moaC1
- Type
- protein_coding
- Name
- moaC1
- Locus Name
-
Rv3111
- Product
-
Probable molybdenum cofactor biosynthesis protein C MoaC1
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3479171..3479683 (+ strand)
- Gene Length
- 512 bp
- Nucleotides
-
TGATCGACCATGCACTCGCGCTGACACATATCGATGAGCGTGGTGCGGCACGAATGGTCGATGTGTCCGAGAAACCCGTGACTTTGAGGGTTGCCAAAGCGTCAGGGCTCGTGATCATGAAGCCGTCTACCTTGAGGATGATTTCCGACGGTGCCGCTGCTAAGGGTGACGTCATGGCGGCGGCCCGGATAGCTGGCATCGCGGCGGCGAAACGTACGGGTGATCTTATTCCGCTATGCCACCCGTTAGGGCTCGACGCTGTCAGCGTCACTATCACGCCGTGCGAGCCTGACCGGGTGAAGATTCTGGCGACAACCACCACGCTGGGGCGTACCGGCGTGGAAATGGAAGCGTTGACCGCAGTTTCAGTCGCCGCCTTGACTATCTACGACATGTGCAAAGCCGTCGATCGAGCCATGGAGATTTCTCAGATCGTGCTCCAAGAGAAAAGCGGCGGCCGGTCCGGAGTTTATCGCCGAAGTGCTTCTGATTTGGCCTGTCAGTCCCGATAA
- Drug Resistance
- Mutations
- Function
- Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) (By similarity). Probably plays a role in host phagosome maturation arrest (PubMed:20844580). {ECO:0000255|HAMAP-Rule:MF_01224, ECO:0000305|PubMed:20844580}.
- Family
-
MoaC family
- GO
-
- cyclic pyranopterin monophosphate synthase activity GO:0061799 molecular_function
- extracellular region GO:0005576 cellular_component
- negative regulation by symbiont of host innate immune response GO:0052170 biological_process
- Mo-molybdopterin cofactor biosynthetic process GO:0006777 biological_process
- InterPro
Summary
- Name
- Cyclic pyranopterin monophosphate synthase 1 (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C 1)
- Family
- MoaC family
- Protein Sequence
-
MIDHALALTHIDERGAARMVDVSEKPVTLRVAKASGLVIMKPSTLRMISDGAAAKGDVMAAARIAGIAAAKRTGDLIPLCHPLGLDAVSVTITPCEPDRVKILATTTTLGRTGVEMEALTAVSVAALTIYDMCKAVDRAMEISQIVLQEKSGGRSGVYRRSASDLACQSR
- Mass
- 17,845 Da
- Length
- 170 Aa
Rv3111 doesn't seem to be a targeted by any drug.
-
-
Folate biosynthesis mtu00790
mtu00790PATHWAY_MAP mtu00790 Folate biosynthesis
-
- High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling.
- PLoS Pathog. 2010 Sep 9;6(9):e1001100. doi: 10.1371/journal.ppat.1001100.
- Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue.
- Microbiology. 2010 Jul;156(Pt 7):2112-23. doi: 10.1099/mic.0.037200-0. Epub 2010 Apr 8.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.