moeB1
- Type
- protein_coding
- Name
- moeB1
- Locus Name
-
Rv3206c
- Product
-
Probable molybdenum cofactor biosynthesis protein MoeB1 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 3582532..3583710 (- strand)
- Gene Length
- 1178 bp
- Nucleotides
-
GTGTCGACATCCTTGCCGCCACTAGTTGAGCCAGCATCCGCGCTCAGCCGTGAAGAGGTAGCTCGCTACAGCCGCCATCTCATCATTCCTGACCTGGGTGTTGACGGGCAGAAGAGGCTCAAGAACGCGCGAGTACTGGTGATCGGCGCCGGCGGGCTCGGAGCGCCCACGTTATTGTATCTGGCCGCCGCCGGCGTCGGCACCATCGGCATCGTCGACTTCGATGTGGTTGACGAGTCGAACCTGCAGCGCCAGGTCATCCATGGGGTAGCTGACGTCGGGCGCTCCAAGGCTCAGTCGGCGCGCGATTCGATTGTCGCGATCAACCCGCTGATCCGGGTGCGACTACACGAGCTGCGGCTTGCGCCGAGCAACGCCGTCGACCTGTTCAAGCAGTACGACCTGATCTTGGATGGCACCGACAACTTCGCCACCCGGTATCTGGTCAACGACGCCGCGGTGCTGGCTGGCAAGCCGTACGTGTGGGGGTCGATTTACCGCTTCGAGGGCCAGGCATCGGTGTTTTGGGAGGACGCCCCCGACGGGTTGGGTGTCAACTACCGCGACCTGTATCCCGAGCCGCCGCCGCCGGGCATGGTGCCGTCCTGTGCTGAAGGCGGGGTGCTGGGCATTATCTGTGCCTCGGTCGCATCGGTGATGGGCACTGAGGCGATCAAGCTGATCACCGGGATAGGTGAAACACTGCTTGGCCGGTTGCTGGTGTACGACGCGCTGGAGATGAGCTATCGCACGATCACCATCCGCAAGGACCCATCGACACCGAAGATCACCGAGCTGGTCGACTACGAACAGTTCTGCGGCGTGGTTGCTGACGATGCCGCCCAGGCGGCCAAAGGTTCCACCATCACGCCGCGCGAGCTGCGCGACTGGCTGGACTCCGGCCGTAAGCTGGCACTGATCGACGTTCGCGATCCCGTGGAGTGGGACATCGTGCATATCGACGGAGCCCAACTGATTCCGAAATCGTTGATCAACTCGGGTGAGGGTCTGGCCAAGCTCCCCCAGGACCGCACCGCCGTGCTGTACTGCAAGACGGGCGTGCGCTCGGCCGAGGCATTGGCTGCGGTCAAGAAAGCCGGTTTCTCCGACGCGGTACACCTGCAGGGTGGGATCGTCGCGTGGGCCAAGCAGATGCAGCCCGACATGGTGATGTACTA
- Drug Resistance
- Mutations
- Function
- Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps: first, ATP-dependent activation of CysO as acyl-adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO-thiocarboxylate (CysO-COSH) (Probable). The sulfur source is unknown. {ECO:0000269|PubMed:16104727, ECO:0000305}.
- Family
-
HesA/MoeB/ThiF family
- GO
-
- cysteine biosynthetic process GO:0019344 biological_process
- ubiquitin-like modifier activating enzyme activity GO:0008641 molecular_function
- cell wall GO:0005618 cellular_component
- ATP binding GO:0005524 molecular_function
- cytosol GO:0005829 cellular_component
- active evasion of host immune response GO:0042783 biological_process
- cytoplasm GO:0005737 cellular_component
- sulfotransferase activity GO:0008146 molecular_function
- integral component of membrane GO:0016021 cellular_component
- nucleotidyltransferase activity GO:0016779 molecular_function
- transferase activity, transferring sulfur-containing groups GO:0016782 molecular_function
- cysteine biosynthetic process from serine GO:0006535 biological_process
- InterPro
Summary
- Name
- Probable adenylyltransferase/sulfurtransferase MoeZ [Includes: Sulfur carrier protein CysO adenylyltransferase (EC 2.7.7.-); Sulfur carrier protein CysO sulfurtransferase (EC 2.8.1.-)]
- Family
- HesA/MoeB/ThiF family
- Protein Sequence
-
MSTSLPPLVEPASALSREEVARYSRHLIIPDLGVDGQKRLKNARVLVIGAGGLGAPTLLYLAAAGVGTIGIVDFDVVDESNLQRQVIHGVADVGRSKAQSARDSIVAINPLIRVRLHELRLAPSNAVDLFKQYDLILDGTDNFATRYLVNDAAVLAGKPYVWGSIYRFEGQASVFWEDAPDGLGVNYRDLYPEPPPPGMVPSCAEGGVLGIICASVASVMGTEAIKLITGIGETLLGRLLVYDALEMSYRTITIRKDPSTPKITELVDYEQFCGVVADDAAQAAKGSTITPRELRDWLDSGRKLALIDVRDPVEWDIVHIDGAQLIPKSLINSGEGLAKLPQDRTAVLYCKTGVRSAEALAAVKKAGFSDAVHLQGGIVAWAKQMQPDMVMY
- Mass
- 42,173 Da
- Length
- 392 Aa
Rv3206c doesn't seem to be a targeted by any drug.
-
-
Cysteine synthesis from O-phosphoserine R-MTU-936654
Mycobacterium tuberculosisR-MTU-936654
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis.
- J Am Chem Soc. 2005 Aug 24;127(33):11602-3. doi: 10.1021/ja053476x.
- Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expression.
- Mol Microbiol. 2002 Jul;45(2):365-74.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.