moaA1
- Type
- protein_coding
- Name
- moaA1
- Locus Name
-
Rv3109
- Product
-
Probable molybdenum cofactor biosynthesis protein A MoaA1
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3477649..3478728 (+ strand)
- Gene Length
- 1079 bp
- Nucleotides
-
TGAGTACGCCTACGCTGCCTGATATGGTAGCTCCATCCCCGAGAGTGCGAGTAAAAGACCGTTGTCGCCGGATGATGGGGGACCTACGCCTTTCCGTTATCGATCAGTGCAATTTGCGATGCCGTTATTGTATGCCCGAAGAGCACTACACATGGTTGCCGCGGCAAGATTTGCTATCCGTCAAAGAAATCAGCGCCATTGTAGATGTTTTCCTTTCCGTTGGGGTAAGTAAAGTTCGAATCACCGGTGGCGAACCGCTGATCCGCCCAGATTTGCCGGAAATAGTGAGGACATTGAGCGCAAAGGTCGGCGAAGATTCAGGTCTGAGAGACTTAGCGATCACGACGAACGGCGTCCTTCTCGCCGACCGCGTTGACGGCCTGAAGGCTGCGGGTATGAAACGCATCACTGTCAGTCTTGATACGTTGCAACCCGAGCGCTTCAAGGCGATAAGTCAGCGTAATAGCCACGATAAGGTCATCGCGGGTATCAAGGCTGTCGCAGCCGCGGGATTTACGGACACAAAAATAGACACAACGGTGATGCGTGGTGCCAATCACGATGAGCTGGCTGATCTGATCGAATTCGCTCGGACTGTTAACGCGGAAGTCAGGTTCATTGAGTACATGGACGTCGGCGGCGCAACTCACTGGGCATGGGAGAAGGTCTTTACCAAAGCGAACATGCTCGAGTCCCTTGAGAAACGGTATGGACGTATTGAGCCTTTGCCCAAACATGATACGGCGCCCGCCAATCGATATGCGCTTCCGGACGGAACTACCTTCGGAATTATCGCGTCGACAACGGAGCCATTCTGCGCAACCTGTGACCGTTCACGGTTGACCGCCGATGGCTTATGGCTGCATTGCTTGTACGCAATATCGGGTATCAACCTAAGGGAGCCGCTGCGTGCAGGCGCGACTCACGATGACTTGGTGGAAACCGTGACAACCGGATGGCGGCGACGAACGGATCGCGGAGCAGAGCAGCGTCTTGCCCAACGCGAGCGCGGAGTGTTCCTGCCATTAAGCACGTTAAAGGCCGACCCGCATCTGGAGATGCACACCAGGGGCGGGTAA
- Drug Resistance
- Mutations
- Function
- Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. {ECO:0000255|HAMAP-Rule:MF_01225}.
- Family
-
Radical SAM superfamily, MoaA family
- GO
-
- metal ion binding GO:0046872 molecular_function
- molybdopterin synthase complex GO:0019008 cellular_component
- GTP 3',8'-cyclase activity GO:0061798 molecular_function
- S-adenosyl-L-methionine binding GO:1904047 molecular_function
- GTP binding GO:0005525 molecular_function
- Mo-molybdopterin cofactor biosynthetic process GO:0006777 biological_process
- 4 iron, 4 sulfur cluster binding GO:0051539 molecular_function
- plasma membrane GO:0005886 cellular_component
- InterPro
Summary
- Name
- GTP 3',8-cyclase 1 (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A 1)
- Family
- Radical SAM superfamily, MoaA family
- Protein Sequence
-
MSTPTLPDMVAPSPRVRVKDRCRRMMGDLRLSVIDQCNLRCRYCMPEEHYTWLPRQDLLSVKEISAIVDVFLSVGVSKVRITGGEPLIRPDLPEIVRTLSAKVGEDSGLRDLAITTNGVLLADRVDGLKAAGMKRITVSLDTLQPERFKAISQRNSHDKVIAGIKAVAAAGFTDTKIDTTVMRGANHDELADLIEFARTVNAEVRFIEYMDVGGATHWAWEKVFTKANMLESLEKRYGRIEPLPKHDTAPANRYALPDGTTFGIIASTTEPFCATCDRSRLTADGLWLHCLYAISGINLREPLRAGATHDDLVETVTTGWRRRTDRGAEQRLAQRERGVFLPLSTLKADPHLEMHTRGG
- Mass
- 39,960 Da
- Length
- 359 Aa
Rv3109 doesn't seem to be a targeted by any drug.
-
-
Folate biosynthesis mtu00790
mtu00790PATHWAY_MAP mtu00790 Folate biosynthesis
-
- Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue.
- Microbiology. 2010 Jul;156(Pt 7):2112-23. doi: 10.1099/mic.0.037200-0. Epub 2010 Apr 8.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.