTCTGTCCCGCCCCGGGCGGGATGGCGGAATTCTGCGCGCTCGTCGAGCAGATCTACGCCCACCCGCTGGATCGCGACCGCCCGCTGTGGCAGACCTGGGTGGTCGAGGGCCTCGACGGCGGCCGCGTCGCCCTGGTCACGCTGCTGCACCACGCCTACTCCGACGGCGTCGGCGTGCTGGACATGCTCGCCGCGTTCTACAACGACACGCCTGACGAGGCCCCCGTGGTTGCGCCCCCGTGGGAGCCGCCGCCGCTGCCGTCCACCCGGCAACGCCTCGGTTGGGCCCTGCGGGACCTGCCCTCCAGGCTCGGCAAGATCGCGCCGACCGTGCGGGCCGTTCGTGATCGGGTGCGCATCGAACGGGAGTTCGCCAAAGACGGCGACCGGCGCGTCCCGCCCACGTTCGACCGCTCCGCACCGCCGGGCCCGTTTCAGCGCGGGCTGTCGCGCAGCCGGCGGTTCTCCTGCGAATCGTTCCCGCTCGCCGAGGTTCGCGAGGTGAGCAAGACGCTGGGCGTCACCATCAACGACGTCTTTTTGGCGTGTGTGGCCGGTGCCGTTCGTCGCTATCTGGAGCGTTGCGGCTCCCCTCCCACCGACGCGATGGTGGCCACGATGCCGCTCGCGGTCACCCCGGCGGCCGAGCGCGCCCACCCCGGCAACTACTCGTCGGTCGACTACGTCTGGCTACGCGCCGACATCGCCGACCCGCTCGAGCGGCTACACGCGACCCACCTCGCCGCCGAGGCCACCAAGCAGCACTTCGCCCAGACCAAGGACGCCGACGTCGGCGCGGTGGTCGAGCTGCTGCCGGAACGCCTCATCTCGGGCCTGGCGCGTGCCAACGCGCGCACCAAGGGCCGCTTCGACACCTTCAAGAACGTGGTCGTGTCCAACGTGCCGGGGCCGCGTGAGCCGCGGTATCTCGGCCGCTGGCGCGTCGACCAGTGGTTTTCCACCGGGCAGATCTCCCACGGCGCCACGCTCAACATGACCGTCTGGAGCTATTGCGACCAGTTCAACCTGTGCGTAATGGCCGACGCAGTCGCGGTTCGGAACACCTGGGAATTGCTCGGCGGCTTCCGCGCCTCGCACGAGGAGCTGCTCGCGGCGGCCCGTGCCCAAGCCACGCCCAAGGAGATGGCCACATGA
- Drug Resistance
- Mutations
- Function
- Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. {ECO:0000269|PubMed:15262939, ECO:0000269|PubMed:15937179}.
- Family
-
Long-chain O-acyltransferase family
- GO
-
- triglyceride biosynthetic process GO:0019432 biological_process
- response to acidic pH GO:0010447 biological_process
- response to nitric oxide GO:0071731 biological_process
- growth of symbiont in host cell GO:0044119 biological_process
- glycerol metabolic process GO:0006071 biological_process
- negative regulation by symbiont of host immune response GO:0052562 biological_process
- plasma membrane GO:0005886 cellular_component
- long-chain-alcohol O-fatty-acyltransferase activity GO:0047196 molecular_function
- response to hypoxia GO:0001666 biological_process
- diacylglycerol O-acyltransferase activity GO:0004144 molecular_function
- InterPro
Summary
- Name
- Putative diacyglycerol O-acyltransferase Rv3087 (EC 2.3.1.20) (Putative triacylglycerol synthase Rv3087)
- Family
- Long-chain O-acyltransferase family
- Protein Sequence
-
MRRLNGVDALMLYLDGGSAYNHTLKISVLDPSTDPDGWSWPKARQMFEERAHLLPVFRLRYLPTPLGLHHPIWVEDPEFDLDAHVRRVVCPAPGGMAEFCALVEQIYAHPLDRDRPLWQTWVVEGLDGGRVALVTLLHHAYSDGVGVLDMLAAFYNDTPDEAPVVAPPWEPPPLPSTRQRLGWALRDLPSRLGKIAPTVRAVRDRVRIEREFAKDGDRRVPPTFDRSAPPGPFQRGLSRSRRFSCESFPLAEVREVSKTLGVTINDVFLACVAGAVRRYLERCGSPPTDAMVATMPLAVTPAAERAHPGNYSSVDYVWLRADIADPLERLHATHLAAEATKQHFAQTKDADVGAVVELLPERLISGLARANARTKGRFDTFKNVVVSNVPGPREPRYLGRWRVDQWFSTGQISHGATLNMTVWSYCDQFNLCVMADAVAVRNTWELLGGFRASHEELLAAARAQATPKEMAT
- Mass
- 52,597 Da
- Length
- 472 Aa
Rv3087 doesn't seem to be a targeted by any drug.
-
-
Glycerolipid metabolism mtu00561
mtu00561PATHWAY_MAP mtu00561 Glycerolipid metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- The acid-induced operon Rv3083-Rv3089 is required for growth of Mycobacterium tuberculosis in macrophages.
- Tuberculosis (Edinb). 2007 Jan;87(1):12-20. doi: 10.1016/j.tube.2006.01.021. Epub 2006 Aug 8.
- Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs.
- J Bacteriol. 2005 Jun;187(12):4173-86. doi: 10.1128/JB.187.12.4173-4186.2005.
- Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture.
- J Bacteriol. 2004 Aug;186(15):5017-30. doi: 10.1128/JB.186.15.5017-5030.2004.
- mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope.
- FEMS Microbiol Lett. 2003 Oct 10;227(1):53-63. doi: 10.1016/S0378-1097(03)00648-7.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.