nuoH
- Type
- protein_coding
- Name
- nuoH
- Locus Name
-
Rv3152
- Product
-
Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3519282..3520514 (+ strand)
- Gene Length
- 1232 bp
- Nucleotides
-
TGACCACGTTCGGCCACGACACCTGGTGGCTGGTGGCGGCCAAAGCGATCGCGGTATTCGTGTTCCTCATGCTGACGGTGCTGGTGGCGATCCTGGCCGAACGCAAGCTGCTGGGCCGGATGCAGTTGCGGCCCGGCCCCAACCGGGTTGGCCCAAAAGGAGCCCTGCAGAGCCTGGCTGACGGCATCAAGCTGGCGCTCAAAGAGAGCATCACACCCGGTGGCATCGATCGATTCGTATATTTTGTGGCGCCGATCATTTCGGTGATTCCGGCATTCACCGCTTTCGCGTTCATCCCGTTTGGTCCCGAGGTGTCGGTGTTTGGCCACCGGACACCGTTGCAGATAACCGACCTTCCCGTCGCCGTGCTGTTCATCCTGGGACTGTCGGCGATCGGGGTATACGGCATCGTGCTGGGCGGTTGGGCGTCCGGGTCCACCTACCCGCTGCTGGGCGGGGTGCGCTCCACCGCGCAGGTCATCTCCTACGAGGTCGCGATGGGCCTGTCGTTCGCGACGGTGTTCCTTATGGCCGGCACCATGTCGACGTCGCAGATCGTGGCCGCACAAGACGGTGTCTGGTATGCCTTCCTGTTGTTGCCGTCATTCGTCATCTATCTCATTTCTATGGTGGGTGAAACCAACCGGGCGCCGTTCGATTTGCCCGAAGCCGAGGGCGAGCTGGTCGCGGGATTCCACACCGAGTACTCGTCGTTGAAGTTCGCGATGTTCATGCTCGCCGAGTACGTCAATATGACTACGGTTTCGGCACTGGCCGCGACCCTATTCTTCGGTGGCTGGCATGCTCCCTGGCCGCTGAACATGTGGGCGAGCGCCAACACCGGCTGGTGGCCACTGATCTGGTTCACCGCTAAAGTGTGGGGCTTTCTGTTCATCTATTTCTGGCTGCGGGCTACGCTGCCGCGGCTGCGCTACGACCAGTTCATGGCGCTGGGCTGGAAGTTATTGATCCCCGTCTCGCTGGTGTGGGTGATGGTCGCCGCGATCATCCGCTCACTACGCAACCAGGGCTACCAGTACTGGACCCCGACTCTGGTGTTTAGCAGCATTGTCGTTGCCGCTGCCATGGTGCTGTTGTTGCGAAAGCCGTTGAGCGCTCCCGGCGCTCGCGCATCGGCACGGCAACGCGGGGACGAAGGCACCAGCCCTGAACCGGCATTTCCGACACCACCGCTGCTAGCCGGTGCAACCAAGGAGAATGCAGGTGGCTAA
- Drug Resistance
- Mutations
- Function
- NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. {ECO:0000255|HAMAP-Rule:MF_01350}.
- Family
-
Complex I subunit 1 family
- GO
-
- aerobic respiration GO:0009060 biological_process
- plasma membrane GO:0005886 cellular_component
- quinone binding GO:0048038 molecular_function
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0016655 molecular_function
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- NADH-quinone oxidoreductase subunit H (EC 7.1.1.-) (NADH dehydrogenase I subunit H) (NDH-1 subunit H)
- Family
- Complex I subunit 1 family
- Protein Sequence
-
MTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLADGIKLALKESITPGGIDRFVYFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISYEVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLKFAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMALGWKLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPLLAGATKENAGG
- Mass
- 44,658 Da
- Length
- 410 Aa
Rv3152 doesn't seem to be a targeted by any drug.
-
-
Oxidative phosphorylation mtu00190
mtu00190PATHWAY_MAP mtu00190 Oxidative phosphorylation
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.