Gene - combatTB X

pflA

Type: protein_coding
Name: pflA
Locus Name: Rv3138
Product: Probable pyruvate formate lyase activating protein PflA (formate acetyltransferase activating enzyme) ([pyruvate formate-lyase] activating enzyme)
Functional Category: Intermediary metabolism and respiration
Location: 3504195..3505283 (+ strand)
Gene Length: 1088 bp
Nucleotides: TGAGCGACCCGTTCACCATCGCAACCAAACACTGGCACCGACTGCACGACAGCCGGATCCAGTGCGATGTATGTCCACGCGCATGCAAACTTCACGAGGGACAGCGTGGCCTGTGTTTCGTCCGCGGCCGATTTGACGATCAAGTGAAGCTCACCAGCTACGGACGCTCTAGCGGATTCTGTGTCGATCCGATCGAGAAAAAGCCGCTCAACCACTTCTTGCCAGGTTCGGCGACGCTGTCTTTCGGCACCGCCGGGTGCAACCTGGCGTGCAAGTTCTGCCAGAACTGGGATATCTCCAAGTCCCGCGAGATCGACGTCCTGGCCAGTCGGGCGGCCCCGGCCGACATCGCCCGGACCGCACACGAATTGGGTTGCCGCAGCGTGGCATTCACCTACAACGACCCAACGATCTTCTGGGAGTATGCCGCCGATGTAGCCGACGCCTGCCACGACCAGGGAATCAAAGCCGTCGCGGTGACGGCCGGGTACATGTGTCCTGAGCCCCGCGCGGAATTCTACCGGCGTGTCGACGCCGCCAACGTCGACCTAAAGGCATTCACCGAAGACTTTTATCGCAAGGTTTGCGTCAGTCACCTGCGCAACGTCCTGGACACCCTGGCCTACCTGCGGCACCAGACGAATGTGTGGTTGGAGATCACCACCCTGCTGATTCCCGGACGTAACGACAGCGACGCGGAAGTCGCTGCCGAATGCAGATGGATCCGCGAAAACCTGGGCGTCGACGTGCCGGTGCATTTCACCGCGTTCCATCCCGACTACAAGATGATGGACACCCCGGCTACACCAACCGCCACATTGACCCGAGCCCGCGAGATCGGCATTGGCGAAGGCCTGCGCTTCGTCTACACCGGAAACGTTCACGATGCCGTGGGTGGCAGCACCTCGTGCCCAGGCTGCCGGGCAACGGTGATCGTTCGCGACTGGTATTCGATACGACATTACGCCCTCACCGAGGACGGCCGCTGCCAAGCATGCGGCTATCAGATGCCTGGCGTGTACGACGGACCGGCCGGACACTGGGGCCAGCGCCGGCTGCCCTTGCTGACCAGCTTGTCCCGGATGTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

metal ion binding GO:0046872 molecular_function
iron-sulfur cluster binding GO:0051536 molecular_function
lyase activity GO:0016829 molecular_function
transferase activity GO:0016740 molecular_function

InterPro

UniProt: P95188
GenBank: Rv3138
EnsemblBacteria: Rv3138
Mycobrowser: Rv3138

Summary

Name: Probable pyruvate formate lyase activating protein PflA (Formate acetyltransferase activating enzyme) ([pyruvate formate-lyase] activating enzyme)
Family: Unknown
Protein Sequence: MSDPFTIATKHWHRLHDSRIQCDVCPRACKLHEGQRGLCFVRGRFDDQVKLTSYGRSSGFCVDPIEKKPLNHFLPGSATLSFGTAGCNLACKFCQNWDISKSREIDVLASRAAPADIARTAHELGCRSVAFTYNDPTIFWEYAADVADACHDQGIKAVAVTAGYMCPEPRAEFYRRVDAANVDLKAFTEDFYRKVCVSHLRNVLDTLAYLRHQTNVWLEITTLLIPGRNDSDAEVAAECRWIRENLGVDVPVHFTAFHPDYKMMDTPATPTATLTRAREIGIGEGLRFVYTGNVHDAVGGSTSCPGCRATVIVRDWYSIRHYALTEDGRCQACGYQMPGVYDGPAGHWGQRRLPLLTSLSRM
Mass: 40,433 Da
Length: 362 Aa

Rv3138 doesn't seem to be a targeted by any drug.

Rv3138 doesn't seem to be involved in any pathway.

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.