Function

Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response (PubMed:12953092). Regulates an approximately 48-member regulon (PubMed:12953092, PubMed:11416222, PubMed:15033981, PubMed:18400743). Required for full induction of the DevR (DosR) regulon; acts later than DosT to positively regulate expression of the DevR regulon during adaptation to anaerobiosis (PubMed:19487478). Characterized as an oxygen sensor; O(2) acts as a switch, with O(2)-bound Fe(2+) protein inactive in autophosphorylation (PubMed:17371046, PubMed:17600145, PubMed:18975917, PubMed:19463006, PubMed:28977726). Has also been suggested to act as a redox sensor, or perhaps as a dual oxygen/redox sensor (PubMed:17609369). Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO does not dramatically change the level of autophosphorylation of Fe(2+) protein, binding of O(2) inactivates kinase activity (PubMed:17600145, PubMed:18975917, PubMed:27235395). Binds O(2), NO, CO (PubMed:17371046, PubMed:17609369, PubMed:17600145, PubMed:18975917, PubMed:27235395). It is probably reduced by flavin nucleotides such as FMN and FAD (PubMed:19276084). May be the primary sensor for CO (PubMed:18400743). Donates a phosphate group to transcriptional regulator DevR (DosR) (PubMed:15033981, PubMed:15073296, PubMed:28977726). {ECO:0000269|PubMed:11416222, ECO:0000269|PubMed:12953092, ECO:0000269|PubMed:15033981, ECO:0000269|PubMed:15073296, ECO:0000269|PubMed:17371046, ECO:0000269|PubMed:17600145, ECO:0000269|PubMed:17609369, ECO:0000269|PubMed:18400743, ECO:0000269|PubMed:18474359, ECO:0000269|PubMed:18975917, ECO:0000269|PubMed:19463006, ECO:0000269|PubMed:19487478, ECO:0000269|PubMed:27235395, ECO:0000269|PubMed:28977726}.

Family

Unknown

GO

• protein dimerization activity GO:0046983 molecular_function
• protein autophosphorylation GO:0046777 biological_process
• heme binding GO:0020037 molecular_function
• magnesium ion binding GO:0000287 molecular_function
• oxygen sensor activity GO:0019826 molecular_function
• oxygen binding GO:0019825 molecular_function
• cell wall GO:0005618 cellular_component
• ATP binding GO:0005524 molecular_function
• detection of hypoxia GO:0070483 biological_process
• plasma membrane GO:0005886 cellular_component
• cytoplasm GO:0005737 cellular_component
• nitric oxide binding GO:0070026 molecular_function
• carbon monoxide binding GO:0070025 molecular_function
• phosphorelay sensor kinase activity GO:0000155 molecular_function
• detection of redox state GO:0051776 biological_process
• response to redox state GO:0051775 biological_process
• integral component of membrane GO:0016021 cellular_component
• protein kinase activity GO:0004672 molecular_function

InterPro

• IPR003018
• IPR029016
• IPR003594
• IPR036890
• IPR005467
• IPR011712

UniProt

P9WGK3

GenBank

Rv3132c

EnsemblBacteria

Rv3132c

Mycobrowser

Rv3132c

Rv3132c doesn't seem to be a targeted by any drug.

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  Two-component system mtu02020

  mtu02020

  Environmental Information Processing; Signal transduction